Food regimen adjustments attributable to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal most cancers


  • Sung, H. et al. International Most cancers Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 nations. CA Most cancers J. Clin. 71, 209–249 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • O’Keefe, S. J. The affiliation between dietary fibre deficiency and high-income lifestyle-associated illnesses: Burkitt’s speculation revisited. Lancet Gastroenterol. Hepatol. 4, 984–996 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aune, D. et al. Dietary fibre, entire grains, and danger of colorectal most cancers: systematic evaluate and dose-response meta-analysis of potential research. Br. Med. J. 343, d6617 (2011).

    Article 

    Google Scholar
     

  • Reynolds, A. et al. Carbohydrate high quality and human well being: a sequence of systematic evaluations and meta-analyses. Lancet 393, 434–445 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang, L. et al. Affiliation of ultra-processed meals consumption with colorectal most cancers danger amongst women and men: outcomes from three potential US cohort research. Br. Med. J. 378, e068921 (2022).

    Article 

    Google Scholar
     

  • O’Keefe, S. J. D. Food regimen, microorganisms and their metabolites, and colon most cancers. Nat. Rev. Gastroenterol. Hepatol. 13, 691–706 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Donohoe, D. R. et al. A gnotobiotic mouse mannequin demonstrates that dietary fiber protects in opposition to colorectal tumorigenesis in a microbiota- and butyrate-dependent method. Most cancers Discov. 4, 1387–1397 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ocvirk, S. & O’Keefe, S. J. D. Dietary fats, bile acid metabolism and colorectal most cancers. Semin. Most cancers Biol. 73, 347–355 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Waddell, I. S. & Orfila, C. Dietary fiber within the prevention of weight problems and obesity-related persistent illnesses: from epidemiological proof to potential molecular mechanisms. Crit. Rev. Meals Sci. Nutr. 63, 8752–8767 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Roomaney, R. A., van Wyk, B., Cois, A. & Pillay-van Wyk, V. Inequity within the distribution of non-communicable illness multimorbidity in adults in South Africa: an evaluation of prevalence and patterns. Int. J. Public Well being 67, 1605072 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pillay-van Wyk, V. et al. Mortality traits and differentials in South Africa from 1997 to 2012: second Nationwide Burden of Illness Examine. Lancet Glob. Well being 4, e642–e653 (2016).

    Article 
    PubMed 

    Google Scholar
     

  • Vorster, H. H., Kruger, A., Wentzel-Viljoen, E., Kruger, H. S. & Margetts, B. M. Added sugar consumption in South Africa: findings from the Grownup Potential City and Rural Epidemiology cohort research. Am. J. Clin. Nutr. 99, 1479–1486 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rogerson, J. M., Kotze, N. & Rogerson, C. M. Addressing South Africa’s city challenges. City. Izziv 25, S1–S4 (2014).

    Article 

    Google Scholar
     

  • Bigna, J. J. & Noubiap, J. J. The rising burden of non-communicable illnesses in sub-Saharan Africa. Lancet Glob. Well being 7, 1295 (2019).

    Article 

    Google Scholar
     

  • Nugent, R. et al. Investing in non-communicable illness prevention and administration to advance the sustainable growth objectives. Lancet 391, 2029–2035 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Angelakis, E. et al. Comparability of the intestine microbiota of overweight people from completely different geographic origins. N. Microbes N. Infect. 27, 40–47 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Mann, N. et al. The impact of eating regimen on plasma homocysteine concentrations in wholesome male topics. Eur. J. Clin. Nutr. 53, 895–899 (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Metwaly, A. et al. Built-in microbiota and metabolite profiles hyperlink Crohn’s illness to sulfur metabolism. Nat. Commun. 11, 4322 (2020).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Halpern, M., Fridman, S., Atamna-Ismaeel, N. & Izhaki, I. Rosenbergiella nectarea gen. nov., sp. nov., within the household Enterobacteriaceae, remoted from floral nectar. Int. J. Syst. Evol. Microbiol. 63, 4259–4265 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Teixeira, C. G. et al. Weissella: an rising bacterium with promising well being advantages. Probiotics Antimicrob. Proteins 13, 915–925 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Misner, B. D. Animal proteins affect blood lipids and homocysteine. Br. Med. J. 330, 111 (2005).


    Google Scholar
     

  • Chompre, G. et al. A one month excessive fats eating regimen disrupts the intestine microbiome and integrity of the colon inducing adiposity and behavioral despair in male Sprague Dawley rats. Heliyon 8, e11194 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Singh, R. P., Halaka, D. A., Hayouka, Z. & Tirosh, O. Excessive-fat eating regimen induced alteration of mice microbiota and the purposeful skill to make the most of fructooligosaccharide for ethanol manufacturing. Entrance. Cell. Infect. Microbiol. 10, 376 (2020).

  • Nakayama, J. et al. Impression of Westernized eating regimen on intestine microbiota in youngsters on Leyte island. Entrance. Microbiol. 8, 197 (2017).

  • Martinez-Medina, M. et al. Western eating regimen induces dysbiosis with elevated E coli in CEABAC10 mice, alters host barrier perform favouring AIEC colonisation. Intestine 63, 116–124 (2014).

    Article 
    PubMed 

    Google Scholar
     

  • Shkoporov, A. N. et al. Lengthy-term persistence of crAss-like phage crAss001 is related to section variation in Bacteroides intestinalis. BMC Biol. 19, 163 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Castellarin, M. et al. Fusobacterium nucleatum an infection is prevalent in human colorectal carcinoma. Genome Res. 22, 299–306 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kostic, A. D. et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 14, 207–215 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shen, S., Huo, D., Ma, C., Jiang, S. & Zhang, J. Increasing the colorectal most cancers biomarkers primarily based on the human intestine phageome. Microbiol. Spectr. 9, e00090–21 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Moschen, A. R. et al. Lipocalin 2 protects from irritation and tumorigenesis related to intestine microbiota alterations. Cell Host Microbe 19, 455–469 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang, J. et al. Excessive-fat eating regimen promotes colorectal tumorigenesis by modulating intestine microbiota and metabolites. Gastroenterology 162, 135–149.e2 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ocvirk, S. et al. A potential cohort evaluation of intestine microbial co-metabolism in Alaska Native and rural African individuals at excessive and low danger of colorectal most cancers. Am. J. Clin. Nutr. 111, 406–419 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Devkota, S. et al. Dietary-fat-induced taurocholic acid promotes pathobiont enlargement and colitis in Il10-/- mice. Nature 487, 104–108 (2012).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kieft, Okay. et al. Ecology of inorganic sulfur auxiliary metabolism in widespread bacteriophages. Nat. Commun. 12, 3503 (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cornuault, J. Okay. et al. Phages infecting Faecalibacterium prausnitzii belong to novel viral genera that assist to decipher intestinal viromes. Microbiome 6, 65 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • O’Keefe, S. J. D. et al. Fats, fibre and most cancers danger in African People and Rural Africans. Nat. Commun. 6, 6342 (2015).

    Article 
    ADS 
    PubMed 

    Google Scholar
     

  • Weir, T. L. et al. Stool microbiome and metabolome variations between colorectal most cancers sufferers and wholesome adults. PLoS ONE 8, e70803 (2013).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wirbel, J. et al. Meta-analysis of fecal metagenomes reveals world microbial signatures which are particular for colorectal most cancers. Nat. Med. 25, 679–689 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Katsidzira, L. et al. Variations in fecal intestine microbiota, short-chain fatty acids and bile acids hyperlink colorectal most cancers danger to dietary adjustments related to urbanization amongst zimbabweans. Nutr. Most cancers 71, 1313–1324 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Campbell, D. E. et al. An infection with bacteroides phage BV01 alters the host transcriptome and bile acid metabolism in a standard human intestine microbe. Cell Rep. 32, 108142 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Boling, L. et al. Dietary prophage inducers and antimicrobials: towards landscaping the human intestine microbiome. Intestine Microbes 11, 721–734 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Borodovich, T., Shkoporov, A. N., Ross, R. P. & Hill, C. Phage-mediated horizontal gene switch and its implications for the human intestine microbiome. Gastroenterol. Rep. 10, goac012 (2022).

    Article 

    Google Scholar
     

  • McCall, L.-I. et al. Dwelling chemical and microbial transitions throughout urbanization. Nat. Microbiol. 5, 108–115 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Obuya, S. et al. A signature of Prevotella copri and Faecalibacterium prausnitzii depletion, and a hyperlink with bacterial glutamate degradation within the Kenyan colorectal most cancers sufferers. J. Gastrointest. Oncol. 13, 2282–2292 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • de Goffau, M. C. et al. Intestine microbiomes from Gambian infants reveal the event of a non-industrialized Prevotella-based trophic community. Nat. Microbiol 7, 132–144 (2022).

    Article 
    PubMed 

    Google Scholar
     

  • Oduaran, O. H. et al. Intestine microbiome profiling of a rural and concrete South African cohort reveals biomarkers of a inhabitants in way of life transition. BMC Microbiol. 20, 330 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ou, J. et al. Food regimen, microbiota, and microbial metabolites in colon most cancers danger in rural Africans and African People. Am. J. Clin. Nutr. 98, 111–120 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sonnenburg, E. D. et al. Food regimen-induced extinctions within the intestine microbiota compound over generations. Nature 529, 212–215 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gellman, R. H. et al. Hadza prevotella require diet-derived microbiota accessible carbohydrates to persist in mice. bioRxiv https://doi.org/10.1101/2023.03.08.531063 (2023).

  • Tamburini, F. B. et al. Quick- and long-read metagenomics of city and rural South African intestine microbiomes reveal a transitional composition and undescribed taxa. Nat. Commun. 13, 926 (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mancabelli, L. et al. Meta-analysis of the human intestine microbiome from urbanized and pre-agricultural populations. Environ. Microbiol. 19, 1379–1390 (2017).

    Article 
    PubMed 

    Google Scholar
     

  • Gurry, T., Nguyen, L. T. T., Yu, X. & Alm, E. J. Practical heterogeneity within the fermentation capabilities of the wholesome human intestine microbiota. PLoS ONE 16, e0254004 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Veronese, N. et al. Dietary fiber and well being outcomes: an umbrella evaluate of systematic evaluations and meta-analyses. Am. J. Clin. Nutr. 107, 436–444 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Paulo, L. S. et al. Urbanization gradient, eating regimen, and intestine microbiota in Sub-Saharan Africa: a scientific evaluate. Entrance. Microbiomes 2, 1208166 (2023).

  • Dalal, S. et al. Non-communicable illnesses in sub-Saharan Africa: what we all know now. Int. J. Epidemiol. 40, 885–901 (2011).

    Article 
    PubMed 

    Google Scholar
     

  • Wentzel-Viljoen, E., Laubscher, R. & Kruger, A. Utilizing completely different approaches to evaluate the reproducibility of a culturally delicate quantified meals frequency questionnaire. South Afr. J. Clin. Nutr. 24, 143–148 (2011).

    Article 

    Google Scholar
     

  • SAFOODS. SAMRC Meals Portions Guide for South Africa. (South African Medical Analysis Council, 2018).

  • SAFOODS. SAMRC Meals Composition Tables for South Africa. (South African Medical Analysis Council, 2017).

  • Eberhart, B. L., Wilson, A. S., O’Keefe, S. J. D., Ramaboli, M. C. & Nesengani, L. T. A simplified technique for the quantitation of short-chain fatty acids in human stool. Anal. Biochem. 612, 114016 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zheng, J., Johnson, M., Mandal, R. & Wishart, D. S. A complete focused metabolomics assay for crop plant pattern evaluation. Metabolites 11, 303 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Reitmeier, S., Kiessling, S., Neuhaus, Okay. & Haller, D. Evaluating circadian rhythmicity within the human intestine microbiome. STAR Protoc. 1, 100148 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lagkouvardos, I. et al. IMNGS: a complete open useful resource of processed 16S rRNA microbial profiles for ecology and variety research. Sci. Rep. 6, 33721 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Khan Mirzaei, M. et al. Bacteriophages remoted from stunted youngsters can regulate intestine bacterial communities in an age-specific method. Cell Host Microbe 27, 199–212 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ru, J., Khan Mirzaei, M., Xue, J., Peng, X. & Deng, L. ViroProfiler: a containerized bioinformatics pipeline for viral metagenomic information evaluation. Intestine Microbes 15, 2192522 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lagkouvardos, I., Fischer, S., Kumar, N. & Clavel, T. Rhea: a clear and modular R pipeline for microbial profiling primarily based on 16S rRNA gene amplicons. PeerJ 5, e2836 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dietrich, A. et al. Namco: a microbiome explorer. Microb. Genom. 8, mgen000852 (2022).

    PubMed 
    PubMed Central 

    Google Scholar
     

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