Listed below are 5 high tales that had been coated throughout the 2024 San Antonio Breast Most cancers Symposium.
Research outcomes offered at this month’s San Antonio Breast Most cancers Symposium highlighted a number of advances within the remedy of breast most cancers.
CURE® chosen a few of the high tales from our protection of the breast most cancers assembly, which included matters equivalent to superior breast most cancers, unwanted effects in older sufferers, circulating tumor DNA (ctDNA) detection and extra.
Time to Subsequent Therapy Barely Larger With Orserdu in Breast Most cancers Subset
Glossary
Development-free survival: time throughout which a affected person’s illness doesn’t worsen.
Actual-world time to subsequent remedy: time from beginning remedy to beginning the following remedy.
Actual-world time to remedy discontinuation: time from beginning remedy to stopping it for any purpose.
Circulating tumor DNA: traces of most cancers cells remaining within the bloodstream.
Neoadjuvant: remedy given earlier than surgical procedure.
Residual most cancers burden rating: a system that estimates how a lot most cancers can be left within the physique after neoadjuvant remedy. A rating of zero means there’s no residual most cancers, whereas a rating of three means there’s an intensive quantity of residual most cancers.
QLQ-C30 GHS rating: a rating measuring a affected person’s high quality of life, with larger scores representing the next high quality of life.
G8 rating: a screening device used to judge older sufferers.
A real-world evaluation discovered that Orserdu (elacestrant) yielded comparable or barely higher time to remedy discontinuation and time to subsequent remedy than the progression-free survival (PFS) reported within the part 3 EMERALD trial for sufferers with HR-positive/HER2-negative superior breast most cancers and ESR1 mutations.
An evaluation of 742 sufferers receiving Orserdu (imply age, 63 years) confirmed a median real-world time to subsequent remedy (rwTTNT) of 6.43 months and a median real-world time to remedy discontinuation (rwTTD) of 4.6 months.
Though most sufferers acquired Orserdu within the third or fourth line of remedy, the remedy line didn’t considerably have an effect on outcomes. Median rwTTNT ranged from 5.9 to eight.8 months, and median rwTTD ranged from 4.5 to five.3 months throughout the second, third and fourth traces.
Older Sufferers With Early Breast Most cancers Might Have Worse Immune Aspect Results
Researchers offered findings from a multi-institutional examine suggesting a possible hyperlink between prior immune checkpoint inhibitor use in early-stage breast most cancers and an elevated threat of high-grade immune-related unwanted effects in older sufferers.
In sufferers with early-stage breast most cancers handled with immune checkpoint inhibitors, 72.6% skilled any-grade immune-related unwanted effects, and 18.9% skilled high-grade results. Whereas the bulk (81%) skilled no high-grade occasions, 17% skilled one and 1.7% skilled two. No sufferers skilled greater than two high-grade unwanted effects. The distribution of any-grade occasions was as follows: none (27%), one (43%), two (23%), three (5.7%), 4 (1.2%) and 5 (0.2%).
Extremely-Delicate Testing Can Detect ctDNA in HR-Constructive Breast Most cancers
Findings from a part 2 trial demonstrated ctDNA detection utilizing an ultra-sensitive tissue-free methodology in sufferers with HR-positive early breast most cancers.
Baseline ctDNA was related to bigger pathological tumor dimension and better residual most cancers burden scores after neoadjuvant endocrine remedy. Dr. Albert Grinshpun and colleagues additionally reported that detectable ctDNA after remedy correlated with larger recurrence charges.
Within the part 2 PELOPS trial, 49 sufferers with stage 1 to three HR-positive, HER2-negative breast most cancers had been randomly assigned to obtain both neoadjuvant endocrine remedy together with Ibrance (palbociclib; 35 sufferers) or neoadjuvant endocrine remedy alone (13 sufferers).
Postoperative Radiation Affords Larger High quality of Life, Fewer Aspect Results in Some with Breast Most cancers
Research outcomes from the part 3 EUROPA trial demonstrated that, at 24 months, older sufferers with stage 1 luminal-like breast most cancers had higher health-related high quality of life (HRQOL) and fewer treatment-related unwanted effects with postoperative radiation remedy than with unique endocrine remedy.
Relating to HRQOL, the radiation remedy group skilled a smaller decline from baseline to 24 months in comparison with the endocrine remedy group. The imply change from baseline was -1.1 versus -10, respectively. After adjusting for age and G8 rating, the median change was -3.4 versus -9.79, respectively. Baseline median scores had been 71.9 (radiation remedy) and 75.5 (endocrine remedy).
Enhertu Improves Development-Free Survival in HR-Constructive, HER2-Low/Ultralow Metastatic Breast Most cancers
Enhertu (fam-trastuzumab deruxtecan-nxki) improved PFS in comparison with doctor’s alternative (TPC) in sufferers with HR-positive, HER2-low/-ultralow metastatic breast most cancers, no matter time to development (TTP) on frontline endocrine remedy with CDK4/6 inhibition or the kind of endocrine resistance, in line with outcomes from the DESTINY-Breast06 trial.
Median PFS with Enhertu was 14 months versus 6.5 months with TPC for sufferers with TTP lower than 6 months, 13.2 months versus 6.9 months for TTP between 6 and12 months and 12.9 months versus 8.2 months for TTP higher than 12 months.
In sufferers with major endocrine resistance, median PFS was 12.4 months with Enhertu versus 6.6 months with TPC. For these with secondary endocrine resistance, median PFS was 13.2 months with Enhertu versus 9.5 months with TPC.
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