Ophthalmologic manifestations of acute leukemia are heterogeneous

Ophthalmologic manifestations of acute leukemia are heterogeneous and detectable at preliminary presentation or relapse, based on a research printed on-line July 10 within the Annals of Hematology.

Dina N. Laimon, M.D., from Mansoura College in Egypt, and colleagues examined the incidence of various ophthalmological manifestations in newly recognized acute leukemia in a cross-sectional research involving 222 newly recognized acute myeloid and acute lymphoblastic leukemia sufferers (144 and 78, respectively) who offered between January 2022 and February 2023. All sufferers underwent a whole ophthalmic analysis.

The researchers discovered that ophthalmic manifestations have been detected in 43.2% of sufferers. Of those, 1.8% had poor visible acuity. The most typical ocular manifestations have been retinal hemorrhage and Roth spots (19.8 and 17.1%, respectively). Different ophthalmological manifestations included orbital involvement, ocular motility points, subconjunctival hemorrhage, conjunctival chemosis, and lid swelling (3.2, 1.4, 5.9, 0.9, and 4.1%, respectively).

In contrast with acute lymphoblastic leukemia sufferers, acute myeloid leukemia sufferers had a considerably larger frequency of ocular affection, retinal hemorrhages, and Roth spots. A big affiliation was seen for retinal hemorrhage with anemia.

“Cooperation between ophthalmologists and hemato-oncologists is essential for recognizing ocular involvement and illness administration,” the authors write. “We want additional analysis of a bigger cohort of acute leukemia sufferers particularly for survival evaluation to set the document for the prognostic worth of ocular manifestations in such neoplasms.”

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