PHILADELPHIA, PA — Context Therapeutics Inc. (Nasdaq: CNTX) introduced a big addition to its drug pipeline with the acquisition of CT-95 from Hyperlink Immunotherapeutics, Inc. The asset is a mesothelin (MSLN) x CD3 T cell-engaging (TCE) bispecific antibody. Any such antibody has proven potential to be a first-in-class most cancers therapy. The U.S. Meals and Drug Administration has already cleared CT-95 for Investigational New Drug (IND) standing, setting the stage for Section 1 scientific trials to start in early 2025.
“We’re thrilled so as to add CT-95, previously often known as LNK101, to our pipeline,” mentioned Martin Lehr, CEO of Context Therapeutics. “The acquisition aligns completely with our purpose of creating TCE belongings to deal with strong tumors. MSLN is very prevalent in cancers equivalent to ovarian, lung, and pancreatic.”
Bispecific antibodies like CT-95 are designed to interact two totally different targets concurrently. This specific antibody targets MSLN on most cancers cells and CD3 on T cells. By bringing these two elements collectively, CT-95 goals to direct the physique’s immune system to assault the most cancers cells extra successfully. Preclinical research have proven promising outcomes, suggesting that CT-95 could possibly be each a first-in-class and best-in-class therapy.
CT-95’s give attention to MSLN is especially related as a result of this protein is overexpressed in a number of varieties of aggressive cancers. These embrace ovarian, lung, and pancreatic cancers, which frequently have restricted therapy choices and poor prognoses. Due to this fact, a profitable remedy concentrating on MSLN might tackle a big unmet medical want.
“CT-95 is an IND-cleared asset that we plan to quickly progress into scientific trials,” Mr. Lehr added. “We intend to fund the acquisition and its development by way of the dose escalation portion of a Section 1 scientific trial with Context’s present money.”
The forthcoming Section 1 trials will intention to determine the suitable dosage and consider the protection of CT-95. Ought to these trials succeed, the therapy might transfer rapidly into later levels of scientific testing, doubtlessly providing new hope for sufferers battling hard-to-treat cancers.
This acquisition not solely strengthens Context Therapeutics’ pipeline but in addition highlights the corporate’s dedication to advancing revolutionary most cancers remedies. Because the biotech trade continues to evolve, pioneering therapies like CT-95 might redefine how we strategy most cancers therapy, making this a growth price watching carefully.
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