Introduction
Childhood most cancers and its remedy could cause opposed bodily results (1–5), evident from as early as one week following analysis (6). Muscle loss, diminished health, fatigue, and motor impairment are prevalent amongst kids and adolescents present process acute most cancers remedy. These opposed results aren’t restricted to the acute remedy section. Adults who’ve undergone childhood most cancers remedy show excessive ranges of sedentary conduct, can expertise lifelong incapacity and impairment, and are at an elevated danger of persistent illness and untimely mortality (7–9). A rising variety of childhood most cancers survivors are reaching maturity, which will increase the burden of those opposed outcomes (10). Intervening early might work to mitigate these detrimental results and promote improved bodily operate and wellbeing within the instant and long-term.
Bodily exercise is significant to well being and improvement (11, 12), but, kids and adolescents present process acute most cancers remedy are much less lively than their age-matched friends (13, 14). Kids and adolescents can obtain intensive most cancers therapies over the course of many months (15). Over this time, opposed remedy results can compromise a baby’s potential to be bodily lively and functionally unbiased. For this inhabitants, bodily exercise has a job to play in managing treatment-related results, stopping (or minimizing) declines in bodily operate and psychological well being, sustaining bodily literacy abilities and selling lively existence (16, 17). Managing these detrimental elements by way of proactive bodily exercise promotion might assist to maximise their bodily operate and participation throughout most cancers remedy. This might in flip have a optimistic affect on long run well being outcomes, corresponding to lowering the danger of bodily impairment, metabolic syndrome and cardiovascular morbidity (18, 19). There may be rising proof to assist the advantages of bodily exercise for kids with most cancers (20–22), but the boundaries to bodily exercise on this setting are complicated, and there’s little consensus concerning find out how to implement possible, equitable and sustainable interventions (23, 24).
Bodily exercise encompasses any bodily motion leading to power expenditure (25). As a sub-section of bodily exercise, literature helps the advantages of supervised train (26–30). Supervised train interventions have robust attendance and adherence charges, and quite a few systematic opinions report its security and advantages (20, 24, 31–33). Nevertheless, supervised train usually goal impairments alone, and tie bodily exercise engagement to the presence of a skilled skilled. They’re additionally pricey. In remedy facilities with a excessive quantity of annual circumstances it may be difficult, from a funding perspective, to offer such providers to all households all through remedy. Selling bodily exercise in its broadest sense, from a conduct change perspective, might assist households to independently incorporate extra bodily exercise into their day by day routine (34–36). This has the potential to alleviate reliance on supervised train classes alone, permitting a extra nuanced and focused strategy to service supply; whereby, extra intensive assist is supplied to kids/adolescents if, and when, it’s wanted.
Complicated interventions comprise a number of interacting and versatile elements, have quite a few various outcomes and contain complicated behaviors (37). Bodily exercise is a posh conduct (38); for optimistic change, complicated interventions that contemplate particular person and environmental elements are required (38–40). Implementing methods that concentrate on bodily exercise conduct utilizing complicated intervention design methods are but to be totally explored within the acute pediatric most cancers setting. There are examples of complicated bodily exercise interventions throughout the acute most cancers remedy setting (41–44), but these examples both lack a transparent theoretical underpinning or fail to include methods that concentrate on the kid/adolescent and their social and bodily surroundings.
The UK’s Medical Analysis Council strategy to complicated intervention design requires a clear, and systematic course of that articulates the theoretical foundation for the intervention (45). Interventions are generally designed with out formal evaluation of the conduct to be focused, nor the theorized mechanism of motion. The theoretical underpinning of a posh intervention describes how the intervention is anticipated to work by way of outlining the anticipated causal pathways between the intervention elements, the anticipated outcomes and the way contextual elements would possibly affect these (46). Defining and endeavor a theoretical strategy to intervention design has many advantages. It helps researchers analyze the issue, perceive how an intervention can work, assess effectiveness and in the end improves replicability and scientific implementation of outcomes (47). Interventions designed through a theoretical course of are thought of to be more practical in resulting in lasting change (48).
The Conduct Change Wheel is a framework that integrates 19 present conduct change frameworks into one mannequin. The elements of the Conduct Change Wheel can be utilized to clarify bodily exercise conduct (49), and to information intervention design. This framework might be utilized throughout any sort of conduct and setting (50), and has been utilized in numerous well being contexts to design complicated bodily exercise interventions (51–54). The Conduct Change Wheel necessitates consideration of what inside situations particular to the person, and their social and bodily surroundings have to be in place for the goal conduct to be achieved (50). The COM-B element of the Conduct Change Wheel gives the strategy for understanding the conduct theoretically. Different theoretical frameworks corresponding to The Transtheoretical Mannequin of Conduct Change, Well being Selling Conduct, Idea of Deliberate Conduct, and Well being Perception Mannequin are generally cited within the context of complicated intervention design. These fashions might be useful to foretell, clarify or describe conduct, but have limitations for intervention design as they don’t require in-depth evaluation of the goal conduct, nor hyperlink theoretical constructs to mechanisms of change (50). The Conduct Change Wheel helps researchers design interventions by way of linking potential intervention elements with the goal conduct, inhabitants and surroundings during which they are going to be delivered (48).
The Conduct Change Wheel was used right here to design a posh intervention to advertise optimistic adjustments in bodily exercise conduct particularly for kids and adolescents receiving acute most cancers remedy. This paper outlines the theoretical course of undertaken. The choice-making course of that led to the resultant intervention “CanMOVE” will probably be described by way of the conduct change methods chosen and their mode of supply. CanMOVE will subsequently be piloted for feasibility.
Supplies and strategies
The Conduct Change Wheel was the theoretical framework used to tell the design of CanMOVE (50). This intervention aimed to focus on faculty aged kids (5–16 years) who have been present process acute most cancers remedy. The definition of acute most cancers remedy consists of hematopoietic stem cell transplantation and all remedy phases besides the ‘upkeep section’ of leukemia remedy. The analysis group members labored collaboratively by way of the three phases of this design course of outlined beneath (Determine 1).
Stage 1: Perceive the conduct (steps 1–4)
Steps 1–3 outline the issue and determine a particular conduct to vary. Steps 1–3 have been pre-determined previous to present process this design course of. As described within the introduction, CanMOVE goals to proactively attenuate the detrimental bodily well being and participation restrictions noticed for kids with most cancers. The goal conduct, bodily exercise, was decided primarily based on obtainable proof outlining that kids and adolescents present process most cancers remedy are much less bodily lively than age-matched friends, and the potential optimistic results of improved bodily engagement (7, 8, 13, 14).
Step 4 analyzed what wants to vary in an individual, and their surroundings to facilitate change within the goal conduct. The central elements of the Conduct Change Wheel, the COM-B mannequin, guided evaluation inside this step. The COM-B mannequin proposes that for somebody to undertake a specific conduct they have to be bodily and psychologically succesful, course of the need or must undertake the conduct (motivation), and have the social and bodily alternative to interact within the conduct (50). Every of those elements have been evaluated on their potential contribution to bodily exercise conduct particularly for kids and adolescents within the acute most cancers setting. Information from our qualitative research have been used to tell this evaluative course of (55). Information have been analyzed thematically, first through an inductive course of to determine emergent themes, and second through a deductive course of whereby the resultant themes have been mapped to every of the COM-B elements. Outcomes from further related qualitative literature that included insights from youngster and adolescent views have been additionally used (56–58). Based mostly on the recognized causes for diminished ranges of bodily exercise, an inventory of potential pathways to create change was generated.
Stage 2: Establish intervention choices (steps 5 and 6)
Stage 2 determines the varieties of intervention features and coverage classes that may very well be utilized to result in change within the goal conduct. Intervention features characterize the kind of intervention to be applied and coverage classes are selections made by authorities regarding these interventions (50). Elements recognized in stage 1 as contributing to bodily exercise conduct have been mapped to potential intervention features. This course of ensures intervention methods goal the precise inhabitants and their surroundings. For instance, abilities coaching could also be acceptable the place there’s a lack of ability however will probably be much less useful if an absence of motivation to carry out the ability is the underlying motive for the conduct (48). Figuring out potential coverage class methods was past the scope of this research.
Stage 3: Establish content material and implementation choices (steps 7 and eight)
Utilizing the intervention features recognized in stage 2, stage 3 concerned deciding on behavioral change methods that would kind the totally different elements of the intervention. Conduct change methods are the “lively components” chosen to comprise the intervention and facilitate a change in conduct. Clear identification and definition of the behavioral change methods chosen is essential to the evaluation of how an intervention works; it permits the researcher to precisely describe the intervention, and aids identification of the precise methods efficient in altering conduct (59). The CALO-RE (Coventry, Aberdeen, and London – Refined) taxonomy was used to outline the chosen conduct change methods because it was particularly designed to explain bodily exercise and wholesome consuming interventions (59).
For every of the chosen conduct change methods, it was then determined how they are going to be delivered to the goal inhabitants. Number of conduct change methods and their supply mode was knowledgeable by way of evidence-based evaluation of literature related to bodily exercise within the acute most cancers remedy setting and bodily exercise conduct change concept. It was by way of this decision-making course of – figuring out which conduct change methods to make use of, and the simplest mode of supply – that the elements of CanMOVE have been decided.
Outcomes
Stage 1: Perceive the conduct (steps 1–4)
A abstract of how every of the COM-B elements (functionality, motivation, alternative) contribute to bodily exercise conduct throughout the acute pediatric most cancers setting might be seen in Desk 1. Outcomes from Stage 1 spotlight the varied nature of the boundaries and facilitators to bodily exercise that exist.
Challenges to bodily exercise can range from one youngster to a different relying on their surroundings, most cancers sort, assist community, remedy routine, emotional and bodily states. As well as, boundaries to bodily exercise can change for every particular person youngster over the course of their acute remedy section, which may span many months (55). A toddler/adolescent’s capability to interact in bodily exercise might be restricted by bodily impairments brought on by remedy negative effects but in addition by way of a lack of understanding, worry, and impaired psychological well being. Motivation might be impacted by way of spending massive quantities of time within the hospital surroundings (each in-patient and out-patient setting), diminished bodily potential, a lack of independence and freedom, and an absence of pleasure with motion. Alternatives to be bodily lively might be restricted by way of experiencing isolation from family and friends, residing in unstimulating environments, restricted participation in day by day routines and never gaining access to sports activities tools or toys (55–58). To handle the distinctive traits of every youngster/adolescent and their context, multi-layered, individualized and versatile options are wanted. Options must acknowledge the heterogeneity of this inhabitants. In addition they want to think about the variability that exists for a kid as they transfer by way of totally different remedy phases and have various medical and assist wants.
Many elements recognized within the COM-B mannequin aren’t instantly modifiable. For instance, the bodily structure of a ward or day oncology unit, the need of medical therapies, intravenous traces, useful resource availability, an infection dangers and hospital insurance policies. In figuring out potential pathways to create conduct change, focus was given to figuring out methods to maximise bodily exercise inside these constraints.
Stage 2: Establish intervention choices (steps 5 and 6)
A abstract of the recognized intervention features might be seen in Desk 1. Training, modeling, coaching, enablement, offering incentives and environmental restructuring (50) have been recognized as approaches that would have an effect on bodily exercise conduct.
Stage 3: Establish content material and implementation choices (steps 7 and eight)
Based mostly on stage 1 and a pair of, 15 behavioral change methods to implement inside CanMOVE have been recognized. Desk 2 outlines CanMOVE’s intervention elements, how they are going to be delivered, and the conduct change methods chosen. Additionally depicted are how every element is linked to the beforehand recognized intervention features.
“Purpose setting” and “self-monitoring” have been recognized as key methods. Decreased motivation and self-efficacy are generally reported boundaries to bodily exercise (60). Giving kids and adolescents the means to set objectives and monitor progress in actual time creates a way of management that’s hardly ever afforded in different facets of their care (61). For supply, exercise displays have been chosen. Exercise displays may also be used to use quite a lot of conduct change methods (62, 63). They’re more and more used throughout the pediatric settings (42, 64–67) and literature helps their use in motivating bodily exercise conduct, particularly as a part of a broader intervention plan (68). Utilizing exercise displays to quantify bodily exercise through day by day steps gives kids/adolescents with a method to approximate the quantity of bodily exercise they undertake in real-time. It’s acknowledged that day by day steps are one illustration of bodily exercise, not taking account of different parameters corresponding to depth and frequency. Nevertheless, day by day steps are an accessible means by which to set and monitor bodily exercise objectives (69). Slightly than providing assist that depends upon extrinsic motivation and employees supervision, exercise displays can facilitate intrinsic motivation by way of offering a method to self-manage conduct.
“Demonstration” was one other key behavioral change technique recognized. For kids and adolescents with most cancers, an expertise of bodily impairment and diminished alternative for exercise has the potential to result in a perception they’re unable, or it’s unsafe, to interact in bodily exercise. By way of training and collaborating in an lively demonstration session with a skilled healthcare skilled, alternatives for optimistic motion experiences might be recognized. This builds confidence in a baby/adolescent’s personal potential to maneuver.
“Deliberate social assist,” “barrier identification and drawback fixing,” and “motion planning” have been additionally recognized (70–73). Parental assist is a key determinant of bodily exercise conduct in kids and adolescents (74, 75). Within the most cancers remedy setting, detrimental perceptions towards bodily exercise might be strengthened by dad and mom resulting in perpetuating the sick position of the kid/adolescent and a perception bodily exercise is unsafe (76). Mother and father can play a robust protecting and advocacy position within the care of their youngster with most cancers (77). With a purpose to make the most of this influential position, involvement of the household unit was recognized as essential. Facilitating alternative for households to collaborate with their youngster/adolescent as a group offers management over how they interact with bodily exercise, enabling formulation of self-determined options particular to their pursuits and household context.
By way of “environmental restructuring,” CanMOVE goals to encourage members of the medical multidisciplinary group to interact in a baby/adolescent’s bodily exercise objectives. The priorities that exist inside a company can affect a baby/adolescent’s bodily exercise (78). Offering a method for different members of the remedy group to interact might lead to further motivation and alternative for bodily exercise by way of facilitating adjustments in work practices and routines.
The intervention: CanMOVE
The title “CanMOVE” was chosen to advertise the concept even within the context of acute most cancers remedy, kids and adolescents might be bodily lively. It’s a versatile, individualized intervention tailor-made to swimsuit the distinctive, and infrequently altering, context of every youngster/adolescent. The intervention consists of three phases run over 10 weeks: Evaluation, Monitoring and Suggestions (4 weeks), Capability Constructing (2 weeks) and Consolidation (4 weeks) (Determine 2). This system is designed to be applied by a healthcare skilled, termed the “CanMOVE HCP.” This skilled can have particular coaching in train and rehabilitation for kids with most cancers, corresponding to an train physiologist or physiotherapist. The intent is for CanMOVE to run parallel to present hospital or community-based remedy providers. The place acceptable CanMOVE classes might be performed remotely to accommodate each the house and hospital surroundings, and overcome any isolation restrictions.
Section 1: Evaluation, monitoring, and suggestions
This section happens at first (2 weeks) and the tip of the intervention (2 weeks). It consists of goal evaluation of bodily exercise, bodily operate (e.g., gross motor abilities, cardiovascular operate, practical duties) and health-related high quality of life (HRQOL). Every evaluation final result is mentioned with the kid/adolescent and their dad or mum to construct self-awareness of their present stage of bodily exercise and find out about elements contributing to it (i.e., bodily operate and psychological well being). Assessing throughout two time factors gives a possibility to focus on and have fun any enhancements time beyond regulation. The evaluation of bodily operate additionally gives alternative to determine impairments requiring extra intensive therapeutic enter. On this section, referrals might be made to further providers, as an example within the case of a vincristine neuropathy. There may be inadequate proof to assist the choice of final result measures to evaluate bodily operate on this inhabitants (79). Additional psychometric evaluation is required to tell the choice of evaluation instruments that could be utilized on this section.
Section 2: Capability constructing
Theme 1: “Let’s discover a motive so that you can be bodily lively”
Theme 1 explores self-identified motivations towards bodily exercise. Training is individually tailor-made to determine motivating elements for them, and their dad or mum/s. Right here the CanMOVE HCP seeks to outline the broad nature of bodily exercise, re-framing it as one thing that’s achievable, enjoyable, and a part of the on a regular basis routine. The advantages of bodily exercise are additionally mentioned, particularly within the context of most cancers remedy. A booklet particularly about bodily exercise and most cancers remedy is supplied (80). On the conclusion of the session, the kid/adolescent is requested to determine 1–3 the explanation why being bodily lively is essential and helpful for them.
The kid/adolescent and one dad or mum are supplied with an exercise monitor which is used to set an individualized day by day step goal. The day by day steps goal will act to broadly characterize their participation in bodily exercise all through the day. Collectively the kid/adolescent and dad or mum work towards their day by day goal. The preliminary day by day step objective is formulated collaboratively making an allowance for outcomes from the baseline evaluation and present medical administration. Progress towards their objective might be monitored repeatedly in real-time through the exercise monitor. The day by day step objective will probably be displayed of their hospital room (or at house) and communicated to the treating group through their medical file and multi-disciplinary group conferences.
Theme 2: “Let’s discover how one can be extra bodily lively”
Theme 2 entails collaboratively brainstorming how the kid/adolescent might be extra bodily lively of their surroundings, whether or not that be at house or within the hospital setting. Inside this session kids will probably be inspired to mirror upon what bodily exercise is, what they at the moment do, what they’re able to do, and what they wish to do. In doing so, the kid/adolescent is supported to determine new methods they will introduce bodily exercise alternatives into their day by day routine. Recognized methods will intention to mirror the broad nature of ‘bodily exercise’ (25). For instance, this may occasionally embody actions of day by day dwelling, play, a structured train routine, sports activities abilities, strolling, and/or deliberate social interactions and hobbies that may incorporate incidental bodily exercise.
The kid/adolescent will then take part in a bodily exercise session with the CanMOVE HCP. Actions accomplished will probably be tailor-made to the kid/adolescent’s pursuits, remedy, skills, and security restrictions. Solely actions the kid/adolescent can perform independently (or with the help of their dad or mum) will probably be integrated. If tools, toys, know-how, or lively gaming are used, they should be available to the kid/adolescent for unbiased use. This session goals to supply a optimistic motion expertise that’s enjoyable and construct confidence of their potential to maneuver.
Theme 3: “Let’s make a bodily exercise plan”
Theme 3 goals to plan a bodily exercise plan in partnership with the kid/adolescent and dad or mum/s. Inside this session, progress towards their day by day step objective is reviewed. Optimistic reinforcement is supplied in response to the kid/adolescent making makes an attempt to realize the day by day step objective. A listing of boundaries and facilitators to objective attainment are formulated. Elements which can be inside their realm of management are recognized and potential options brainstormed. Right here the day by day step objective might be altered to make it extra achievable or to inspire a problem, a call to be made within the context of upcoming remedy plans. An motion plan will probably be formulated to work towards the day by day steps goal. Motion plan gadgets will comprise individualized methods to help in overcoming recognized boundaries. Duties will probably be agreed upon and applied by the kid/adolescent and dad or mum. The intention right here is to assist households to make unbiased decisions concerning how the kid/adolescent chooses to maneuver, and inspire a shift towards a extra bodily lively day by day routine.
As well as, the CanMOVE HCP will allocate one hour to help implementation of motion plan gadgets over the course of the next week. Motion plan gadgets will contain the broader treating medical and nursing group the place in a position. An instance of a barrier identification and motion plan might be seen in Desk 3. In circumstances the place psychological or bodily impairments are recognized and can’t be addressed adequately throughout the scope of the CanMOVE program, the CanMOVE HCP will collaborate with specialised remedy providers and referrals made as indicated.
Section 3: Consolidation
4 “consolidation” classes will probably be performed to guage and modify intervention methods primarily based on their success in bringing about conduct change. Every week the day by day steps knowledge for the earlier week will probably be mentioned and a brand new objective set for the approaching week. The day by day step objective will intention to extend every week. Nevertheless, to make sure objectives are achievable, it might be maintained or decreased primarily based on particular person circumstances, corresponding to upcoming hospital admissions/discharges, medical therapies and/or setbacks. Any new boundaries and facilitators recognized will probably be mentioned. Success of motion plan methods will probably be reviewed, and gadgets eliminated or added as indicated. An extra one hour of CanMOVE HCP time can be utilized to help in finishing up motion plan gadgets every week.
Outcomes
The first final result of the CanMOVE intervention is to facilitate change in bodily exercise conduct in kids present process acute most cancers remedy. There could also be further potential advantages if CanMOVE is applied in a scientific setting. The potential short- and long-term outcomes, together with their theorized mechanisms of motion might be present in Determine 3. Previous to scientific implementation, CanMOVE should first be piloted for feasibility and bear additional improvement to make sure security, acceptability, and optimum efficacy.
Dialogue
CanMOVE is a posh intervention that takes a novel and proactive strategy to bodily exercise promotion. With a give attention to conduct change, CanMOVE goals to advertise optimistic motion experiences and maximize the household’s capability towards bodily exercise. The design course of was clear, theory-driven and knowledgeable by qualitative knowledge. The Conduct Change Wheel course of necessitated a deep understanding of the goal conduct, inhabitants and surroundings (50). Though time consuming, growing a transparent behavioral analysis particular to the specified inhabitants ensured all subsequent design selections have been related to the inhabitants. The result’s an intervention that targets particular bodily exercise challenges confronted by kids and adolescents throughout the acute most cancers remedy setting. Intervention methods recognized for CanMOVE promote bodily exercise as crucial, satisfying, and achievable within the acute most cancers remedy setting. This attitude is in-line with just lately launched bodily exercise pointers for kids with most cancers (81). Given the complicated determinants of bodily exercise conduct for kids with most cancers, it is very important acknowledge that CanMOVE is just one aspect inside a multi-system strategy required to advertise bodily exercise for this inhabitants.
CanMOVE seeks to enhance, somewhat than exchange specialised remedy providers that present bodily evaluation, intervention, and rehabilitation. With out the provision of therapists to deal with remedy associated bodily impairments (for instance post-surgical impairments, myopathy and neuropathy), kids and adolescents with compromised bodily operate will discover it difficult to be bodily lively. CanMOVE incorporates a mechanism whereby bodily operate is monitored, with referrals made on a necessity foundation. This strategy ensures bodily impairments are recognized and handled promptly, whereas maximizing the effectivity of specialised service provision. Success, nonetheless, depends upon the choice of psychometrically strong final result measures (79), and sufficient providers in place to offer further remedy as wanted. Given the protracted nature of acute most cancers remedy, the supply of monitoring and comply with up after the completion of CanMOVE is one other consideration. The Stoplight program is an instance of a scientific service that makes use of monitoring and focused train provision with optimistic outcomes (82).
Treating organizations have a job to play to make sure hospital environments, skilled providers and employees values are conducive to bodily exercise engagement. The social-ecological mannequin gives a framework to explain the a number of ranges of affect to be thought of in working towards the promotion of optimistic well being behaviors (83). Along with addressing elements on a person and interpersonal stage, there’s a want for change on the organizational stage. CanMOVE invitations treating groups to take part in a baby/adolescent’s bodily exercise promotion, but there are different optimistic adjustments a company might make to assist bodily exercise. These adjustments fall throughout the coverage classes of the Conduct Change Wheel, corresponding to environmental planning, service provision and a evaluation of hospital pointers (50). For instance, usually tools and areas that promote bodily exercise aren’t available to households. Altering remedy environments to permit area and unbiased entry to tools is a optimistic change that would promote bodily exercise. Different examples embody teaching programs for nursing employees on bodily exercise promotion, together with bodily exercise objectives into medical remedy plans, and a evaluation of hospital polies that limit bodily exercise.
Feasibility analysis is a crucial step within the complicated intervention design course of (37). Previous to implementation, CanMOVE will probably be assessed for feasibility in a non-randomized pilot research (84) in opposition to standards designed by Bowen et al. (85). The endeavor of a theoretical strategy to intervention design will assist this analysis. With out clearly outlined “lively components” of the intervention, understanding what labored, and the way, might be tough to isolate. A complete evaluation of feasibility, using qualitative and quantitative knowledge (86), permits a deeper understanding of intervention components corresponding to: which have been applied efficiently, which have been efficient, and the potential mechanisms underlying any noticed adjustments in conduct. It additionally works to reply questions corresponding to how properly an intervention matches inside a scientific setting and the way acceptable it’s. Addressing these questions is crucial to tell future intervention improvement selections and scientific implementation methods. In depth evaluation of the boundaries and facilitators to bodily exercise reported by members throughout the pilot research will even assist the inform future intervention improvement selections, and information potential adjustments to the surroundings and providers. Future design concerns for CanMOVE will embody when to time the intervention, which final result measures to make use of, find out how to interact the multi-disciplinary group, and the way adjustments of conduct adjustments could also be maintained over the whole size of acute remedy and into survivorship (87).
CanMOVE endeavors to advertise optimistic bodily exercise experiences by way of maximizing a baby/adolescent’s capability, motivation and alternatives for motion. It goals to vary how dad and mom, kids and adolescents take into consideration bodily exercise. Outcomes will in the end inform the implementation of providers throughout the pediatric most cancers setting. The sort of intervention, nonetheless, can’t stand alone. Significant change depends upon organizations offering specialised providers and environments that promote and facilitate participation in bodily exercise. The theoretical design course of underpinning the design of CanMOVE is a vital stepping-stone towards understanding find out how to enhance bodily exercise participation for kids and adolescents on this setting. It additionally has potential utility to different pediatric persistent well being populations the place bodily exercise participation is challenged within the hospital setting.
Information availability assertion
The unique contributions introduced on this research are included within the article, additional inquiries might be directed to the corresponding creator.
Creator contributions
All authors listed have made a considerable, direct, and mental contribution to the work, and accepted it for publication.
Funding
This work was supported by an Australian Authorities Analysis Coaching Program Scholarship by way of La Trobe College, a Ph.D. top-up scholarship by way of the Murdoch Kids’s Analysis Institute, and a analysis grant supplied by way of the charity organisation Little Massive Steps.
Battle of curiosity
The authors declare that the analysis was performed within the absence of any industrial or monetary relationships that may very well be construed as a possible battle of curiosity.
The dealing with editor declared a previous co-authorship with one of many authors SG.
Writer’s word
All claims expressed on this article are solely these of the authors and don’t essentially characterize these of their affiliated organizations, or these of the writer, the editors and the reviewers. Any product that could be evaluated on this article, or declare that could be made by its producer, will not be assured or endorsed by the writer.
References
1. Deisenroth A, Söntgerath R, Schuster AJ, von Busch C, Huber G, Eckert Ok, et al. Muscle power and high quality of life in sufferers with childhood most cancers at early section of main remedy. Pediatr Hematol Oncol. (2016) 33:393–407.
2. Elmantaser M, Stewart G, Younger D, Duncan R, Gibson B, Ahmed S. Skeletal morbidity in kids receiving chemotherapy for acute lymphoblastic leukaemia. Arch Dis Youngster. (2010) 95:805–9.
3. Fuemmeler BF, Pendzich MK, Clark Ok, Lovelady C, Rosoff P, Blatt J, et al. Food plan, bodily exercise, and physique composition adjustments throughout the first yr of remedy for childhood acute leukemia and lymphoma. J Pediatr Hematol Oncol. (2013) 35:437–43. doi: 10.1097/MPH.0b013e318279cd3e
PubMed Summary | CrossRef Full Textual content | Google Scholar
4. Lavoie Smith EM, Li L, Chiang C, Thomas Ok, Hutchinson RJ, Wells EM, et al. Patterns and severity of vincristine-induced peripheral neuropathy in kids with acute lymphoblastic leukemia. J Peripher Nerv Syst. (2015) 20:37–46.
5. Thorsteinsson T, Larsen HB, Schmiegelow Ok, Factor LF, Krustrup P, Pedersen MT, et al. Cardiorespiratory health and bodily operate in kids with most cancers from analysis all through remedy. BMJ Open Sport Exerc Med. (2017) 3:e000179. doi: 10.1136/bmjsem-2016-000179
PubMed Summary | CrossRef Full Textual content | Google Scholar
6. Ness KK, Kaste SC, Zhu L, Pui CH, Jeha S, Nathan PC, et al. Skeletal, neuromuscular and health impairments amongst kids with newly identified acute lymphoblastic leukemia. Leuk Lymphoma. (2015) 56:1004–11. doi: 10.3109/10428194.2014.944519
PubMed Summary | CrossRef Full Textual content | Google Scholar
7. Bhakta N, Liu Q, Ness KK, Baassiri M, Eissa H, Yeo F, et al. The cumulative burden of surviving childhood most cancers: an preliminary report from the St Jude lifetime cohort research (SJLIFE). Lancet. (2017) 390:2569–82.
8. Ness KK, Leisenring WM, Huang S, Hudson MM, Gurney JG, Whelan Ok, et al. Predictors of inactive life-style amongst grownup survivors of childhood most cancers: a report from the childhood most cancers survivor research. Most cancers. (2009) 115:1984–94.
9. Smith WA, Li C, Nottage KA, Mulrooney DA, Armstrong GT, Lanctot JQ, et al. Way of life and metabolic syndrome in grownup survivors of childhood most cancers: a report from the St. Jude lifetime cohort research. Most cancers. (2014) 120:2742–50.
10. Baade PD, Youlden DR, Valery PC, Hassall T, Ward L, Inexperienced AC, et al. Traits in incidence of childhood most cancers in Australia, 1983–2006. Br J Most cancers. (2010) 102:620–6. doi: 10.1038/sj.bjc.6605503
PubMed Summary | CrossRef Full Textual content | Google Scholar
11. Carson V, Stone M, Faulkner G. Patterns of sedentary conduct and weight standing amongst kids. Pediatr Exerc Sci. (2014) 26:95–102.
12. Pellegrini AD, Smith PK. Bodily exercise play: the character and performance of a uncared for facet of play. Youngster Dev. (1998) 69:577–98.
13. Lam KK, Li WH, Chiu SY, Chan GC. The affect of most cancers and its remedy on bodily exercise ranges and high quality of life amongst younger Hong Kong Chinese language most cancers sufferers. Eur J Oncol Nurs. (2016) 21:83–9. doi: 10.1016/j.ejon.2016.01.007
PubMed Summary | CrossRef Full Textual content | Google Scholar
14. Winter C, Müller C, Brandes M, Brinkmann A, Hoffmann C, Hardes J, et al. Stage of exercise in kids present process most cancers remedy. Pediatr Blood Most cancers. (2009) 53:438–43.
15. Hochhauser D, Tobias JS. Most cancers and Its Administration. Somerset: John Wiley & Sons, Included (2014).
16. Stout NL, Baima J, Swisher AK, Winters-Stone KM, Welsh J. A scientific evaluation of train systematic opinions within the most cancers literature (2005-2017). PM R. (2017) 9:S347–84. doi: 10.1016/j.pmrj.2017.07.074
PubMed Summary | CrossRef Full Textual content | Google Scholar
17. Myers RM, Balsamo L, Lu X, Devidas M, Starvation SP, Carroll WL, et al. A potential research of tension, melancholy, and behavioral adjustments within the first yr after a analysis of childhood acute lymphoblastic leukemia. Most cancers. (2014) 120:1417–25. doi: 10.1002/cncr.28578
PubMed Summary | CrossRef Full Textual content | Google Scholar
18. White J, Flohr JA, Winter SS, Vener J, Feinauer LR, Ransdell LB. Potential advantages of bodily exercise for kids with acute lymphoblastic leukaemia. Dev Neurorehabil. (2005) 8:53–8.
19. Friedman DN, Tonorezos ES, Cohen P. Diabetes and metabolic syndrome in survivors of childhood most cancers. Horm Res Paediatr. (2019) 91:118–27.
20. Morales JS, Valenzuela PL, Rincón-Castanedo C, Takken T, Fiuza-Luces C, Santos-Lozano A, et al. Train coaching in childhood most cancers: a scientific evaluation and meta-analysis of randomized managed trials. Most cancers Deal with Rev. (2018) 70:154–67. doi: 10.1016/j.ctrv.2018.08.012
PubMed Summary | CrossRef Full Textual content | Google Scholar
21. Klika R, Tamburini A, Galanti G, Mascherini G, Stefani L. The position of train in pediatric and adolescent cancers: a evaluation of assessments and ideas for scientific implementation. J Funct Morphol Kinesiol. (2018) 3:7.
22. Baumann FT, Bloch W, Beulertz J. Scientific train interventions in pediatric oncology: a scientific evaluation. Pediatr Res. (2013) 74:366–74.
23. Wurz A, Daeggelmann J, Albinati N, Kronlund L, Chamorro-Vina C, Culos-Reed SN. Bodily exercise applications for kids identified with most cancers: a world environmental scan. Help Care Most cancers. (2019) 27:1153. doi: 10.1007/s00520-019-04669-5
PubMed Summary | CrossRef Full Textual content | Google Scholar
24. Grimshaw SL, Taylor NF, Shields N. The feasibility of bodily exercise interventions throughout the intense remedy section for kids and adolescents with most cancers: a scientific evaluation. Pediatr Blood Most cancers. (2016) 63:1586–93. doi: 10.1002/pbc.26010
PubMed Summary | CrossRef Full Textual content | Google Scholar
25. Caspersen CJ, Powell KE, Christenson GM. Bodily exercise, train, and bodily health: definitions and distinctions for health-related analysis. Public Well being Rep. (1985) 100:126–31.
26. Corr AM, Liu W, Bishop M, Pappo A, Srivastava DK, Neel M, et al. Feasibility and practical outcomes of kids and adolescents present process preoperative chemotherapy previous to a limb-sparing process or amputation. Rehabil Oncol. (2017) 35:38–45.
27. Fiuza-Luces C, Padilla JR, Soares-Miranda L, Santana-Sosa E, Quiroga JV, Santos-Lozano A, et al. Train intervention in pediatric sufferers with strong tumors: the bodily exercise in pediatric most cancers trial. Med Sci Sports activities Exerc. (2017) 49:223–30.
28. Gohar SF, Comito M, Value J, Marchese V. Feasibility and dad or mum satisfaction of a bodily remedy intervention program for kids with acute lymphoblastic leukemia within the first 6 months of medical remedy. Pediatr Blood Most cancers. (2011) 56:799–804. doi: 10.1002/pbc.22713
PubMed Summary | CrossRef Full Textual content | Google Scholar
29. Hartman A, te Winkel ML, van Beek RD, de Muinck Keizer-Schrama SM, Kemper HC, Hop WC, et al. A randomized trial investigating an train program to forestall discount of bone mineral density and impairment of motor efficiency throughout remedy for childhood acute lymphoblastic leukemia. Pediatr Blood Most cancers. (2009) 53:64–71. doi: 10.1002/pbc.21942
PubMed Summary | CrossRef Full Textual content | Google Scholar
30. Winter C, Müller C, Hardes J, Gosheger G, Boos J, Rosenbaum D. The impact of individualized train interventions throughout remedy in pediatric sufferers with a malignant bone tumor. Help Care Most cancers. (2013) 21:1629–36.
31. Zucchetti G, Rossi F, Chamorro Vina C, Bertorello N, Fagioli F. Train program for kids and adolescents with leukemia and lymphoma throughout remedy: a complete evaluation. Pediatric Blood Most cancers. (2018) 65:e26924.
32. Rustler, V, Hagerty M, Daeggelmann J, Marjerrison S, Bloch W, Baumann FT. Train interventions for sufferers with pediatric most cancers throughout inpatient acute care: a scientific evaluation of literature. Pediatr Blood Most cancers. (2017) 64:e26567 doi: 10.1002/pbc.26567
PubMed Summary | CrossRef Full Textual content | Google Scholar
33. Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJL. Bodily train coaching interventions for kids and younger adults throughout and after remedy for childhood most cancers. Cochrane Libr. (2013) 4:CD008796.
34. Wurz A, McLaughlin E, Chamorro Viña C, Grimshaw SL, Hamari L, Götte M, et al. Advancing the sphere of pediatric train oncology: analysis and innovation wants. Curr Oncol. (2021) 28:619–29. doi: 10.3390/curroncol28010061
PubMed Summary | CrossRef Full Textual content | Google Scholar
35. Brown MC, Sharp L, Sniehotta FF, Skinner R, Araújo-Soares V. The event of well being behaviour change interventions for childhood most cancers survivors: the necessity for a behavioural science strategy. Pediatr Blood Most cancers. (2020) 67:e28500.
36. Cross A, Howlett N, Sheffield D. Social ecological interventions to extend bodily exercise in kids and younger individuals dwelling with and past most cancers: a scientific evaluation. Psychol Well being. (2020) 35:1477–96. doi: 10.1080/08870446.2020.1759601
PubMed Summary | CrossRef Full Textual content | Google Scholar
37. Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M. Growing and evaluating complicated interventions: the brand new medical analysis council steering. BMJ. (2008) 337:a1655. doi: 10.1136/bmj.a1655
PubMed Summary | CrossRef Full Textual content | Google Scholar
38. Buchan DS, Ollis S, Thomas NE, Baker JS. Bodily exercise behaviour: an summary of present and emergent theoretical practices. J Obes. (2012) 2012:546459. doi: 10.1155/2012/546459
PubMed Summary | CrossRef Full Textual content | Google Scholar
39. Imms C. Kids with cerebral palsy take part: a evaluation of the literature. Disabil Rehabil. (2008) 30:1867–84.
40. Ferreira I, Van Der Horst Ok, Wendel-Vos W, Kremers S, Van Lenthe FJ, Brug J. Environmental correlates of bodily exercise in youth – a evaluation and replace. Obes Rev. (2007) 8:129–54.
41. Cox CL, Zhu L, Kaste SC, Srivastava Ok, Barnes L, Nathan PC, et al. Modifying bone mineral density, bodily operate, and high quality of life in kids with acute lymphoblastic leukemia. Pediatr Blood Most cancers. (2017) 65:e26929. doi: 10.1002/pbc.26929
PubMed Summary | CrossRef Full Textual content | Google Scholar
42. Götte M, Kesting SV, Gerss J, Rosenbaum D, Boos J. Feasibility and results of a home-based intervention utilizing exercise trackers on achievement of particular person objectives, high quality of life and motor efficiency in sufferers with paediatric most cancers. BMJ Open Sport Exerc Med. (2018) 4:e000322. doi: 10.1136/bmjsem-2017-000322
PubMed Summary | CrossRef Full Textual content | Google Scholar
43. Lam KKW, Li WHC, Chung OK, Ho KY, Chiu SY, Lam HS, et al. An built-in experiential coaching programme with teaching to advertise bodily exercise, and cut back fatigue amongst kids with most cancers: a randomised managed trial. Affected person Educ Couns. (2018) 101:1947–56. doi: 10.1016/j.pec.2018.07.008
PubMed Summary | CrossRef Full Textual content | Google Scholar
44. Nielsen MKF, Christensen JF, Frandsen TL, Thorsteinsson T, Andersen LB, Christensen KB, et al. Results of a bodily exercise program from analysis on cardiorespiratory health in kids with most cancers: a nationwide non-randomized managed trial. BMC Med. (2020) 18:175. doi: 10.1186/s12916-020-01634-6
PubMed Summary | CrossRef Full Textual content | Google Scholar
45. Skivington Ok, Matthews L, Simpson S, Craig P, Baird J, Blazeby J, et al. A brand new framework for growing and evaluating complicated interventions: replace of medical analysis council steering. BMJ. (2021) 374:n2061. doi: 10.1136/bmj.n2061
PubMed Summary | CrossRef Full Textual content | Google Scholar
46. O’Cathain A, Croot L, Duncan E, Rousseau N, Sworn Ok, Turner KM, et al. Steering on find out how to develop complicated interventions to enhance well being and healthcare. BMJ Open. (2019) 9:e029954. doi: 10.1136/bmjopen-2019-029954
PubMed Summary | CrossRef Full Textual content | Google Scholar
47. Michie S, Abraham C. Interventions to vary well being behaviours: evidence-based or evidence-inspired? Psychol Well being. (2004) 19:29–49.
48. Michie S, Johnston M, Francis J, Hardeman W, Eccles M. From concept to intervention: mapping theoretically derived behavioural determinants to behavior change methods. Appl Psychol. (2008) 57:660–80.
49. Willmott TJ, Pang B, Rundle-Thiele S. Functionality, alternative, and motivation: an throughout contexts empirical examination of the COM-B mannequin. BMC Public Well being. (2021) 21:1014. doi: 10.1186/s12889-021-11019-w
PubMed Summary | CrossRef Full Textual content | Google Scholar
50. Michie S, Van Stralen MM, West R. The behaviour change wheel: a brand new methodology for characterising and designing behaviour change interventions. Implement Sci. (2011) 6:1–12.
51. Kinnear FJ, Wainwright E, Bourne JE, Lithander FE, Hamilton-Defend J, Searle A. The event of a concept knowledgeable behaviour change intervention to enhance adherence to dietary and bodily exercise remedy pointers in people with familial hypercholesterolaemia (FH). BMC Well being Serv Res. (2020) 20:27. doi: 10.1186/s12913-019-4869-4
PubMed Summary | CrossRef Full Textual content | Google Scholar
52. Martin, R, Murtagh EM. An intervention to enhance the bodily exercise ranges of kids: design and rationale of the ‘lively school rooms’ cluster randomised managed trial. Contemp Clin Trials. (2015) 41:180–91. doi: 10.1016/j.cct.2015.01.019
PubMed Summary | CrossRef Full Textual content | Google Scholar
53. Murtagh E, Barnes A, McMullen J, Morgan P. Moms and teenage daughters strolling to well being: utilizing the behaviour change wheel to develop an intervention to enhance adolescent ladies’ bodily exercise. Public Well being. (2018) 158:37–46. doi: 10.1016/j.puhe.2018.01.012
PubMed Summary | CrossRef Full Textual content | Google Scholar
54. Webb J, Foster J, Poulter E. Rising the frequency of bodily exercise very transient recommendation for most cancers sufferers. Growth of an intervention utilizing the behaviour change wheel. Public Well being. (2016) 133:45–56. doi: 10.1016/j.puhe.2015.12.009
PubMed Summary | CrossRef Full Textual content | Google Scholar
55. Grimshaw SL, Taylor NF, Mechinaud F, Conyers R, Shields N. Bodily exercise for kids present process acute most cancers remedy: a qualitative research of parental views. Pediatr Blood Most cancers. (2020) 67:e28264.
56. Lam KK, Ho Cheung William L, Ho KY, Chung OK, Chan CF. Elements contributing to the low bodily exercise stage for Hong Kong Chinese language kids hospitalised with most cancers: an exploratory research. J Clin Nurs. (2017) 26:190–201. doi: 10.1111/jocn.13495
PubMed Summary | CrossRef Full Textual content | Google Scholar
57. Gotte M, Kesting S, Winter C, Rosenbaum D, Boos J. Expertise of boundaries and motivations for bodily actions and train throughout remedy of pediatric sufferers with most cancers. Pediatr Blood Most cancers. (2014) 61:1632–7.
58. Thorsteinsson T, Schmiegelow Ok, Factor LF, Andersen LB, Helms AS, Ingersgaard MV, et al. Classmates inspire childhood most cancers sufferers to take part in bodily exercise throughout remedy: a qualitative research. Eur J Most cancers Care (Engl). (2019) 28:e13121.
59. Michie S, Ashford S, Sniehotta FF, Dombrowski SU, Bishop A, French DP. A refined taxonomy of behaviour change methods to assist individuals change their bodily exercise and wholesome consuming behaviours: the CALO-RE taxonomy. Psychol Well being. (2011) 26:1479–98. doi: 10.1080/08870446.2010.540664
PubMed Summary | CrossRef Full Textual content | Google Scholar
60. Bar-Mor G, Bar-Tal Y, Krulik T, Zeevi B. Self-efficacy and bodily exercise in adolescents with trivial, gentle, or average congenital cardiac malformations. Cardiol Younger. (2000) 10:561–6. doi: 10.1017/S1047951100008829
PubMed Summary | CrossRef Full Textual content | Google Scholar
61. Gibbins J, Steinhardt Ok, Beinart H. A scientific evaluation of qualitative research exploring the expertise of fogeys whose youngster is identified and handled for most cancers. J Pediatr Oncol Nurs. (2012) 29:253–71. doi: 10.1177/1043454212452791
PubMed Summary | CrossRef Full Textual content | Google Scholar
62. Lyons EJ, Lewis ZH, Mayrsohn BG, Rowland JL. Conduct change methods applied in digital life-style exercise displays: a scientific content material evaluation. J Med Web Res. (2014) 16:e192. doi: 10.2196/jmir.3469
PubMed Summary | CrossRef Full Textual content | Google Scholar
63. Mercer Ok, Li M, Giangregorio L, Burns C, Grindrod Ok. Conduct change methods current in wearable exercise trackers: a vital evaluation. JMIR Mhealth Uhealth. (2016) 4:e40. doi: 10.2196/mhealth.4461
PubMed Summary | CrossRef Full Textual content | Google Scholar
64. Le A, Mitchell HR, Zheng DJ, Rotatori J, Fahey JT, Ness KK, et al. A house-based bodily exercise intervention utilizing exercise trackers in survivors of childhood most cancers: a pilot research. Pediatr Blood Most cancers. (2017) 64:387–94. doi: 10.1002/pbc.26235
PubMed Summary | CrossRef Full Textual content | Google Scholar
65. Hooke MC, Gilchrist L, Tanner L, Hart N, Withycombe JS. Use of a health tracker to advertise bodily exercise in kids with acute lymphoblastic leukemia. Pediatr Blood Most cancers. (2016) 63:684–9. doi: 10.1002/pbc.25860
PubMed Summary | CrossRef Full Textual content | Google Scholar
66. Mendoza JA, Baker KS, Moreno MA, Whitlock Ok, Abbey-Lambertz M, Waite A, et al. A fitbit and fb mHealth intervention for selling bodily exercise amongst adolescent and younger grownup childhood most cancers survivors: a pilot research. Pediatr Blood Most cancers. (2017) 64:e26660. doi: 10.1002/pbc.26660
PubMed Summary | CrossRef Full Textual content | Google Scholar
67. Schofield L, Mummery WK, Schofield G. Results of a managed pedometer-intervention trial for low-active adolescent ladies. Med Sci Sports activities Exerc. (2005) 37:1414–20. doi: 10.1249/01.mss.0000174889.89600.e3
PubMed Summary | CrossRef Full Textual content | Google Scholar
68. Sullivan AN, Lachman ME. Conduct change with health know-how in sedentary adults: a evaluation of the proof for growing bodily exercise. Entrance Public Well being. (2017) 4:289. doi: 10.3389/fpubh.2016.00289
PubMed Summary | CrossRef Full Textual content | Google Scholar
69. Kraus WE, Janz KF, Powell KE, Campbell WW, Jakicic JM, Troiano RP, et al. Each day Step counts for measuring bodily exercise publicity and its relation to well being. Med Sci Sports activities Exerc. (2019) 51:1206–12. doi: 10.1249/MSS.0000000000001932
PubMed Summary | CrossRef Full Textual content | Google Scholar
70. Michie S, Abraham C, Whittington C, McAteer J, Gupta S. Efficient methods in wholesome consuming and bodily exercise interventions: a meta-regression. Well being Psychol. (2009) 28:690–701. doi: 10.1037/a0016136
PubMed Summary | CrossRef Full Textual content | Google Scholar
71. Greaves CJ, Sheppard KE, Abraham C, Hardeman W, Roden M, Evans PH, et al. Systematic evaluation of opinions of intervention elements related to elevated effectiveness in dietary and bodily exercise interventions. BMC Public Well being. (2011) 11:119. doi: 10.1186/1471-2458-11-119
PubMed Summary | CrossRef Full Textual content | Google Scholar
72. Kahn EB, Ramsey LT, Brownson RC, Heath GW, Howze EH, Powell KE, et al. The effectiveness of interventions to extend bodily exercise. A scientific evaluation. Am J Prev Med. (2002) 22:73–107. doi: 10.1016/S0749-3797(02)00434-8
73. Rhodes RE, Pfaeffli LA. Mediators of bodily exercise behaviour change amongst grownup non-clinical populations: a evaluation replace. Int J Behav Nutr Phys Act. (2010) 7:1–11. doi: 10.1186/1479-5868-7-37
PubMed Summary | CrossRef Full Textual content | Google Scholar
74. Trost SG, Loprinzi PD. Parental influences on bodily exercise conduct in kids and adolescents: a short evaluation. Am J Way of life Med. (2011) 5:171–81. doi: 10.1177/1559827610387236
76. Le A, Li F, Mitchell HR, Kadan-Lottick N. Train practices, preferences, and boundaries within the pediatric oncology inhabitants. Pediatr Blood Most cancers. (2015) 62:2177–84. doi: 10.1186/s12913-016-1423-5
PubMed Summary | CrossRef Full Textual content | Google Scholar
77. Kars MC, Duijnstee MSH, Pool A, Van Delden JJM, Grypdonck MHF. Being there: parenting the kid with acute lymphoblastic leukaemia. J Clin Nurs. (2008) 17:1553–62. doi: 10.1111/j.1365-2702.2007.02235.x
PubMed Summary | CrossRef Full Textual content | Google Scholar
78. Keats MR, Culos-Reed SN, Courneya KS. An examination of the beliefs, attitudes and counselling practices of paediatric oncologists towards bodily exercise: a provincial survey. Paediatr Youngster Well being. (2007) 12:289–93. doi: 10.1093/pch/12.4.289
PubMed Summary | CrossRef Full Textual content | Google Scholar
79. Grimshaw SL, Taylor NF, Mechinaud F, Shields N. Evaluation of bodily operate in kids with most cancers: a scientific evaluation. Pediatr Blood Most cancers. (2018) 65:e27369. doi: 10.1002/pbc.27369
PubMed Summary | CrossRef Full Textual content | Google Scholar
81. Wurz A, McLaughlin E, Lategan C, Chamorro Viña C, Grimshaw SL, Hamari L, et al. The worldwide pediatric oncology train pointers (iPOEG). Transl Behav Med. (2021) 11:1915–22. doi: 10.1093/tbm/ibab028
PubMed Summary | CrossRef Full Textual content | Google Scholar
82. Tanner LR, Hooke MC. Enhancing physique operate and minimizing exercise limitations in pediatric leukemia survivors: the lasting affect of the stoplight program. Pediatr Blood Most cancers. (2019) 66:e27596. doi: 10.1002/pbc.27596
PubMed Summary | CrossRef Full Textual content | Google Scholar
84. Eldridge SM, Lancaster GA, Campbell MJ, Thabane L, Hopewell S, Coleman CL, et al. Defining feasibility and pilot research in preparation for randomised managed trials: improvement of a conceptual framework. PLoS One. (2016) 11:e0150205. doi: 10.1371/journal.pone.0150205
PubMed Summary | CrossRef Full Textual content | Google Scholar
85. Bowen DJ, Kreuter M, Spring B, Cofta-Woerpel L, Linnan L, Weiner D, et al. How we design feasibility research. Am J Prev Med. (2009) 36:452–7. doi: 10.1016/j.amepre.2009.02.002
PubMed Summary | CrossRef Full Textual content | Google Scholar
86. Moore GF, Audrey S, Barker M, Bond L, Bonell C, Hardeman W, et al. Course of analysis of complicated interventions: medical analysis council steering. BMJ. (2015) 350:h1258. doi: 10.1136/bmj.h1258
PubMed Summary | CrossRef Full Textual content | Google Scholar
87. Grimmett C, Foster C, Bradbury Ok, Lally P, Might CR, Myall M, et al. Exploring upkeep of bodily exercise behaviour change amongst individuals dwelling with and past gastrointestinal most cancers: a cross-sectional qualitative research and typology. BMJ Open. (2020) 10:e037136. doi: 10.1136/bmjopen-2020-037136
PubMed Summary | CrossRef Full Textual content | Google Scholar






