Srinivas, U. S. et al. ROS and the DNA harm response in most cancers. Redox Biol. 25, 101084 (2019).
Parplys, A. C. et al. DNA harm by X-rays and their impression on replication processes. Radiother. Oncol. 102, 466–471 (2012).
Salar, R. Okay. & Purewal, S. S. Enchancment of DNA harm safety and antioxidant exercise of biotransformed pearl millet. Biocatal. Agric. Biotechnol. 8, 221–227 (2016).
Cadet, J., Douki, T. & Ravanat, J. L. Oxidatively generated base harm to mobile DNA. Free Radic. Biol. Med. 49, 9–21 (2010).
Sedelnikova, O. A. et al. Position of oxidatively induced DNA lesions in human pathogenesis. Mut. Res. 704, 152–159 (2010).
Hwang, E. S. & Bowen, P. E. DNA harm, a biomarker of carcinogenesis: its measurement and modulation by food regimen and setting. Crit. Rev. Meals Sci. Nutr. 47, 27–50 (2007).
Jackson, S. P. & Bartek, J. The DNA-damage response in human biology and illness. Nature 461, 1071–1078. https://doi.org/10.1038/nature08467 (2009).
Kaur, R., Kaur, M. & Purewal, S. S. Impact of incorporation of flaxseed to wheat rusks: Antioxidant, dietary, sensory traits, and in vitro DNA harm safety exercise. J. Meals Course of. Preserv. 42, e13585 (2018).
Salar, R. Okay. & Purewal, S. S. Phenolic content material, antioxidant potential and DNA harm safety of pearl millet cultivars of the North Indian area. Meals Meas. 11, 126–133 (2017).
Dexheimer, T.S. DNA restore pathways and mechanisms. In DNA Restore of Most cancers Stem Cells, 19–32 (Springer, 2013).
Lindahl, T. & Barnes, D. E. Restore of endogenous DNA harm. Chilly Spring Harb. Symp. Quant. Biol. 65, 127–133 (2000).
Hoeijmakers, J. H. DNA harm, growing old, and most cancers. N. Engl. J. Med. 361, 1475–1485 (2009).
O’Driscoll, M. et al. An outline of three new issues related to genetic instability: LIG4 syndrome, RS-SCID, and ATR-Seckel syndrome. DNA Restore 3, 1227–1235 (2004).
Altieri, F. et al. DNA harm and restore: From molecular mechanisms to well being implications. Antioxid. Redox Sign. 10, 891–938 (2008).
Molinaro, C., Martoriati, A. & Cailliau, Okay. Proteins from the DNA harm response: Regulation, dysfunction, and anticancer methods. Cancers 13, 3819 (2021).
Wang, Y. et al. Radiosensitization by irinotecan is attributed to G2/M part arrest, adopted by enhanced apoptosis, most likely via the ATM/Chk/Cdc25C/Cdc2 pathway in p53-mutant colorectal most cancers cells. Int. J. Oncol. 53, 1667–1680 (2018).
Gonzalez Besteiro, M. A. & Gottifredi, V. The fork and the kinase: A DNA replication story from a CHK1 perspective. Mutat. Res. Rev. Mutat. Res. 763, 168–180 (2015).
Fakhri, S., Abbaszadeh, F., Jorjani, M. & Pourgholami, M. H. The results of anticancer medicinal herbs on vascular endothelial development issue primarily based on pharmacological facets: A evaluation examine. Nutr. Most cancers 73, 1–15 (2019).
Zou, L. & Elledge, S. J. Sensing DNA harm via ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542–1548 (2003).
Weber, A. M. & Ryan, A. J. ATM and ATR as therapeutic targets in most cancers. Pharmacol. Ther. 149, 124–138 (2015).
Lee, Y. Y. et al. Anti-tumor results of Wee1 kinase inhibitor with radiotherapy in human cervical most cancers. Sci. Rep. 9, 15394 (2019).
Sancar, A., Lindsey-Boltz, L. A., Unsal-Kacmaz, Okay. & Linn, S. Molecular mechanisms of mammalian DNA restore and the DNA harm checkpoints. Annu. Rev. Biochem. 73, 39–85 (2004).
Ochwang’i, D. O. et al. Medicinal crops utilized in remedy and administration of most cancers in Kakamega County Kenya. J. Ethnopharmacol. 151, 1040–1055 (2014).
Pandey, P., Khan, F., Qari, H. A. & Oves, M. Rutin (Bioflavonoid) as cell signaling pathway modulator: Prospects in remedy and chemoprevention. Prescribed drugs (Basel) 14, 1069 (2021).
Nadaf, Okay. & Badhe, P. In-silico examine of oyster mushroom (Pleurotus ostreatus) focusing on PARP protein (4UND). Preprints 2021, 2021080512 (2021). https://doi.org/10.20944/preprints202108.0512.v1
Gosavi, H.D. & Badhe, P. In silico examine of Silybum marianum focusing on PARP protein (4UND protein). Preprints 2021, 2021080384 (2021). https://doi.org/10.20944/preprints202108.0384.v1
Shelke, S. & Badhe, P. In-silico examine of Agaricus bisporus on DNA damaging protein. Preprints 2021, 2021090138 (2021). https://doi.org/10.20944/preprints202109.0138.v1
Jacob, Reed B., “Dockomatic: An Rising Useful resource to Handle Molecular Docking” (2012). Boise State College Theses and Dissertations. 297.
Daina, A., Michielin, O. & Zoete, V. SwissADME: A free internet software to guage pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci. Rep. 7, 42717 (2017).
Pires, D. E., Blundell, T. L. & Ascher, D. B. pkCSM: Predicting small-molecule pharmacokinetic and toxicity properties utilizing graph-based signatures. J. Med. Chem. 58(9), 4066–4072 (2015).
Badhe, P. Characterisation of fractions from Andrographis paniculata and Silybum marianum plant extracts that shield human cells
towards DNA harm. Accessible at: http://bura.brunel.ac.uk/deal with/2438/14796 (Brunel College London, 2016).
Saad, B. et al. Analysis of medicinal plant hepatotoxicity in co-cultures of hepatocytes and monocytes. Evid.-Based mostly Comp. Different Med. 3, 93–98 (2006).
Patlolla, A. Okay., Barnes, C., Hackett, D. & Tchounwou, P. B. Potassium dichromate induced cytotoxicity, genotoxicity and oxidative stress in human liver carcinoma (HepG2) cells. Int. J. Environ. Res. Public Well being 6(2), 643–653 (2009).
Prakash, A., Rigelhof, F. & Miller, E. Antioxidant exercise. Medallion Laboratories Analytical Progress 19, 1–4 (2001).
Kalim, M. D., Bhattacharyya, D., Banerjee, A. & Chattopadhyay, S. Oxidative DNA harm preventive exercise and antioxidant potential of crops utilized in Unani system of medication. BMC Complement. Altern. Med. 10, 1–11 (2010).
Hazra, B., Biswas, S. & Mandal, N. Antioxidant and free radical scavenging exercise of Spondias pinata. BMC Complement. Altern. Med. 8, 1 (2008).
Fontana, M., Mosca, L. & Rosei, M. A. Interplay of enkephalins with oxyradicals. Biochem. Pharmacol. 61, 1253–1257 (2001).
Amaya, A., Stopper, H., Žegura, B., Dusinska, M., & Møller, P. Do cytotoxicity and cell demise trigger false constructive ends in the in vitro comet assay? Mutat. Res. Genet. Toxicol. Environ. Mutagen. https://doi.org/10.1016/j.mrgentox.2022.503520 (2022).
Ji, Y. et al. A high-throughput comet assay strategy for
assessing mobile DNA harm. J. Vis. Exp. https://doi.org/10.3791/63559 (2022).
Alshwyeh, H. A. et al. Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung most cancers cells. Mol. Cell. Oncol. https://doi.org/10.1080/23723556.2023.2299046 (2024).
Nahar, J. et al. Roasting extract of Handroanthus impetiginosus enhances its anticancer exercise in A549 lung most cancers cells and improves its antioxidant and anti inflammatory results in regular cells. Appl. Sci. 13, 13171. https://doi.org/10.3390/app132413171 (2023).
Li, Q. et al. Rutin’s results on cell viability and apoptosis in gastric most cancers. J. Most cancers Res. Ther. 11, 6407210. https://doi.org/10.1155/2019/6407210 (2019).
Ganash, M. Genotoxic and antitumor exercise of pollen grains towards prostate most cancers cell line: Pharmaceutical Science-Botany for Medicinal Science. Int. J. Life Sci. Pharma Res. 11, 36–46. https://doi.org/10.22376/ijpbs/lpr.2021.12.3.P36-46 (2022).
Rusmana, D. et al. Antioxidant exercise of Phyllanthus niruri extract, rutin and quercetin. Indones. Biomed. J. 9, 84–90 (2017).
Limanto, A., Simamora, A., Santoso, A. W. & Timotius, Okay. H. Antioxidant, α-glucosidase inhibitory exercise and molecular docking examine of gallic acid, quercetin and rutin: A comparative examine. Mol. Cell. Biomed. Sci. 3, 67–74. https://doi.org/10.21705/mcbs.v3i2.60 (2019).
Rana, M. N. & Tangpong, J. In vitro free radical scavenging and anti-genotoxic actions of Thunbergia laurifolia aqueous leaf extract. J. Well being Res. 31, 127–133. https://doi.org/10.14556/jhr.2017.16 (2017).
Fu, H., Lin, M., Katsumura, Y. & Muroya, Y. Free-radical scavenging actions of silybin and its analogues: A pulse radiolysis examine. Int. J. Chem. Kinet. 43, 590–597 (2011).
Moon, J. Y. et al. Free radical-scavenging actions and cytoprotective impact of polyphenol-rich ethyl acetate fraction of guava (Psidium cattleianum) leaves on H2O2-treated HepG2 cell. J. Korean Soc. Appl. Biol. Chem. 56, 687–694. https://doi.org/10.1007/s13765-013-3156-z (2013).
Yang, X., Zhao, Y., Gu, Q., Chen, W. & Guo, X. Results of naringin on postharvest storage high quality of bean sprouts. Meals 11, 2294. https://doi.org/10.3390/foods11152294 (2022).
Peng, F. et al. The appliance of deep eutectic solvent on the extraction and in vitro antioxidant exercise of rutin from Sophora japonica bud. J. Meals Sci. Technol. 55, 2326–2333. https://doi.org/10.1007/s13197-018-3151-9 (2018).
Marthandan, S., Priebe, S., Hemmerich, P., Klement, Okay. & Diekmann, S. Lengthy-term quiescent fibroblast cells transit into senescence. PLoS One 9, e115597. https://doi.org/10.1371/journal.pone.0115597 (2014).
Chen, B. R. et al. Quiescent fibroblasts are extra energetic in mounting strong inflammatory responses than proliferative fibroblasts. PLoS One 7, e49232. https://doi.org/10.1371/journal.pone.0049232 (2012).
Bryant, H. E. et al. Particular killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase. Nature 434, 913–917 (2005).
Farmer, H. et al. Focusing on the DNA restore defect in BRCA mutant cells as a therapeutic technique. Nature 434, 917–921 (2005).
Al-Rajhi, A. M. H. et al. Anticancer, anticoagulant, antioxidant and antimicrobial actions of Thevetia peruviana latex with molecular docking of antimicrobial and anticancer actions. Molecules 27, 3165. https://doi.org/10.3390/molecules27103165 (2022).
Al-Areer, N. W. et al. Quantitative evaluation of whole phenolic and flavonoid compounds in numerous extracts from ginger plant (Zingiber officinale) and analysis of their anticancer impact towards colorectal most cancers cell strains. Pharmacia 70, 905–919. https://doi.org/10.3897/pharmacia.70.e103936 (2023).
Ghasemzadeh, A., Jaafar, H. Z., Rahmat, A. & Devarajan, T. Analysis of bioactive compounds, pharmaceutical high quality, and anticancer exercise of curry leaf (Murraya koenigii L.). Evid. Based mostly Complement. Alternat. Med. 2014, 873803. https://doi.org/10.1155/2014/873803 (2014).
Cirmi, S. et al. Chemopreventive brokers and inhibitors of most cancers hallmarks: Might citrus supply new views?. Vitamins 8, 698. https://doi.org/10.3390/nu8110698 (2016).
Madureira, M. B. et al. Naringenin and hesperidin as promising alternate options for prevention and co-adjuvant remedy for breast most cancers. Antioxidants 12, 586. https://doi.org/10.3390/antiox12030586 (2023).
Jing, L. J., Mohamed, M., Rahmat, A. & Abu Bakar, M. F. Phytochemicals, antioxidant properties and anticancer investigations of the completely different components of a number of gingers species (Boesenbergia rotunda, Boesenbergia pulchella var attenuata and Boesenbergia armeniaca). J. Med. Vegetation Res. 4, 27–32. https://doi.org/10.5897/JMPR09.308 (2010).
Stabrauskiene, J., Kopustinskiene, D. M., Lazauskas, R. & Bernatoniene, J. Naringin and naringenin: Their mechanisms of motion and the potential anticancer actions. Biomedicines 10, 1686. https://doi.org/10.3390/biomedicines10071686 (2022).
Egbuna, C. et al. Wnt/β-catenin signaling pathway inhibitors, glycyrrhizic acid, solanine, polyphyllin I, crocin, hypericin, tubeimoside-1, diosmin, and rutin in medicinal crops have higher binding affinities and anticancer properties: Molecular docking and ADMET examine. Meals Sci. Nutr. 11, 4155–4169. https://doi.org/10.1002/fsn3.3405 (2023).