It’s vital for sufferers with renal clear cell (RCC) carcinoma — a typical sort of kidney most cancers — to think about the challenges related to receiving Fotivda (tivozanib).
Fotivda is a vascular endothelial development issue (VEGF) tyrosine kinase inhibitor (TKI) to deal with sufferers with renal clear cell carcinoma. Eligible sufferers skilled most cancers relapse (returned) and had not improved after at the least two earlier strains of systemic remedy, in line with the Nationwide Most cancers Institute.
The Meals and Drug Administration authorised Fotivda for this affected person inhabitants in March 2021.
Frequent unwanted side effects related to the remedy of Fotivda alone embody hypertension (hypertension) and diarrhea. Nonetheless, as a result of the drug has been round for a number of years, care groups are extra outfitted to assist sufferers handle VEGF TKI-related unwanted side effects, Dr. Toni Ok. Choueiri defined to CURE® on the 2024 ESMO Congress.
Choueiri is a medical oncologist and director of the Lank Middle for Genitourinary Oncology at Dana-Farber Most cancers Institute and co-leader of the Kidney Most cancers Program at Dana-Farber Most cancers Institute and Harvard Most cancers Middle, each in Boston.
READ MORE: Navigating Vitamin, Frailty Throughout Kidney or Bladder Most cancers Is Key
At ESMO, Choueiri sat down with CURE® to debate Fotivda and what sufferers ought to anticipate concerning unwanted side effects.
Transcript:
[Fotivda (tivozanib)] is a really clear VEGF TKI, really, the aspect impact profile having been in contrast in a randomized part 3 [trial], to cabozantinib, [Lenvima (lenvatinib)], largely to [Nexavar (sorafenib)] within the TIVO-3 examine.
However I can inform you, it is on track [with] VEGF toxicity. You see hypertension, you see diarrhea. The half-life (period of time for the physique to course of the drug’s dose in half) is brief, and it has been on in our palms for a while. So, we all know how one can scale back doses [and] enhance once more [or] maintain the drug. It wants fixed take care of hypertension, diarrhea, and so on. However our crew right here, together with our suppliers [and] nursing employees, have been fairly acquainted for a while with managing VEGF TKI unwanted side effects.
This transcript has been edited for readability and conciseness.
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