Blinded steady glucose monitoring (CGM) know-how worn throughout induction remedy might present dependable outcomes with out problems to pediatric sufferers with leukemia/lymphoma (ALL/LLy), in response to a research summary introduced on the American Diabetes Affiliation 84th Scientific Classes, held June 21 to 24 in Orlando, Florida.1
CGM on kid’s arm / habrovich – inventory.adobe.com
Throughout preliminary remedy in kids with ALL/LLy, hyperglycemia can result in elevated monitoring wants, further medical interventions, and longer hospital stays. Addressing this, investigators studied whether or not the usage of a CGM within the affected person inhabitants might cut back problems related to excessive blood sugar.
The research, carried out at Kids’s Healthcare of Atlanta, started in February 2022 and is ongoing. Kids with ALL/LLy between the ages of 1 and 21 are enrolled. Following participation in a mother or father research measuring hyperglycemia threat, members are invited to hitch a blinded CGM arm.
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Amongst 53 sufferers who accomplished preliminary remedy within the mother or father research as of December 2023, all skilled hyperglycemia. Most (77%) had grade 1 hyperglycemia, and the remainder (23%) had grade 2 or increased. Those that had grade 2 or hyper had been extra more likely to have a household historical past of diabetes, and insulin administration was required for sufferers who had grade 3 hyperglycemia.
9 sufferers used a CGM, carrying it for a median of 77% of the energetic monitoring interval. Six sufferers wore it for over 70% of the time. The CGM was utilized in almost half (44%) of sufferers within the CGM arm, in comparison with solely 2% within the non-CGM arm. No pores and skin rash or an infection occurred on the CGM website for any members.
Though the pilot research confirmed that CGM know-how might produce dependable outcomes with out problems, investigators famous that “further research are wanted to discover expanded use of CGM in related affected person populations.” That is particularly vital contemplating the rise in diabetes prevalence in younger folks. The CDC estimates that by 2060, 526,000 younger folks may have both sort 1 or sort 2 diabetes, in comparison with 213,000 diagnoses in 2017.2
CGM gives a number of benefits for sufferers with most cancers. Frequent therapies, similar to chemotherapy, administration of steroids, and synthetic vitamin could cause vast variability in blood sugar ranges.3 Uncontrolled, these fluctuations can worsen outcomes and lift an infection dangers. By offering real-time blood sugar information, CGM can enable for proactive changes in treatment or food regimen to take care of wholesome glucose ranges. What’s extra, CGMs can enable higher glucose administration for sufferers who’re asymptomatic.
CGMs get rid of the necessity for finger pricks, as effectively, which offers additional profit to sure affected person subpopulations. Whereas finger pricks could be extraordinarily painful for sufferers with chemotherapy-related neuropathy or trigger extended bleeding instances and bruising in sufferers with thrombocytopenia, CGMs require much less sticks.
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