Given Months to Stay, She’s Now a 5-Yr Glioblastoma Survivor

Kyle Donahue, who was given months to stay after receiving a prognosis of glioblastoma in 2021, enrolled in a medical trial at Brigham and Girls’s Hospital in Massachusetts, and is now a five-year survivor of mind most cancers.

CURE sat down for interviews with Kyle Donahue and her husband, Jim, in addition to Dr. E. Antonio Chiocca, Chair of Brigham’s Division of Neurosurgery and lead researcher on the medical trial.

In a information launch issued in in October 2025, Candel Therapeutics, Inc., a clinical-stage biopharmaceutical firm, detailed interim knowledge from the continuing part 1b medical trial of CAN-3110 (linoserpaturev) in recurrent glioblastoma, which was additionally revealed within the journal Science Translational Drugs.

Within the second installment of a multi-part sequence, CURE spoke with Kyle Donahue to debate the medical trial that she enrolled in.

Transcript

Are you able to stroll us via your expertise collaborating within the CAN-3110 medical trial, together with what the remedy course of was like and the way it impacted you?

After I agreed to the medical trial, and it was my flip, we mentioned it, however the week is basically troublesome, as it’s possible you’ll know. With the Candel drug that I acquired, the primary day, you go in, have an MRI, that was Monday. The second day you have got the chemo. And I had at all times simply taken chemo capsules, and this was a chemo infusion for about seven hours, that was Tuesday. Then they provide you Wednesday off so you possibly can really feel sick all day lengthy. And you then return in for Thursday, and that is when you have got the surgical procedure. So I used to be totally conscious of what was taking place, however the Candel medicine, CAN-3110, it saved my life. It actually did, as a result of I believe it goes in first, and so they described it as like a Pac-Man that goes in and eats all of the most cancers cells, and what it is attempting to do is prepare your immune system to acknowledge them. And I am completely satisfied for each single additional day that I I’ve gotten from this, as a result of clearly it did prepare my immune system.

Transcript has been edited for readability and conciseness.

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