PSA Ranges Very Low Amongst Transgender Girls Receiving Estrogen

(HealthDay Information) — For transgender girls receiving estrogen, the median prostate-specific antigen (PSA) degree is 0.02 ng/mL, in response to a analysis letter printed on-line within the Journal of the American Medical Affiliation.

Farnoosh Nik-Ahd, MD, from the College of California, San Francisco, and colleagues decided PSA values amongst a nationwide cohort of transgender girls with out recognized prostate most cancers receiving estrogen. The inclusion standards had been met by 210 sufferers who underwent 852 PSA assessments.

The researchers discovered that the median PSA degree was 0.02 ng/mL, and the ninety fifth percentile worth was 0.6 ng/mL. In 36% of sufferers, PSA ranges had been undetectable (23% and 49% of these with out and with orchiectomy, respectively). In sensitivity analyses utilizing first PSA degree and the median of all PSA ranges per affected person, the PSA distributions had been comparable (median, 0.08 and 0.06 ng/mL; ninety fifth percentile, 0.7 and 0.5 ng/mL). Throughout the cohort, the very best PSA degree was 2.21 ng/mL.

“On this research, PSA values had been very low amongst transgender girls receiving estrogen, suggesting that the historic minimize level of 4 ng/mL, typically used as a threshold for additional analysis, is probably going far too excessive a threshold for this inhabitants,” the authors write.

One writer disclosed ties to the biopharmaceutical trade.