PSA Ranges Very Low Amongst Transgender Adults Receiving Estrogen

(HealthDay Information) — For transgender people receiving estrogen, the median prostate-specific antigen (PSA) degree is 0.02 ng/mL, based on a analysis letter revealed on-line within the Journal of the American Medical Affiliation.

Farnoosh Nik-Ahd, MD, from the College of California, San Francisco, and colleagues decided PSA values amongst a nationwide cohort of transgender adults with out recognized prostate most cancers receiving estrogen. The inclusion standards have been met by 210 sufferers who underwent 852 PSA checks.

The researchers discovered that the median PSA degree was 0.02 ng/mL, and the ninety fifth percentile worth was 0.6 ng/mL. In 36% of sufferers, PSA ranges have been undetectable (23% and 49% of these with out and with orchiectomy, respectively). In sensitivity analyses utilizing first PSA degree and the median of all PSA ranges per affected person, the PSA distributions have been related (median, 0.08 and 0.06 ng/mL; ninety fifth percentile, 0.7 and 0.5 ng/mL). Inside the cohort, the best PSA degree was 2.21 ng/mL.

“On this examine, PSA values have been very low amongst transgender ladies receiving estrogen, suggesting that the historic reduce level of 4 ng/mL, typically used as a threshold for additional analysis, is probably going far too excessive a threshold for this inhabitants,” the authors write.

One creator disclosed ties to the biopharmaceutical business.