About this examine
Cancers like leukemia and lymphoma are sometimes handled with chemotherapy. Typically, the most cancers comes again, or relapses, after therapy. In different circumstances, the most cancers doesn’t enhance after therapy.
Docs could deal with robust cancers like these with a bone marrow transplant, additionally referred to as a hematopoietic (blood) cell transplant. The process begins with chemotherapy (sturdy most cancers medication) to kill the affected person’s bone marrow and make room for the transplanted cells. Subsequent, medical doctors take away cells from a donor and inject them into the affected person. These donor blood cells develop within the affected person and make new blood cells to combat the most cancers.
The most effective donor for the sort of transplant is a brother or sister who matches the affected person’s immune sort. If the affected person doesn’t have a brother or sister who is an acceptable donor, one other donor could also be used. Different donors could embrace somebody who just isn’t associated to the affected person or a member of the family who is simply a partial match.
This medical trial will deal with sufferers whose most cancers has come again or worsened regardless of having a earlier bone marrow transplant. On this St. Jude examine, medical doctors will carry out a brand new bone marrow transplant utilizing donor cells from a member of the family who’s a partial match for the affected person’s immune sort. The sort of transplant is known as a haploidentical transplant.
Eligibility overview
- 21 years outdated and youthful
- Recognized with one of many following that has come again after a earlier bone marrow transplant or didn’t enhance after bone marrow transplant
- Acute lymphoblastic leukemia (ALL)
- Acute myeloid leukemia
- Myeloid sarcoma
- Continual myeloid leukemia (CML)
- Juvenile myelomonocytic leukemia (JMML)
- Myelodysplastic syndrome (MDS)
- Non-Hodgkin lymphoma (NHL)
- Has a member of the family who is an acceptable stem cell donor