TUESDAY, July 9, 2024 (HealthDay Information) — For transgender ladies receiving estrogen, the median prostate-specific antigen (PSA) degree is 0.02 ng/mL, in line with a analysis letter printed on-line June 26 within the Journal of the American Medical Affiliation.
Farnoosh Nik-Ahd, M.D., from the College of California, San Francisco, and colleagues decided PSA values amongst a nationwide cohort of transgender ladies with out identified prostate most cancers receiving estrogen. The inclusion standards have been met by 210 sufferers who underwent 852 PSA checks.
The researchers discovered that the median PSA degree was 0.02 ng/mL, and the ninety fifth percentile worth was 0.6 ng/mL. In 36 p.c of sufferers, PSA ranges have been undetectable (23 and 49 p.c of these with out and with orchiectomy, respectively). In sensitivity analyses utilizing first PSA degree and the median of all PSA ranges per affected person, the PSA distributions have been comparable (median, 0.08 and 0.06 ng/mL; ninety fifth percentile, 0.7 and 0.5 ng/mL). Throughout the cohort, the best PSA degree was 2.21 ng/mL.
“On this research, PSA values have been very low amongst transgender ladies receiving estrogen, suggesting that the historic lower level of 4 ng/mL, typically used as a threshold for additional analysis, is probably going far too excessive a threshold for this inhabitants,” the authors write.
One creator disclosed ties to the biopharmaceutical trade.
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