In his analysis into myeloproliferative neoplasms, or MPNs, John Crispino is concentrated on a few key areas relating to understanding the underlying biology of the illness, as he defined in an interview with CURE.
Crispino is the director of the division of experimental hematology at St. Jude Kids’s Analysis Hospital in Memphis, Tennessee, the place he’s additionally the Wall Avenue Committee Endowed Chair and principal investigator of the Crispino Lab. The Crispino Lab, in line with its web site, is concentrated totally on myeloid cells, centered on the mechanisms of regular and irregular cell growth.
“There are two main areas that we research,” Crispino informed CURE. “The primary is the biology of megakaryocytes. These are the cells that make platelets. … The second main space of analysis is on leukemic development. So I’d say that that development to acute leukemia is de facto horrible consequence for sufferers, and we have now only a few therapies for sufferers that do advance at that stage. So our analysis prior to now few years has targeted on understanding the mechanism.”
Crispino sat down not too long ago with CURE to debate his analysis.
Transcript:
There are two main areas that we research. The primary is the biology of megakaryocytes. These are the cells that make platelets. And our analysis has proven that megakaryocytes are very irregular within the illness, and we have now predicted or hypothesized that these aberrant megakaryocytes instantly trigger most of the options of the illness, and that if we might provide you with methods to remove these irregular megakaryocytes, we might develop new therapies. The second main space of analysis is on leukemic development. So, I’d say that that development to acute leukemia is de facto horrible consequence for sufferers, and we have now only a few therapies for sufferers that do advance at that stage. So, our analysis prior to now few years has targeted on understanding the mechanism.
So, what are the genetic drivers of leukemia development after which utilizing that data to develop new therapies? … My ardour is to develop remedies to forestall and to deal with after which additionally forestall leukemic development. Once more, it is not a simple space of analysis, but it surely’s, I feel, to me, a very powerful space. There are numerous essential areas, in fact, within the MPNS, however I feel that that is an space very excessive unmet medical want.
Transcript has been edited for readability and conciseness.
For extra information on most cancers updates, analysis and training, don’t overlook to subscribe to CURE®’s newsletters right here.
