Opposite to the widespread perception that weight problems will increase the danger of breast most cancers, a brand new examine has discovered that ladies with regular weight needs to be extra cautious about breast most cancers than overweight girls earlier than menopause. This examine, performed by a joint analysis workforce from Kangbuk Samsung Hospital’s Healthcare Information Middle and Hanyang College, adopted over 120,000 girls aged 20 to 54 for a median of 6.7 years.
These girls underwent well being screenings on the Kangbuk Samsung Hospital’s Complete Examination Middle from 2011 to 2019. The analysis workforce analyzed the connection between physique composition metrics akin to physique fats proportion, physique mass index (BMI), waist circumference, and muscle mass, and the incidence of breast most cancers.
The outcomes revealed that for premenopausal girls, a ten% improve in physique fats proportion was related to a 12% lower within the danger of breast most cancers. Particularly, with each one-unit improve in BMI (kg/m2), waist circumference (cm), and physique fats mass (kg), the danger of breast most cancers decreased by 1-4%. In distinction, muscle mass confirmed no important correlation with breast most cancers danger.
It’s usually identified that extreme publicity to the feminine hormone estrogen will increase the chance of creating breast most cancers. Subsequently, weight problems has additionally been acknowledged as a significant danger issue for breast most cancers as a result of fats cells, along with the ovaries, secrete estrogen.
Nonetheless, this typical knowledge is extra relevant to postmenopausal girls and could also be distinctive for youthful, premenopausal girls, as highlighted by this examine. The researchers identified that overweight premenopausal girls might need decrease publicity to estrogen because of elements akin to irregular menstrual cycles, which cut back ovarian estrogen secretion.
Professor Jang Yoo-Soo from Kangbuk Samsung Hospital suggested, “Though the danger of breast most cancers might lower, it’s essential to take care of an applicable weight for total well being, as weight problems will increase the danger of different power illnesses akin to diabetes, hyperlipidemia, and cardiovascular illnesses.”
The findings of this examine had been revealed in «JAMA Community Open», a journal of the American Medical Affiliation (AMA).
