Presence of Fusobacterium nucleatum in relation to affected person survival and an acidic setting in oesophagogastric junction and gastric cancers


  • Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, et al. International Most cancers Observatory: Most cancers At the moment. [(accessed on 1 Feb 2023)]. Accessible on-line: https://gco.iarc.fr/at this time

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. International Most cancers Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Nations. CA Most cancers J Clin. 2021;71:209–49.

    PubMed 

    Google Scholar
     

  • Spechler SJ, Souza RF. Barrett’s esophagus. N. Engl J Med. 2014;371:836–45.

    CAS 
    PubMed 

    Google Scholar
     

  • Quante M, Graham TA, Jansen M. Insights Into the Pathophysiology of Esophageal Adenocarcinoma. Gastroenterology. 2018;154:406–20.

    CAS 
    PubMed 

    Google Scholar
     

  • Doorakkers E, Lagergren J, Santoni G, Engstrand L, Brusselaers N. Helicobacter pylori eradication therapy and the danger of Barrett’s esophagus and esophageal adenocarcinoma. Helicobacter. 2020;25:e12688.

    CAS 
    PubMed 

    Google Scholar
     

  • Coleman HG, Xie SH, Lagergren J. The Epidemiology of Esophageal Adenocarcinoma. Gastroenterology. 2018;154:390–405.

    PubMed 

    Google Scholar
     

  • Reynolds JV, Preston SR, O’Neill B, Lowery MA, Baeksgaard L, Crosby T, et al. Trimodality remedy versus perioperative chemotherapy within the administration of regionally superior adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, section 3 trial. Lancet Gastroenterol Hepatol. 2023;8:1015–27.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Imamura Y, Watanabe M, Oki E, Morita M, Baba H. Esophagogastric junction adenocarcinoma shares traits with gastric adenocarcinoma: Literature overview and retrospective multicenter cohort research. Ann Gastroenterol Surg. 2021;5:46–59.

    PubMed 

    Google Scholar
     

  • Kato Okay, Doki Y, Ogata T, Motoyama S, Kawakami H, Ueno M, et al. First-line nivolumab plus ipilimumab or chemotherapy versus chemotherapy alone in superior esophageal squamous cell carcinoma: a Japanese subgroup evaluation of open-label, section 3 trial (CheckMate 648/ONO-4538-50). Esophagus. 2023;20:291–301.

    PubMed 

    Google Scholar
     

  • Janjigian YY, Shitara Okay, Moehler M, Garrido M, Salman P, Shen L, et al. First-line nivolumab plus chemotherapy versus chemotherapy alone for superior gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, section 3 trial. Lancet. 2021;398:27–40.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Integrative HMP (iHMP) Analysis Community Consortium. The Integrative Human Microbiome Venture. Nature. 2019;569:641–8.


    Google Scholar
     

  • Galeano Nino JL, Wu H, LaCourse KD, Kempchinsky AG, Baryiames A, Barber B, et al. Impact of the intratumoral microbiota on spatial and mobile heterogeneity in most cancers. Nature. 2022;611:810–7.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fan Y, Pedersen O. Intestine microbiota in human metabolic well being and illness. Nat Rev Microbiol. 2021;19:55–71.

    CAS 
    PubMed 

    Google Scholar
     

  • Sepich-Poore GD, Zitvogel L, Straussman R, Hasty J, Wargo JA, Knight R. The microbiome and human most cancers. Science. 2021;371:eabc4552.

  • Holt RA, Cochrane Okay. Tumor Potentiating Mechanisms of Fusobacterium nucleatum, A Multifaceted Microbe. Gastroenterology. 2017;152:694–6.

    PubMed 

    Google Scholar
     

  • Brennan CA, Garrett WS. Fusobacterium nucleatum – symbiont, opportunist and oncobacterium. Nat Rev Microbiol. 2019;17:156–66.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ugai T, Shimizu T, Kawamura H, Ugai S, Takashima Y, Usui G, et al. Inverse relationship between Fusobacterium nucleatum quantity and tumor CD274 (PD-L1) expression in colorectal carcinoma. Clin Transl Immunol. 2023;12:e1453.

    CAS 

    Google Scholar
     

  • Mima Okay, Sukawa Y, Nishihara R, Qian ZR, Yamauchi M, Inamura Okay, et al. Fusobacterium nucleatum and T Cells in Colorectal Carcinoma. JAMA Oncol. 2015;1:653–61.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mima Okay, Cao Y, Chan AT, Qian ZR, Nowak JA, Masugi Y, et al. Fusobacterium nucleatum in Colorectal Carcinoma Tissue In response to Tumor Location. Clin Transl Gastroenterol. 2016;7:e200.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mima Okay, Nishihara R, Qian ZR, Cao Y, Sukawa Y, Nowak JA, et al. Fusobacterium nucleatum in colorectal carcinoma tissue and affected person prognosis. Intestine. 2016;65:1973–80.

    CAS 
    PubMed 

    Google Scholar
     

  • Wang N, Fang JY. Fusobacterium nucleatum, a key pathogenic issue and microbial biomarker for colorectal most cancers. Developments Microbiol. 2023;31:159–72.

    CAS 
    PubMed 

    Google Scholar
     

  • Yang Y, Weng W, Peng J, Hong L, Yang L, Toiyama Y, et al. Fusobacterium nucleatum Will increase Proliferation of Colorectal Most cancers Cells and Tumor Growth in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Issue-kappaB, and Up-regulating Expression of MicroRNA-21. Gastroenterology. 2017;152:851–66.e824.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhang Y, Zhang L, Zheng S, Li M, Xu C, Jia D, et al. Fusobacterium nucleatum promotes colorectal most cancers cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-kappaB/ICAM1 axis. Intestine Microbes. 2022;14:2038852.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Castellarin M, Warren RL, Freeman JD, Dreolini L, Krzywinski M, Strauss J, et al. Fusobacterium nucleatum an infection is prevalent in human colorectal carcinoma. Genome Res. 2012;22:299–306.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, et al. Genomic evaluation identifies affiliation of Fusobacterium with colorectal carcinoma. Genome Res. 2012;22:292–8.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee DW, Han SW, Kang JK, Bae JM, Kim HP, Gained JK, et al. Affiliation Between Fusobacterium nucleatum, Pathway Mutation, and Affected person Prognosis in Colorectal Most cancers. Ann Surg Oncol. 2018;25:3389–95.

    PubMed 

    Google Scholar
     

  • Lee JB, Kim KA, Cho HY, Kim D, Kim WK, Yong D, et al. Affiliation between Fusobacterium nucleatum and affected person prognosis in metastatic colon most cancers. Sci Rep. 2021;11:20263.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yamamura Okay, Baba Y, Nakagawa S, Mima Okay, Miyake Okay, Nakamura Okay, et al. Human Microbiome Fusobacterium Nucleatum in Esophageal Most cancers Tissue Is Related to Prognosis. Clin Most cancers Res. 2016;22:5574–81.

    CAS 
    PubMed 

    Google Scholar
     

  • Yamamura Okay, Baba Y, Miyake Okay, Nakamura Okay, Shigaki H, Mima Okay, et al. Fusobacterium nucleatum in gastroenterological most cancers: Analysis of measurement strategies utilizing quantitative polymerase chain response and a literature overview. Oncol Lett. 2017;14:6373–8.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nomoto D, Baba Y, Liu Y, Tsutsuki H, Okadome Okay, Harada Okay, et al. Fusobacterium nucleatum promotes esophageal squamous cell carcinoma development through the NOD1/RIPK2/NF-kappaB pathway. Most cancers Lett. 2022;530:59–67.

    CAS 
    PubMed 

    Google Scholar
     

  • Di Pilato V, Freschi G, Ringressi MN, Pallecchi L, Rossolini GM, Bechi P. The esophageal microbiota in well being and illness. Ann N. Y Acad Sci. 2016;1381:21–33.

    PubMed 

    Google Scholar
     

  • Guo Y, Cao XS, Zhou MG, Yu B. Gastric microbiota in gastric most cancers: Completely different roles of Helicobacter pylori and different microbes. Entrance Cell Infect Microbiol. 2022;12:1105811.

    PubMed 

    Google Scholar
     

  • Guccione C, Yadlapati R, Shah S, Knight R, Curtius Okay. Challenges in Figuring out the Position of Microbiome Evolution in Barrett’s Esophagus and Development to Esophageal Adenocarcinoma. Microorganisms. 2021;9:2003.

  • Brusilovsky M, Bao R, Rochman M, Kemter AM, Nagler CR, Rothenberg ME. Host-Microbiota Interactions within the Esophagus Throughout Homeostasis and Allergic Irritation. Gastroenterology. 2022;162:521–34.e528.

    CAS 
    PubMed 

    Google Scholar
     

  • Yang L, Lu X, Nossa CW, Francois F, Peek RM, Pei Z. Irritation and intestinal metaplasia of the distal esophagus are related to alterations within the microbiome. Gastroenterology. 2009;137:588–97.

    PubMed 

    Google Scholar
     

  • Muszynski D, Kudra A, Sobocki BK, Folwarski M, Vitale E, Filetti V, et al. Esophageal most cancers and bacterial a part of intestine microbiota – A multidisciplinary perspective. Entrance Cell Infect Microbiol. 2022;12:1057668.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shao D, Vogtmann E, Liu A, Qin J, Chen W, Abnet CC, et al. Microbial characterization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-risk area of China. Most cancers. 2019;125:3993–4002.

    CAS 
    PubMed 

    Google Scholar
     

  • Liou JM, Chen CC, Chang CM, Fang YJ, Bair MJ, Chen PY, et al. Lengthy-term adjustments of intestine microbiota, antibiotic resistance, and metabolic parameters after Helicobacter pylori eradication: a multicentre, open-label, randomised trial. Lancet Infect Dis. 2019;19:1109–20.

    CAS 
    PubMed 

    Google Scholar
     

  • Freedberg DE, Kim LS, Yang YX. The Dangers and Advantages of Lengthy-term Use of Proton Pump Inhibitors: Knowledgeable Overview and Finest Follow Recommendation From the American Gastroenterological Affiliation. Gastroenterology. 2017;152:706–15.

    CAS 
    PubMed 

    Google Scholar
     

  • Amieva M, Peek RM Jr. Pathobiology of Helicobacter pylori-Induced Gastric Most cancers. Gastroenterology. 2016;150:64–78.

    CAS 
    PubMed 

    Google Scholar
     

  • Schulz C, Schutte Okay, Koch N, Vilchez-Vargas R, Wos-Oxley ML, Oxley APA, et al. The energetic bacterial assemblages of the higher GI tract in people with and with out Helicobacter an infection. Intestine. 2018;67:216–25.

    CAS 
    PubMed 

    Google Scholar
     

  • Boehm ET, Thon C, Kupcinskas J, Steponaitiene R, Skieceviciene J, Canbay A, et al. Fusobacterium nucleatum is related to worse prognosis in Lauren’s diffuse sort gastric most cancers sufferers. Sci Rep. 2020;10:16240.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lagergren J, Lagergren P. Current developments in esophageal adenocarcinoma. CA Most cancers J Clin. 2013;63:232–48.

    PubMed 

    Google Scholar
     

  • Cossentino MJ, Wong RK. Barrett’s esophagus and threat of esophageal adenocarcinoma. Semin Gastrointest Dis. 2003;14:128–35.

    PubMed 

    Google Scholar
     

  • Pohl H, Wrobel Okay, Bojarski C, Voderholzer W, Sonnenberg A, Rosch T, et al. Danger elements within the growth of esophageal adenocarcinoma. Am J Gastroenterol. 2013;108:200–7.

    PubMed 

    Google Scholar
     

  • Gao P, Cai N, Yang X, Yuan Z, Zhang T, Lu M, et al. Affiliation of Helicobacter pylori and gastric atrophy with adenocarcinoma of the esophagogastric junction in Taixing, China. Int J Most cancers. 2022;150:243–52.

    CAS 
    PubMed 

    Google Scholar
     

  • Johnson DA, Fennerty MB. Heartburn severity underestimates erosive esophagitis severity in aged sufferers with gastroesophageal reflux illness. Gastroenterology. 2004;126:660–4.

    PubMed 

    Google Scholar
     

  • Rubinstein MR, Wang X, Liu W, Hao Y, Cai G, Han YW. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling through its FadA adhesin. Cell Host Microbe. 2013;14:195–206.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu B, Crampton SP, Hughes CC. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity. 2007;26:227–39.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shi S, Liu Y, Wang Z, Jin X, Yan W, Guo X, et al. Fusobacterium nucleatum induces colon anastomosis leak by activating epithelial cells to specific MMP9. Entrance Microbiol. 2022;13:1031882.

    PubMed 
    PubMed Central 

    Google Scholar
     

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