Intricate results of post-translational modifications in liver most cancers: mechanisms to scientific functions | Journal of Translational Drugs


  • Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. World most cancers statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 nations. CA Most cancers J Clin. 2024;74:229–63. https://doi.org/10.3322/caac.21834.

    Article 
    PubMed 

    Google Scholar
     

  • Wilson JF. Liver most cancers on the rise. Ann Intern Med. 2005;142:1029–32. https://doi.org/10.7326/0003-4819-142-12_part_1-200506210-00024.

    Article 
    PubMed 

    Google Scholar
     

  • Peng J, Lü M, Peng Y, Tang X. World incidence of major liver most cancers by etiology amongst youngsters, adolescents, and younger adults. J Hepatol. 2023;79:e92–4. https://doi.org/10.1016/j.jhep.2023.02.019.

    Article 
    PubMed 

    Google Scholar
     

  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. World most cancers statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 nations. CA Most cancers J Clin. 2018;68:394–424. https://doi.org/10.3322/caac.21492.

    Article 
    PubMed 

    Google Scholar
     

  • Kim BH, Park JW. Epidemiology of liver most cancers in South Korea. Clin Mol Hepatol. 2018;24:1–9. https://doi.org/10.3350/cmh.2017.0112.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen JG, Zhang SW. Liver most cancers epidemic in China: previous, current and future. Semin Most cancers Biol. 2011;21:59–69. https://doi.org/10.1016/j.semcancer.2010.11.002.

    Article 
    PubMed 

    Google Scholar
     

  • Duan XY, Zhang L, Fan JG, Qiao L. NAFLD results in liver most cancers: do we’ve ample proof? Most cancers Lett. 2014;345:230–4. https://doi.org/10.1016/j.canlet.2013.07.033.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li G, Yao Q, Liu P, Zhang H, Liu Y, Li S, et al. Important roles and scientific views of RNA methylation in most cancers. MedComm. 2020;2024(5): e559. https://doi.org/10.1002/mco2.559.

    Article 
    CAS 

    Google Scholar
     

  • Huang PS, Wang LY, Wang YW, Tsai MM, Lin TK, Liao CJ, et al. Analysis and software of drug resistance by biomarkers within the scientific remedy of liver most cancers. Cells. 2023. https://doi.org/10.3390/cells12060869.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nikolaou Okay, Sarris M, Talianidis I. Molecular pathways: the advanced roles of irritation pathways within the growth and remedy of liver most cancers. Clin Most cancers Res. 2013;19:2810–6. https://doi.org/10.1158/1078-0432.Ccr-12-1961.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • He Y, Shi M, Wu X, Ma J, Ng KT, Xia Q, et al. Mutational signature evaluation reveals widespread contribution of pyrrolizidine alkaloid publicity to human liver most cancers. Hepatology. 2021;74:264–80. https://doi.org/10.1002/hep.31723.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bruix J, Han KH, Gores G, Llovet JM, Mazzaferro V. Liver most cancers: approaching a personalised care. J Hepatol. 2015;62:S144–56. https://doi.org/10.1016/j.jhep.2015.02.007.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fu X, Zhang Y, Luo Q, Ju Y, Music G. Concentrating on the mechano-microenvironment and liver most cancers stem cells: a promising therapeutic technique for liver most cancers. Most cancers Biol Med. 2023;20:816–29. https://doi.org/10.20892/j.issn.2095-3941.2023.0229.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xue C, Yao Q, Gu X, Shi Q, Yuan X, Chu Q, et al. Evolving cognition of the JAK-STAT signaling pathway: autoimmune problems and most cancers. Sign Transduct Goal Ther. 2023;8:204. https://doi.org/10.1038/s41392-023-01468-7.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hao L, Li S, Deng J, Li N, Yu F, Jiang Z, et al. The present standing and way forward for PD-L1 in liver most cancers. Entrance Immunol. 2023;14:1323581. https://doi.org/10.3389/fimmu.2023.1323581.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zheng Y, Wang S, Cai J, Ke A, Fan J. The progress of immune checkpoint remedy in major liver most cancers. Biochim Biophys Acta Rev Most cancers. 2021;1876: 188638. https://doi.org/10.1016/j.bbcan.2021.188638.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Anwanwan D, Singh SK, Singh S, Saikam V, Singh R. Challenges in liver most cancers and potential remedy approaches. Biochim Biophys Acta Rev Most cancers. 2020;1873: 188314. https://doi.org/10.1016/j.bbcan.2019.188314.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li X, Ramadori P, Pfister D, Seehawer M, Zender L, Heikenwalder M. The immunological and metabolic panorama in major and metastatic liver most cancers. Nat Rev Most cancers. 2021;21:541–57. https://doi.org/10.1038/s41568-021-00383-9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • de Lope CR, Tremosini S, Forner A, Reig M, Bruix J. Administration of HCC. J Hepatol. 2012;56(Suppl 1):S75-87. https://doi.org/10.1016/s0168-8278(12)60009-9.

    Article 
    PubMed 

    Google Scholar
     

  • Li L, Wang H. Heterogeneity of liver most cancers and personalised remedy. Most cancers Lett. 2016;379:191–7. https://doi.org/10.1016/j.canlet.2015.07.018.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kensler TW, Qian GS, Chen JG, Groopman JD. Translational methods for most cancers prevention in liver. Nat Rev Most cancers. 2003;3:321–9. https://doi.org/10.1038/nrc1076.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Macek B, Forchhammer Okay, Hardouin J, Weber-Ban E, Grangeasse C, Mijakovic I. Protein post-translational modifications in micro organism. Nat Rev Microbiol. 2019;17:651–64. https://doi.org/10.1038/s41579-019-0243-0.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vu LD, Gevaert Okay, De Smet I. Protein language: post-translational modifications speaking to one another. Development Plant Sci. 2018;23:1068–80. https://doi.org/10.1016/j.tplants.2018.09.004.

    Article 
    CAS 

    Google Scholar
     

  • Bradley D. The evolution of post-translational modifications. Curr Opin Genet Dev. 2022;76: 101956. https://doi.org/10.1016/j.gde.2022.101956.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shu F, Xiao H, Li QN, Ren XS, Liu ZG, Hu BW, et al. Epigenetic and post-translational modifications in autophagy: organic features and therapeutic targets. Sign Transduct Goal Ther. 2023;8:32. https://doi.org/10.1038/s41392-022-01300-8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee JM, Hammarén HM, Savitski MM, Baek SH. Management of protein stability by post-translational modifications. Nat Commun. 2023;14:201. https://doi.org/10.1038/s41467-023-35795-8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • DeShields RW. Gnathological issues of a controversial nature. Ohio Dent J. 1977;51:23–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Tolsma TO, Hansen JC. Submit-translational modifications and chromatin dynamics. Essays Biochem. 2019;63:89–96. https://doi.org/10.1042/ebc20180067.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Patwardhan P, Miller WT. Processive phosphorylation: mechanism and organic significance. Cell Sign. 2007;19:2218–26. https://doi.org/10.1016/j.cellsig.2007.06.006.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Galinier A, Deutscher J. Refined regulation of transcriptional components by the bacterial phosphoenolpyruvate: sugar phosphotransferase system. J Mol Biol. 2017;429:773–89. https://doi.org/10.1016/j.jmb.2017.02.006.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Huang B, Zhao Z, Zhao Y, Huang S. Protein arginine phosphorylation in organisms. Int J Biol Macromol. 2021;171:414–22. https://doi.org/10.1016/j.ijbiomac.2021.01.015.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhou T, Wang M, Cheng A, Yang Q, Tian B, Wu Y, et al. Regulation of alphaherpesvirus protein through post-translational phosphorylation. Vet Res. 2022;53:93. https://doi.org/10.1186/s13567-022-01115-z.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Derouiche A, Cousin C, Mijakovic I. Protein phosphorylation from the attitude of methods biology. Curr Opin Biotechnol. 2012;23:585–90. https://doi.org/10.1016/j.copbio.2011.11.008.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gil J, Ramírez-Torres A, Encarnación-Guevara S. Lysine acetylation and most cancers: a proteomics perspective. J Proteom. 2017;150:297–309. https://doi.org/10.1016/j.jprot.2016.10.003.

    Article 
    CAS 

    Google Scholar
     

  • King CM, Glowinski IB. Acetylation, deacetylation and acyltransfer. Environ Well being Perspect. 1983;49:43–50. https://doi.org/10.1289/ehp.834943.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Baeza J, Smallegan MJ, Denu JM. Mechanisms and dynamics of protein acetylation in mitochondria. Development Biochem Sci. 2016;41:231–44. https://doi.org/10.1016/j.tibs.2015.12.006.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kouzarides T. Acetylation: a regulatory modification to rival phosphorylation? Embo j. 2000;19:1176–9. https://doi.org/10.1093/emboj/19.6.1176.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Polevoda B, Sherman F. Methylation of proteins concerned in translation. Mol Microbiol. 2007;65:590–606. https://doi.org/10.1111/j.1365-2958.2007.05831.x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stallcup MR. Function of protein methylation in chromatin reworking and transcriptional regulation. Oncogene. 2001;20:3014–20. https://doi.org/10.1038/sj.onc.1204325.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nicholson TB, Chen T, Richard S. The physiological and pathophysiological position of PRMT1-mediated protein arginine methylation. Pharmacol Res. 2009;60:466–74. https://doi.org/10.1016/j.phrs.2009.07.006.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Eichler J. Protein glycosylation. Curr Biol. 2019;29:R229–31. https://doi.org/10.1016/j.cub.2019.01.003.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rudd PM, Dwek RA. Glycosylation: heterogeneity and the 3D construction of proteins. Crit Rev Biochem Mol Biol. 1997;32:1–100. https://doi.org/10.3109/10409239709085144.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Schjoldager KT, Narimatsu Y, Joshi HJ, Clausen H. World view of human protein glycosylation pathways and features. Nat Rev Mol Cell Biol. 2020;21:729–49. https://doi.org/10.1038/s41580-020-00294-x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xu M, Yang A, Xia J, Jiang J, Liu CF, Ye Z, et al. Protein glycosylation in urine as a biomarker of illnesses. Transl Res. 2023;253:95–107. https://doi.org/10.1016/j.trsl.2022.08.001.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Costa J, Hayes C, Lisacek F. Protein glycosylation and glycoinformatics for novel biomarker discovery in neurodegenerative illnesses. Ageing Res Rev. 2023;89: 101991. https://doi.org/10.1016/j.arr.2023.101991.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xiang T, Zhao S, Wu Y, Li L, Fu P, Ma L. Novel post-translational modifications within the kidneys for human well being and illnesses. Life Sci. 2022;311: 121188. https://doi.org/10.1016/j.lfs.2022.121188.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pienkowski T, Kowalczyk T, Cysewski D, Kretowski A, Ciborowski M. Glioma and post-translational modifications: a posh relationship. Biochim Biophys Acta Rev Most cancers. 2023;1878: 189009. https://doi.org/10.1016/j.bbcan.2023.189009.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hermann J, Schurgers L, Jankowski V. Identification and characterization of post-translational modifications: scientific implications. Mol Asps Med. 2022;86: 101066. https://doi.org/10.1016/j.mam.2022.101066.

    Article 
    CAS 

    Google Scholar
     

  • Jarrold J, Davies CC. PRMTs and arginine methylation: most cancers’s best-kept secret? Development Mol Med. 2019;25:993–1009. https://doi.org/10.1016/j.molmed.2019.05.007.

    Article 
    CAS 

    Google Scholar
     

  • Zhang J, Xun M, Li C, Chen Y. The O-GlcNAcylation and its promotion to hepatocellular carcinoma. Biochim Biophys Acta Rev Most cancers. 2022;1877: 188806. https://doi.org/10.1016/j.bbcan.2022.188806.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hu M, Zhang R, Yang J, Zhao C, Liu W, Huang Y, et al. The position of N-glycosylation modification within the pathogenesis of liver most cancers. Cell Demise Dis. 2023;14:222. https://doi.org/10.1038/s41419-023-05733-z.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Serrano-Gomez SJ, Maziveyi M, Alahari SK. Regulation of epithelial-mesenchymal transition via epigenetic and post-translational modifications. Mol Most cancers. 2016;15:18. https://doi.org/10.1186/s12943-016-0502-x.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu X, Zhang Y, Wang Y, Yang M, Hong F, Yang S. Protein phosphorylation in most cancers: position of nitric oxide signaling pathway. Biomolecules. 2021. https://doi.org/10.3390/biom11071009.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: implications in most cancers and irritation. Development Biochem Sci. 2005;30:43–52. https://doi.org/10.1016/j.tibs.2004.11.009.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ayyadevara S, Balasubramaniam M, Kakraba S, Alla R, Mehta JL, Shmookler Reis RJ. Aspirin-mediated acetylation protects towards a number of neurodegenerative pathologies by impeding protein aggregation. Antioxid Redox Sign. 2017;27:1383–96. https://doi.org/10.1089/ars.2016.6978.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hyun Okay, Jeon J, Park Okay, Kim J. Writing, erasing and studying histone lysine methylations. Exp Mol Med. 2017;49: e324. https://doi.org/10.1038/emm.2017.11.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zheng Okay, Chen S, Ren Z, Wang Y. Protein arginine methylation in viral an infection and antiviral immunity. Int J Biol Sci. 2023;19:5292–318. https://doi.org/10.7150/ijbs.89498.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stowell SR, Ju T, Cummings RD. Protein glycosylation in most cancers. Annu Rev Pathol. 2015;10:473–510. https://doi.org/10.1146/annurev-pathol-012414-040438.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Y, Chen H. Protein glycosylation alterations in hepatocellular carcinoma: operate and scientific implications. Oncogene. 2023;42:1970–9. https://doi.org/10.1038/s41388-023-02702-w.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bangarh R, Khatana C, Kaur S, Sharma A, Kaushal A, Siwal SS, et al. Aberrant protein glycosylation: Implications on analysis and Immunotherapy. Biotechnol Adv. 2023;66: 108149. https://doi.org/10.1016/j.biotechadv.2023.108149.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang YW, Zuo JC, Chen C, Li XH. Submit-translational modifications and immune responses in liver most cancers. Entrance Immunol. 2023;14:1230465. https://doi.org/10.3389/fimmu.2023.1230465.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mowen KA, David M. Unconventional post-translational modifications in immunological signaling. Nat Immunol. 2014;15:512–20. https://doi.org/10.1038/ni.2873.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nagel T, Klaus F, Ibanez IG, Wege H, Lohse A, Meyer B. Quick and facile evaluation of glycosylation and phosphorylation of fibrinogen from human plasma-correlation with liver most cancers and liver cirrhosis. Anal Bioanal Chem. 2018;410:7965–77. https://doi.org/10.1007/s00216-018-1418-7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ren QN, Zhang H, Solar CY, Zhou YF, Yang XF, Lengthy JW, et al. Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis. Hepatology. 2022;75:1123–38. https://doi.org/10.1002/hep.32120.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mestareehi A, Abu-Farsakh N. Affect of protein phosphatase expressions on the prognosis of hepatocellular carcinoma sufferers. ACS Omega. 2024;9:10299–331. https://doi.org/10.1021/acsomega.3c07787.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nishimagi A, Kobayashi M, Sugimoto Okay, Kofunato Y, Sato N, Haga J, et al. Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence. Clin Exp Med. 2023;23:4985–95. https://doi.org/10.1007/s10238-023-01098-x.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang Y, Lao W, Yang Okay, Kong X, Li Y, Yu X, et al. SUV39H1 is a novel biomarker concentrating on oxidative phosphorylation in hepatitis B virus-associated hepatocellular carcinoma. BMC Most cancers. 2023;23:1159. https://doi.org/10.1186/s12885-023-11633-4.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu Okay, Yan M, Liu T, Wang Z, Duan Y, Xia Y, et al. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 via a moonlighting operate. Nat Cell Biol. 2023;25:714–25. https://doi.org/10.1038/s41556-023-01133-9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhan M, Ding Y, Huang S, Liu Y, Xiao J, Yu H, et al. Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to advertise liver most cancers chemoresistance by stabilizing dihydroorotate dehydrogenase. Nat Commun. 2023;14:3123. https://doi.org/10.1038/s41467-023-38753-6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, et al. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. 2020;580:530–5. https://doi.org/10.1038/s41586-020-2183-2.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Feng J, Lu H, Ma W, Tian W, Lu Z, Yang H, et al. Genome-wide CRISPR display identifies artificial lethality between DOCK1 inhibition and metformin in liver most cancers. Protein Cell. 2022;13:825–41. https://doi.org/10.1007/s13238-022-00906-6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wei CY, Zhu MX, Zhang PF, Huang XY, Wan JK, Yao XZ, et al. PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma. J Hepatol. 2022;77:163–76. https://doi.org/10.1016/j.jhep.2022.02.019.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jiang N, Li W, Jiang S, Xie M, Liu R. Acetylation in pathogenesis: revealing rising mechanisms and therapeutic prospects. Biomed Pharmacother. 2023;167: 115519. https://doi.org/10.1016/j.biopha.2023.115519.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wu Z, Guan KL. Acetyl-CoA, protein acetylation, and liver most cancers. Mol Cell. 2022;82:4196–8. https://doi.org/10.1016/j.molcel.2022.10.015.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang LT, Wang SN, Chiou SS, Liu KY, Chai CY, Chiang CM, et al. TIP60-dependent acetylation of the SPZ1-TWIST advanced promotes epithelial-mesenchymal transition and metastasis in liver most cancers. Oncogene. 2019;38:518–32. https://doi.org/10.1038/s41388-018-0457-z.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jing Z, Gao J, Li J, Niu F, Tian L, Nan P, et al. Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver most cancers to systemic remedy. Most cancers Lett. 2021;519:46–62. https://doi.org/10.1016/j.canlet.2021.06.016.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gu L, Zhu Y, Lin X, Tan X, Lu B, Li Y. Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis. Oncogene. 2020;39:2437–49. https://doi.org/10.1038/s41388-020-1156-0.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lin M, He J, Zhang X, Solar X, Dong W, Zhang R, et al. Concentrating on fibrinogen-like protein 1 enhances immunotherapy in hepatocellular carcinoma. J Clin Make investments. 2023. https://doi.org/10.1172/jci164528.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hu H, Zhu W, Qin J, Chen M, Gong L, Li L, et al. Acetylation of PGK1 promotes liver most cancers cell proliferation and tumorigenesis. Hepatology. 2017;65:515–28. https://doi.org/10.1002/hep.28887.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang T, Cui Y, Wu Y, Meng J, Han L, Zhang J, et al. Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma. Clin Transl Med. 2022;12: e852. https://doi.org/10.1002/ctm2.852.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou Y, Jia Okay, Wang S, Li Z, Li Y, Lu S, et al. Malignant development of liver most cancers progenitors requires lysine acetyltransferase 7-acetylated and cytoplasm-translocated G protein GαS. Hepatology. 2023;77:1106–21. https://doi.org/10.1002/hep.32487.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bi L, Ren Y, Feng M, Meng P, Wang Q, Chen W, et al. HDAC11 regulates glycolysis via the LKB1/AMPK signaling pathway to keep up hepatocellular carcinoma stemness. Most cancers Res. 2021;81:2015–28. https://doi.org/10.1158/0008-5472.Can-20-3044.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Cai LY, Chen SJ, Xiao SH, Solar QJ, Ding CH, Zheng BN, et al. Concentrating on p300/CBP attenuates hepatocellular carcinoma development via epigenetic regulation of metabolism. Most cancers Res. 2021;81:860–72. https://doi.org/10.1158/0008-5472.Can-20-1323.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xia H, Hui KM. Emergence of aspirin as a promising chemopreventive and chemotherapeutic agent for liver most cancers. Cell Demise Dis. 2017;8: e3112. https://doi.org/10.1038/cddis.2017.513.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nio Okay, Yamashita T, Kaneko S. The evolving idea of liver most cancers stem cells. Mol Most cancers. 2017;16:4. https://doi.org/10.1186/s12943-016-0572-9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cheng Z, Li X, Ding J. Traits of liver most cancers stem cells and scientific correlations. Most cancers Lett. 2016;379:230–8. https://doi.org/10.1016/j.canlet.2015.07.041.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xue M, Dong L, Zhang H, Li Y, Qiu Okay, Zhao Z, et al. METTL16 promotes liver most cancers stem cell self-renewal through controlling ribosome biogenesis and mRNA translation. J Hematol Oncol. 2024;17:7. https://doi.org/10.1186/s13045-024-01526-9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Solar JH, Luo Q, Liu LL, Music GB. Liver most cancers stem cell markers: development and therapeutic implications. World J Gastroenterol. 2016;22:3547–57. https://doi.org/10.3748/wjg.v22.i13.3547.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang F, Gao Y, Xue S, Zhao L, Jiang H, Zhang T, et al. SCARB2 drives hepatocellular carcinoma tumor initiating cells through enhanced MYC transcriptional exercise. Nat Commun. 2023;14:5917. https://doi.org/10.1038/s41467-023-41593-z.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Raposo AE, Piller SC. Protein arginine methylation: an rising regulator of the cell cycle. Cell Div. 2018;13:3. https://doi.org/10.1186/s13008-018-0036-2.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao J, Adams A, Roberts B, O’Neil M, Vittal A, Schmitt T, et al. Protein arginine methyl transferase 1- and Jumonji C domain-containing protein 6-dependent arginine methylation regulate hepatocyte nuclear issue 4 alpha expression and hepatocyte proliferation in mice. Hepatology. 2018;67:1109–26. https://doi.org/10.1002/hep.29587.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lei Y, Han P, Chen Y, Wang H, Wang S, Wang M, et al. Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma progress by enhancing arginine methylation of lactate dehydrogenase A. Clin Transl Med. 2022;12: e686. https://doi.org/10.1002/ctm2.686.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shi Y, Niu Y, Yuan Y, Li Okay, Zhong C, Qiu Z, et al. PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver most cancers. Nat Commun. 2023;14:1932. https://doi.org/10.1038/s41467-023-37542-5.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li Q, Zhang L, Yang Q, Li M, Pan X, Xu J, et al. Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and-independent manners. Cell Metab. 2023;35:912-27.e7. https://doi.org/10.1016/j.cmet.2023.03.017.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang Okay, Luo L, Fu S, Wang M, Wang Z, Dong L, et al. PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. Nat Commun. 2023;14:1011. https://doi.org/10.1038/s41467-023-36708-5.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Deng W, Ai J, Zhang W, Zhou Z, Li M, Yan L, et al. Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to speed up hepatitis B virus-associated hepatocellular carcinoma development. J Transl Med. 2023;21:625. https://doi.org/10.1186/s12967-023-04408-9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Thng DKH, Hooi L, Toh CCM, Lim JJ, Rajagopalan D, Syariff IQC, et al. Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver most cancers. Mol Oncol. 2023;17:2275–94. https://doi.org/10.1002/1878-0261.13417.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu Z, Wang Q, Mao J, Wang Okay, Fang Z, Miao QR, et al. Comparative proteomic evaluation of protein methylation supplies perception into the resistance of hepatocellular carcinoma to 5-fluorouracil. J Proteom. 2020;219: 103738. https://doi.org/10.1016/j.jprot.2020.103738.

    Article 
    CAS 

    Google Scholar
     

  • Liu Q, Chen Okay, Liu Z, Huang Y, Zhao R, Wei L, et al. BORIS up-regulates OCT4 through histone methylation to advertise most cancers stem cell-like properties in human liver most cancers cells. Most cancers Lett. 2017;403:165–74. https://doi.org/10.1016/j.canlet.2017.06.017.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Guo M, Yao Z, Jiang C, Songyang Z, Gan L, Xiong Y. Three-dimensional and single-cell sequencing of liver most cancers reveals complete host-virus interactions in HBV an infection. Entrance Immunol. 2023;14:1161522. https://doi.org/10.3389/fimmu.2023.1161522.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • You H, Zhang N, Yu T, Ma L, Li Q, Wang X, et al. Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 through TRIM25 to facilitate hepatocarcinogenesis. Br J Most cancers. 2023;128:992–1004. https://doi.org/10.1038/s41416-022-02115-8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Y, Zhao M, Zhao L, Geng Y, Li G, Chen L, et al. HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to assist liver most cancers development. Most cancers Res. 2023;83:1048–61. https://doi.org/10.1158/0008-5472.Can-22-3169.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang L, Zou T, Chen Y, Zhao Y, Wu X, Li M, et al. Hepatitis B virus X protein mediated epigenetic alterations within the pathogenesis of hepatocellular carcinoma. Hepatol Int. 2022;16:741–54. https://doi.org/10.1007/s12072-022-10351-6.

    Article 
    PubMed 

    Google Scholar
     

  • Liu S, Koh SS, Lee CG. Hepatitis B virus X protein and hepatocarcinogenesis. Int J Mol Sci. 2016. https://doi.org/10.3390/ijms17060940.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen J, Li X, Ge C, Min J, Wang F. The multifaceted position of ferroptosis in liver illness. Cell Demise Differ. 2022;29:467–80. https://doi.org/10.1038/s41418-022-00941-0.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang W, Lu Okay, Jiang X, Wei Q, Zhu L, Wang X, et al. Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in major liver most cancers. J Exp Clin Most cancers Res. 2023;42:142. https://doi.org/10.1186/s13046-023-02720-2.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Huang Y, Wang S, Ke A, Guo Okay. Ferroptosis and its interplay with tumor immune microenvironment in liver most cancers. Biochim Biophys Acta Rev Most cancers. 2023;1878: 188848. https://doi.org/10.1016/j.bbcan.2022.188848.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang L, Tian S, Zheng X, Zhang M, Zhou X, Shang Y, et al. N6-methyladenosine RNA methylation in liver illnesses: from mechanism to remedy. J Gastroenterol. 2023;58:718–33. https://doi.org/10.1007/s00535-023-02008-4.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu Y, Feng W, Wang Y, Wu B. Crosstalk between protein post-translational modifications and section separation. Cell Commun Sign. 2024;22:110. https://doi.org/10.1186/s12964-023-01380-1.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Im H, Baek HJ, Yang E, Kim Okay, Oh SK, Lee JS, et al. ROS inhibits RORα degradation by reducing its arginine methylation in liver most cancers. Most cancers Sci. 2023;114:187–200. https://doi.org/10.1111/cas.15595.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Blomme B, Van Steenkiste C, Callewaert N, Van Vlierberghe H. Alteration of protein glycosylation in liver illnesses. J Hepatol. 2009;50:592–603. https://doi.org/10.1016/j.jhep.2008.12.010.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang X, Liu H, Wang H, Zhao R, Lu Q, Liu Y, et al. B3galt5 deficiency attenuates hepatocellular carcinoma by suppressing mTOR/p70s6k-mediated glycolysis. Cell Mol Life Sci. 2022;80:8. https://doi.org/10.1007/s00018-022-04601-x.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cheng H, Wang S, Gao D, Yu Okay, Chen H, Huang Y, et al. Nucleotide sugar transporter SLC35A2 is concerned in selling hepatocellular carcinoma metastasis by regulating mobile glycosylation. Cell Oncol. 2023;46:283–97. https://doi.org/10.1007/s13402-022-00749-7.

    Article 
    CAS 

    Google Scholar
     

  • Nguyen AT, Chia J, Ros M, Hui KM, Saltel F, Bard F. Organelle particular O-glycosylation drives MMP14 activation, tumor progress, and metastasis. Most cancers Cell. 2017;32:639-53.e6. https://doi.org/10.1016/j.ccell.2017.10.001.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li J, Liu X, Peng B, Feng T, Zhou W, Meng L, et al. O-GlcNAc has crosstalk with ADP-ribosylation through PARG. J Biol Chem. 2023;299: 105354. https://doi.org/10.1016/j.jbc.2023.105354.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou P, Chang WY, Gong DA, Xia J, Chen W, Huang LY, et al. Excessive dietary fructose promotes hepatocellular carcinoma development by enhancing O-GlcNAcylation through microbiota-derived acetate. Cell Metab. 2023;35:1961-75.e6. https://doi.org/10.1016/j.cmet.2023.09.009.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xiang J, Chen C, Liu R, Gou D, Chang L, Deng H, et al. Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma progress upon glucose deprivation. J Clin Make investments. 2021. https://doi.org/10.1172/jci144703.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zou X, Lu J, Deng Y, Liu Q, Yan X, Cui Y, et al. ST6GAL1 inhibits metastasis of hepatocellular carcinoma through modulating sialylation of MCAM on cell floor. Oncogene. 2023;42:516–29. https://doi.org/10.1038/s41388-022-02571-9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu L, Pan Y, Zhao C, Huang P, Chen X, Rao L. Boosting checkpoint immunotherapy with biomaterials. ACS Nano. 2023;17:3225–58. https://doi.org/10.1021/acsnano.2c11691.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Khalilov R, Bakishzade A, Nasibova A. Future prospects of biomaterials in nanomedicine. Adv Biol Earth Sci. 2023. https://doi.org/10.62476/abes.9s5.

    Article 

    Google Scholar
     

  • Rosic G, Selakovic D, Omarova S. Most cancers signaling, cell/gene remedy, analysis and position of nanobiomaterials. Adv Biol Earth Sci. 2024. https://doi.org/10.62476/abes9s11.

    Article 

    Google Scholar
     

  • Huseynov E, Khalilov R, Mohamed AJ. Novel nanomaterials for hepatobiliary illnesses remedy and future views. Adv Biol Earth Sci. 2024. https://doi.org/10.2476/abes9s81.

    Article 

    Google Scholar
     

  • Salahshour P. Nanobiomaterials/bioinks based mostly scaffolds in 3d bioprinting for tissue engineering and synthetic human organs. Adv Biol Earth Sci. 2024;9:97–104. https://doi.org/10.2476/abes9s97.

    Article 

    Google Scholar
     

  • Erdil N. Heart problems, signaling, gene/cell remedy and superior nanobiomaterials. Adv Biol Earth Sci. 2024;9:58–80.

    Article 

    Google Scholar
     

  • Xu M, Yang L, Lin Y, Lu Y, Bi X, Jiang T, et al. Rising nanobiotechnology for exact theranostics of hepatocellular carcinoma. J Nanobiotechnology. 2022;20:427. https://doi.org/10.1186/s12951-022-01615-2.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chi X, Liu Okay, Luo X, Yin Z, Lin H, Gao J. Current advances of nanomedicines for liver most cancers remedy. J Mater Chem B. 2020;8:3747–71. https://doi.org/10.1039/c9tb02871d.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shao D, Li J, Zheng X, Pan Y, Wang Z, Zhang M, et al. Janus “nano-bullets” for magnetic concentrating on liver most cancers chemotherapy. Biomaterials. 2016;100:118–33. https://doi.org/10.1016/j.biomaterials.2016.05.030.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Han Q, Du L, Zhu L, Yu D. Assessment of the applying of twin drug supply nanotheranostic brokers within the analysis and remedy of liver most cancers. Molecules. 2023. https://doi.org/10.3390/molecules28207004.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu S, Fan Okay, Yang Q, Chen Z, Hou Y, Zou Y, et al. Sensible nanoparticles and microbeads for interventional embolization remedy of liver most cancers: cutting-edge. J Nanobiotechnology. 2023;21:42. https://doi.org/10.1186/s12951-023-01804-7.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kong FH, Ye QF, Miao XY, Liu X, Huang SQ, Xiong L, et al. Present standing of sorafenib nanoparticle supply methods within the remedy of hepatocellular carcinoma. Theranostics. 2021;11:5464–90. https://doi.org/10.7150/thno.54822.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hot Topics

    Related Articles