Power myeloid leukemia identified in being pregnant: administration and end result of 87 sufferers reported to the European LeukemiaNet worldwide registry


  • Power granulocytic leukaemia: comparability of radiotherapy and busulphan remedy. Report of the Medical Analysis Council’s working social gathering for therapeutic trials in leukaemia. Br Med J. 1968;1:201–8

  • Legislation AD, Kim DDH, Lipton JH. Being pregnant: a part of life in persistent myelogenous leukemia. Leuk Lymphoma. 2017;58:280–7.

    Article 
    PubMed 

    Google Scholar
     

  • Robertson HF, Apperley JF. Therapy of CML in being pregnant. Hematol Am Soc Hematol Educ Program. 2022;2022:123–8.

    Article 

    Google Scholar
     

  • Abruzzese E, Mauro M, Apperley J, Chelysheva E. Tyrosine kinase inhibitors and being pregnant in persistent myeloid leukemia: opinion, proof, and suggestions. Ther Adv Hematol. 2020;11:2040620720966120.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chelysheva E, Turkina A. Dangers and challenges of CML administration throughout being pregnant: searching for a balanced choice. Eur J Hematol. 2019;102:378–9.

    Article 

    Google Scholar
     

  • Berdman E. Household planning and being pregnant in sufferers with persistent myeloid leukemia. Curr Hematol Malignancy Rep. 2023;18:1–7.


    Google Scholar
     

  • Pye SM, Cortes J, Ault P, Hatfield A, Kantarjian H, Pilot R, et al. The results of imatinib on being pregnant end result. Blood. 2008;111:5505–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cortes JE, Abruzzese E, Chelysheva E, Guha M, Wallis N, Apperley JF. The impression of dasatinib on being pregnant outcomes. Am J Hematol. 2015;90:1111–5.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Abruzzese E, Trawinska MM, de Fabritiis P, Baccarani M. Administration of pregnant persistent myeloid leukemia sufferers. Skilled Rev Hematol. 2016;9:781–91.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Cole S, Kantarjian H, Ault P, Cortés JE. Profitable completion of being pregnant in a affected person with persistent myeloid leukemia with out energetic intervention: a case report and assessment of the literature. Clin Lymphoma Myeloma. 2009;9:324–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Iqbal J, Ali Z, Khan AU, Aziz Z. Being pregnant outcomes in sufferers with persistent myeloid leukemia handled with imatinib mesylate: brief report from a growing nation. Leuk Lymphoma. 2014;55:2109–13.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jovelet C, Seck A, Mir O, Simasotchi C, Broutin S, Goffinet F, et al. Variation in transplacental switch of tyrosine kinase inhibitors within the human perfused cotyledon mannequin. Ann Oncol. 2015;26:1500–4.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chelysheva E, Turkina A, Polushkina E, Shmakov R, Zeifman A, Aleshin S, et al. Placental switch of tyrosine kinase inhibitors used for persistent myeloid leukemia remedy. Leuk Lymphoma. 2018;59:733–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Russell MA, Carpenter MW, Akhtar MS, Lagattuta TF, Egorin MJ. Imatinib mesylate and metabolite concentrations in maternal blood, umbilical wire blood, placenta and breast milk. J Perinatol. 2007;27:241–3.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Abruzzese E, Aureli S, Bondanini F, Ciccarone M, Cortis E, Di Paolo A, et al. Power myeloid leukemia and being pregnant: when desires meet actuality. State-of-the-art, administration and end result of 41 instances, nilotinib placental switch. J Clin Med. 2022;11:1801.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cortes JE, Gambacorti-Passerini C, Deininger M, Abruzzese E, De Annuntis L, Brümmendorf TH. Being pregnant outcomes in sufferers handled with bosutinib. Int J Hematol Oncol. 2020;9:IJH26.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Alizadeh H, Jaafar H, Rajnics P, Khan MI, Kajtár B. Consequence of being pregnant in persistent myeloid leukaemia sufferers handled with tyrosine kinase inhibitors: brief report from a single centre. Leuk Res. 2015;39:47–51.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Berveiller P, Andreoli A, Mir O, Anselem O, Delezoide AL, Sauvageon H, et al. A dramatic fetal end result following transplacental switch of dasatinib. Anticancer Medicine. 2012;23:754–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lasica M, Willcox A, Burbury Ok, Ross DM, Branford S, Butler J, et al. The impact of tyrosine kinase inhibitor interruption and interferon use on being pregnant outcomes and long-term illness management in persistent myeloid leukemia. Leuk Lymphoma. 2019;60:1796–802.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Celiloglu M, Altunyurt S, Undar B. Hydroxyurea remedy for persistent myeloid leukemia throughout being pregnant. Acta Obstet Gynecol Scand. 2000;79:803–4.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jain D, Atmapoojya P, Colah R, Lodha P. Sickle cell illness and being pregnant. Mediterr J Hematol Infect Dis. 2019;11:e2019040.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rohilla M, Rai R, Yanamandra U, Chaudhary N, Malhotra P, Varma N, et al. Obstetric issues and administration in persistent myeloid leukemia. Indian J Hematol Blood Transfus. 2016;32:62–6.

    Article 
    PubMed 

    Google Scholar
     

  • Hochhaus A, Baccarani M, Silver RT, Schiffer C, Apperley JF, Cervantes F, et al. European LeukemiaNet 2020 suggestions for treating persistent myeloid leukemia. Leukemia. 2020;34:966–84.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Assi R, Kantarjian H, Keating M, Pemmaraju N, Verstovsek S, Garcia-Manero G, et al. Administration of persistent myeloid leukemia throughout being pregnant amongst sufferers handled with a tyrosine kinase inhibitor: a single-Heart expertise. Leuk Lymphoma. 2021;62:909–17.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Claudiani S, Gatenby A, Szydlo R, Nesr G, Abulafia AS, Palanicawandar R, et al. MR4 sustained for 12 months is related to steady deep molecular responses in persistent myeloid leukemia. Haematologica. 2019;104:2206–14.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pfirrmann M, Baccarani M, Saussele S, Guilhot J, Cervantes F, Ossenkoppele G, et al. Prognosis of long-term survival contemplating disease-specific demise in sufferers with persistent myeloid leukemia. Leukemia. 2016;30:48–56.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ali R, Ozkalemkas F, Kimya Y, Koksal N, Ozkocaman V, Gulten T, et al. Imatinib use throughout being pregnant and breast feeding: a case report and assessment of the literature. Arch Gynecol Obstet. 2009;280:169–75.

    Article 
    PubMed 

    Google Scholar
     

  • Burwick RM, Kuo Ok, Brewer D, Druker BJ. Maternal, fetal, and neonatal imatinib ranges with remedy of persistent myeloid leukemia in being pregnant. Obstet Gynecol. 2017;129:831–4.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Egbe A, Uppu S, Lee S, Stroustrup A, Ho D, Srivastava S. Congenital malformations within the new child inhabitants: a inhabitants research and evaluation of the impact of intercourse and prematurity. Pediatr Neonatol. 2015;56:25–30.

    Article 
    PubMed 

    Google Scholar
     

  • Homma S, Messé SR, Rundek T, Solar YP, Franke J, Davidson Ok, et al. Patent foramen ovale. Nat Rev Dis Prim. 2016;2:15086.

    Article 
    PubMed 

    Google Scholar
     

  • Tripathi R, Mazmudar RS, Knusel KD, Ezaldein HH, Belazarian LT, Bordeaux JS, et al. Influence of congenital cutaneous hemangiomas on new child care in the USA. Arch Dermatol Res. 2021;313:641–51.

    Article 
    PubMed 

    Google Scholar
     

  • Stirnemann J, Villar J, Salomon LJ, Ohuma E, Ruyan P, Altman DG, et al. Worldwide estimated fetal weight requirements of the INTERGROWTH-21st Challenge. Ultrasound Obstet Gynecol. 2017;49:478–86.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Damhuis SE, Ganzevoort W, Gordijn SJ. Irregular fetal progress: small for gestational age, fetal progress restriction, massive for gestational age: definitions and epidemiology. Obstet Gynecol Clin N Am. 2021;48:267–79.

    Article 

    Google Scholar
     

  • Al Kindi S, Dennison D, Pathare A. Imatinib in being pregnant. Eur J Haematol. 2005;74:535–7.

    Article 
    PubMed 

    Google Scholar
     

  • Barron SL. Birthweight and ethnicity. Br J Obstet Gynaecol. 1983;90:289–90.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Urquia ML. Variability in birthweight, birthweight charts, and opposed outcomes: Is the “proper measurement” the best query? Paediatr Perinat Epidemiol. 2019;33:433–5.

    Article 
    PubMed 

    Google Scholar
     

  • Nardozza LM, Caetano AC, Zamarian AC, Mazzola JB, Silva CP, Marçal VM, et al. Fetal progress restriction: present information. Arch Gynecol Obstet. 2017;295:1061–77.

    Article 
    PubMed 

    Google Scholar
     

  • Romo A, Carceller R, Tobajas J. Intrauterine progress retardation (IUGR): epidemiology and etiology. Pediatr Endocrinol Rev. 2009;6:332–6.

    PubMed 

    Google Scholar
     

  • Hehlmann R, Heimpel H, Hasford J, Kolb HJ, Pralle H, Hossfeld DK, et al. Randomized comparability of interferon-alpha with busulfan and hydroxyurea in persistent myelogenous leukemia. The German CML Research Group. Blood. 1994;84:4064–77.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hehlmann R, Lauseker M, Saussele S, Pfirrmann M, Krause S, Kolb HJ, et al. Evaluation of imatinib as first-line remedy of persistent myeloid leukemia: 10-year survival outcomes of the randomized CML research IV and impression of non-CML determinants. Leukemia. 2017;31:2398–406.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hochhaus A, Saglio G, Hughes TP, Larson RA, Kim DW, Issaragrisil S, et al. Lengthy-term advantages and dangers of frontline nilotinib vs imatinib for persistent myeloid leukemia in persistent section: 5-year replace of the randomized ENESTnd trial. Leukemia. 2016;30:1044–54.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cortes JE, Saglio G, Kantarjian HM, Baccarani M, Mayer J, Boque C, et al. Remaining 5-year research outcomes of DASISION: the dasatinib versus imatinib research in treatment-naive persistent myeloid leukemia sufferers trial. J Clin Oncol. 2016;34:2333–40.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Baccarani M, Deininger MW, Rosti G, Hochhaus A, Soverini S, Apperley JF, et al. EuropeanLeukemiaNet suggestions for the administration of persistent myeloid leukemia: 2013. Blood. 2013;122:872–84.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wooden WA, Lee SJ. Malignant hematologic ailments in adolescents and younger adults. Blood. 2011;117:5803–15.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pemmaraju N, Cortes J. Power myeloid leukemia in adolescents and younger adults: affected person traits, outcomes and assessment of the literature. Acta Haematol. 2014;132:298–306.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kalmanti L, Saussele S, Lauseker M, Proetel U, Müller MC, Hanfstein B, et al. Youthful sufferers with persistent myeloid leukemia do properly despite poor prognostic indicators: outcomes from the randomized CML research IV. Ann Hematol. 2014;93:71–80.

    Article 
    PubMed 

    Google Scholar
     

  • Staley EM, Simmons SC, Feldman AZ, Lorenz RG, Marques MB, Williams LA third, et al. Administration of persistent myeloid leukemia within the setting of being pregnant: when is leukocytapheresis acceptable? A case report and assessment of the literature. Transfusion. 2018;58:456–60.

    Article 
    PubMed 

    Google Scholar
     

  • Gangat N, Tefferi A. Myeloproliferative neoplasms and being pregnant: Overview and apply suggestions. Am J Hematol. 2021;96:354–66.

    Article 
    PubMed 

    Google Scholar
     

  • Talpaz M, Mercer J, Hehlmann R. The interferon-alpha revival in CML. Ann Hematol. 2015;94:S195–207.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mubarak AA, Kakil IR, Awidi A, Al-Homsi U, Fawzi Z, Kelta M, et al. Regular end result of being pregnant in persistent myeloid leukemia handled with interferon-alpha in 1st trimester: report of three instances and assessment of the literature. Am J Hematol. 2002;69:115–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kantarjian HM, Deisseroth A, Kurzrock R, Estrov Z, Talpaz M. Power myelogenous leukemia: a concise replace. Blood. 1993;82:691–703.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Quinta´s-Cardama A, Kantarjian HM, Giles F, Verstovsek S. Pegylated interferon remedy for sufferers with Philadelphia chromosome-negative myeloproliferative problems. Thromb Hemost. 2006;32:409–16.

    Article 

    Google Scholar
     

  • Varytė G, Arlauskienė A, Ramašauskaitė D. Being pregnant and a number of sclerosis: an replace. Curr Opin Obstet Gynecol. 2021;33:378–83.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

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