Focusing on the innate immune system in pediatric and grownup AML


  • Kantarjian H, Kadia T, DiNardo C, Daver N, Borthakur G, Jabbour E, et al. Acute myeloid leukemia: present progress and future instructions. Blood Most cancers J. 2021;11:41–66.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zwaan CM, Kolb EA, Reinhardt D, Abrahamsson J, Adachi S, Aplenc R, et al. Collaborative efforts driving progress in pediatric acute myeloid leukemia. J Clin Oncol. 2015;33:2949–62.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Isidori A, Cerchione C, Daver N, DiNardo C, Garcia-Manero G, Konopleva M, et al. Immunotherapy in acute myeloid leukemia: the place we stand. Entrance Oncol. 2021;11:656218.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Karlsson L, Cheuk D, De Moerloose B, Hasle H, Jahnukainen Ok, Juul-Dam KL, et al. Traits and end result of main resistant illness in paediatric acute myeloid leukaemia. Br J Haematol. 2023;201:757–65.

    CAS 
    PubMed 

    Google Scholar
     

  • Orti G, Barba P, Fox L, Salamero O, Bosch F, Valcarcel D. Donor lymphocyte infusions in AML and MDS: enhancing the graft-versus-leukemia impact. Exp Hematol. 2017;48:1–11.

    CAS 
    PubMed 

    Google Scholar
     

  • Krieger E, Qayyum R, Keating A, Toor A. Elevated donor inhibitory KIR with identified HLA interactions present safety from relapse following HLA matched unrelated donor HCT for AML. Bone Marrow Transplant. 2021;56:2714–22.

    CAS 
    PubMed 

    Google Scholar
     

  • Sweeney C, Vyas P. The graft-versus-leukemia impact in AML. Entrance Oncol. 2019;9:1217.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Forgeard N, Jestin M, Vexiau D, Chevillon F, Ricadat E, Peffault de Latour R, et al. Sexuality- and fertility-related points in ladies after allogeneic hematopoietic stem cell transplantation. Transplant Cell Ther. 2021;27:432.e1–6.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhao Y, Aldoss I, Qu C, Crawford JC, Gu Z, Allen EK, et al. Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL. Blood. 2021;137:471–84.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Koedijk JB, van der Werf I, Calkoen FG, Nierkens S, Kaspers GJL, Zwaan CM, et al. Paving the way in which for immunotherapy in pediatric acute myeloid leukemia: present information and the way in which ahead. Cancers. 2021;13:4364.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Subklewe M, Bücklein V, Sallman D, Daver N. Novel immunotherapies within the remedy of AML: is there hope? Hematol Am Soc Hematol Educ Program. 2023;2023:691–701.


    Google Scholar
     

  • Binnewies M, Roberts EW, Kersten Ok, Chan V, Fearon DF, Merad M, et al. Understanding the tumor immune microenvironment (TIME) for efficient remedy. Nat Med. 2018;24:541–50.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Koedijk JB, van der Werf I, Penter L, Vermeulen MA, Barneh F, Perzolli A, et al. A multidimensional evaluation reveals distinct immune phenotypes and tertiary lymphoid structure-like aggregates within the bone marrow of pediatric acute myeloid leukemia. medRxiv. 2023;30:2023.03.03.23286485.


    Google Scholar
     

  • Dufva O, Pölönen P, Brück O, Keränen MAI, Klievink J, Mehtonen J, et al. Immunogenomic panorama of hematological malignancies. Most cancers Cell. 2020;38:380–99.e13.

    CAS 
    PubMed 

    Google Scholar
     

  • Uy GL, Aldoss I, Foster MC, Sayre PH, Wieduwilt MJ, Advani AS, et al. Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia. Blood. 2021;137:751–62.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Daver N, Garcia-Manero G, Basu S, Boddu PC, Alfayez M, Cortes JE, et al. Efficacy, security, and biomarkers of response to azacitidine and nivolumab in relapsed/refractory acute myeloid leukemia: a nonrandomized, open-label, part II research. Most cancers Discov. 2019;9:370–83.

    CAS 
    PubMed 

    Google Scholar
     

  • Bruni D, Angell HK, Galon J. The immune contexture and Immunoscore in most cancers prognosis and therapeutic efficacy. Nat Rev Most cancers. 2020;20:662–80.

    CAS 
    PubMed 

    Google Scholar
     

  • Lamble AJ, Lind EF. Focusing on the immune microenvironment in acute myeloid leukemia: a deal with T cell immunity. Entrance Oncol. 2018;8:213.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vadakekolathu J, Rutella S. Escape from T-cell focusing on immunotherapies in acute myeloid leukemia. Blood. 2023;142:221–37.

  • Curran E, Corrales L, Kline J. Focusing on the innate immune system as immunotherapy for acute myeloid leukemia. Entrance Oncol. 2015;5:83.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Engblom C, Pfirschke C, Pittet MJ. The function of myeloid cells in most cancers therapies. Nat Rev Most cancers. 2016;16:447–62.

    CAS 
    PubMed 

    Google Scholar
     

  • Peranzoni E, Lemoine J, Vimeux L, Feuillet V, Barrin S, Kantari-Mimoun C, et al. Macrophages impede CD8 T cells from reaching tumor cells and restrict the efficacy of anti-PD-1 remedy. Proc Natl Acad Sci USA. 2018;115:E4041–50.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Miari KE, Guzman ML, Wheadon H, Williams MTS. Macrophages in acute myeloid leukaemia: vital gamers in remedy resistance and affected person outcomes. Entrance Cell Dev Biol. 2021;9:692800.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Al-Matary YS, Botezatu L, Opalka B, Hönes JM, Lams RF, Thivakaran A, et al. Acute myeloid leukemia cells polarize macrophages in direction of a leukemia supporting state in a Development issue independence 1 dependent method. Haematologica. 2016;101:1216–27.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu T, Dai Y. Tumor microenvironment and therapeutic response. Most cancers Lett. 2017;387:61–8.

    CAS 
    PubMed 

    Google Scholar
     

  • Awad RM, De Vlaeminck Y, Maebe J, Goyvaerts C, Breckpot Ok. Flip again the time: focusing on tumor infiltrating myeloid cells to revert most cancers development. Entrance Immunol. 2018;9:1977.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates most cancers development. Most cancers Res. 2019;79:4557–66.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Poupot M. Why goal innate immune cells in cancers? Cancers. 2021;13:690.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Park MD, Silvin A, Ginhoux F, Merad M. Macrophages in well being and illness. Cell. 2022;185:4259–79.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pittet MJ, Michielin O, Migliorini D. Scientific relevance of tumour-associated macrophages. Nat Rev Clin Oncol. 2022;19:402–21.

    PubMed 

    Google Scholar
     

  • Pyzer AR, Stroopinsky D, Rajabi H, Washington A, Tagde A, Coll M, et al. MUC1-mediated induction of myeloid-derived suppressor cells in sufferers with acute myeloid leukemia. Blood. 2017;129:1791–801.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Baragaño Raneros A, Martín-Palanco V, Fernandez AF, Rodriguez RM, Fraga MF, Lopez-Larrea C, et al. Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia. Genes Immun. 2015;16:71–82.

    PubMed 

    Google Scholar
     

  • Paczulla AM, Rothfelder Ok, Raffel S, Konantz M, Steinbacher J, Wang H, et al. Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature. 2019;572:254–9.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Coles SJ, Wang EC, Man S, Hills RK, Burnett AK, Tonks A, et al. CD200 expression suppresses pure killer cell operate and straight inhibits affected person anti-tumor response in acute myeloid leukemia. Leukemia. 2011;25:792–9.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, et al. Macrophage polarization in tumour development. Semin Most cancers Biol. 2008;18:349–55.

    CAS 
    PubMed 

    Google Scholar
     

  • Locati M, Curtale G, Mantovani A. Range, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol. 2020;15:123–47.

    CAS 
    PubMed 

    Google Scholar
     

  • Laviron M, Petit M, Weber-Delacroix E, Combes AJ, Arkal AR, Barthélémy S, et al. Tumor-associated macrophage heterogeneity is pushed by tissue territories in breast most cancers. Cell Rep. 2022;39:110865.

    CAS 
    PubMed 

    Google Scholar
     

  • Cheng S, Li Z, Gao R, Xing B, Gao Y, Yang Y, et al. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell. 2021;184:792–809.e23.

    CAS 
    PubMed 

    Google Scholar
     

  • Weinhäuser I, Pereira-Martins DA, Almeida LY, Hilberink JR, Silveira DRA, Quek L, et al. M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and bettering mitochondrial metabolism. Sci Adv. 2023;9:eadf8522.

    PubMed 

    Google Scholar
     

  • Brück O, Dufva O, Hohtari H, Blom S, Turkki R, Ilander M, et al. Immune profiles in acute myeloid leukemia bone marrow affiliate with affected person age, T-cell receptor clonality, and survival. Blood Adv. 2020;4:274–86.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mumme H, Thomas BE, Bhasin SS, Krishnan U, Dwivedi B, Perumalla P, et al. Single-cell evaluation reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia. Nat Commun. 2023;14:6209.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mussai F, De Santo C, Abu-Dayyeh I, Sales space S, Quek L, McEwen-Smith RM, et al. Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment. Blood. 2013;122:749–58.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chao MP, Takimoto CH, Feng DD, McKenna Ok, Gip P, Liu J, et al. Therapeutic focusing on of the macrophage immune checkpoint CD47 in myeloid malignancies. Entrance Oncol. 2020;9:1380.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu J, Wang L, Zhao F, Tseng S, Narayanan C, Shura L, et al. Pre-clinical improvement of a humanized anti-CD47 antibody with anti-cancer therapeutic potential. PLoS ONE. 2015;10:e0137345.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Daver NG, Vyas P, Kambhampati S, Al Malki MM, Larson RA, Asch AS, et al. Tolerability and efficacy of the anticluster of differentiation 47 antibody magrolimab mixed with azacitidine in sufferers with beforehand untreated AML: part Ib outcomes. J Clin Oncol. 2023;41:4893–904.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jaiswal S, Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to keep away from phagocytosis. Cell. 2009;138:271–85.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Home IG, Savas P, Lai J, Chen AXY, Oliver AJ, Teo ZL, et al. Macrophage-derived CXCL9 and CXCL10 are required for antitumor immune responses following immune checkpoint blockade. Clin Most cancers Res. 2020;26:487–504.

    CAS 
    PubMed 

    Google Scholar
     

  • Hoch T, Schulz D, Eling N, Gómez JM, Levesque MP, Bodenmiller B. Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes options of the response to immunotherapy. Sci Immunol. 2022;7:eabk1692.

    CAS 
    PubMed 

    Google Scholar
     

  • Tran Janco JM, Lamichhane P, Karyampudi L, Knutson KL. Tumor-infiltrating dendritic cells in most cancers pathogenesis. J Immunol. 2015;194:2985–91.

    PubMed 

    Google Scholar
     

  • Liu Ok, Nussenzweig MC. Origin and improvement of dendritic cells. Immunol Rev. 2010;234:45–54.

    CAS 
    PubMed 

    Google Scholar
     

  • Lucarini V, Melaiu O, Tempora P, D’Amico S, Locatelli F, Fruci D. Dendritic cells: behind the scenes of T-cell infiltration into the tumor microenvironment. Cancers. 2021;13:433.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Goc J, Germain C, Vo-Bourgais TK, Lupo A, Klein C, Knockaert S, et al. Dendritic cells in tumor-associated tertiary lymphoid constructions sign a Th1 cytotoxic immune contexture and license the optimistic prognostic worth of infiltrating CD8+ T cells. Most cancers Res. 2014;74:705–15.

    CAS 
    PubMed 

    Google Scholar
     

  • Koucký V, Bouček J, Fialová A. Immunology of plasmacytoid dendritic cells in strong tumors: a short assessment. Cancers. 2019;11:470.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sisirak V, Faget J, Gobert M, Goutagny N, Vey N, Treilleux I, et al. Impaired IFN-α manufacturing by plasmacytoid dendritic cells favors regulatory T-cell growth that will contribute to breast most cancers development. Most cancers Res. 2012;72:5188–97.

    CAS 
    PubMed 

    Google Scholar
     

  • Derolf AR, Laane E, Björklund E, Saft L, Björkholm M, Porwit A. Dendritic cells in bone marrow at analysis and after chemotherapy in grownup sufferers with acute myeloid leukaemia. Scand J Immunol. 2014;80:424–31.

    CAS 
    PubMed 

    Google Scholar
     

  • Kline DE, MacNabb BW, Chen X, Chan WC, Fosco D, Kline J. CD8α+ dendritic cells dictate leukemia-specific CD8+ T cell fates. J Immunol. 2018;201:3759–69.

    CAS 
    PubMed 

    Google Scholar
     

  • Zalmaï L, Viailly PJ, Biichle S, Cheok M, Soret L, Angelot-Delettre F, et al. Plasmacytoid dendritic cells proliferation related to acute myeloid leukemia: phenotype profile and mutation panorama. Haematologica. 2021;106:3056–66.

    PubMed 

    Google Scholar
     

  • Mohty M, Blaise D, Faucher C, Bardou VJ, Gastaut JA, Viens P, et al. Affect of plasmacytoid dendritic cells on end result after reduced-intensity conditioning allogeneic stem cell transplantation. Leukemia. 2005;19:1–6.

    CAS 
    PubMed 

    Google Scholar
     

  • Jaillon S, Ponzetta A, Di Mitri D, Santoni A, Bonecchi R, Mantovani A. Neutrophil variety and plasticity in tumour development and remedy. Nat Rev Most cancers. 2020;20:485–503.

    CAS 
    PubMed 

    Google Scholar
     

  • Bilen MA, Dutcher GMA, Liu Y, Ravindranathan D, Kissick HT, Carthon BC, et al. Affiliation between pretreatment neutrophil-to-lymphocyte ratio and end result of sufferers with metastatic renal-cell carcinoma handled with nivolumab. Clin Genitourin Most cancers. 2018;16:e563–75.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shaul ME, Fridlender ZG. Tumour-associated neutrophils in sufferers with most cancers. Nat Rev Clin Oncol. 2019;16:601–20.

    PubMed 

    Google Scholar
     

  • Luo Y, Xu Y, Li X, Shi X, Huang P, Chen Y, et al. A prognostic mannequin of seven immune genes to foretell total survival in childhood acute myeloid leukemia. Biomed Res Int. 2022;2022:7724220.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mushtaq MU, Chaudhary SG, Murthy GSG, Corridor AC, Atallah EL, Mattison RJ. Prognostic significance of neutrophil-to-lymphocyte ratio in relapsed/refractory acute myeloid leukemia. Blood. 2018;132:5246


    Google Scholar
     

  • Mika T, Ladigan S, Schork Ok, Turewicz M, Eisenacher M, Schmiegel W, et al. Monocytes-neutrophils-ratio as predictive marker for failure of first induction remedy in AML. Blood Cells Mol Dis. 2019;77:103–8.

    PubMed 

    Google Scholar
     

  • Derakhshani A, Vahidian F, Alihasanzadeh M, Mokhtarzadeh A, Lotfi Nezhad P, Baradaran B. Mast cells: a double-edged sword in most cancers. Immunol Lett. 2019;209:28–35.

    CAS 
    PubMed 

    Google Scholar
     

  • Shi S, Ye L, Yu X, Jin Ok, Wu W. Deal with mast cells within the tumor microenvironment: present information and future instructions. Biochim Biophys Acta Rev Most cancers. 2023;1878:188845.

    CAS 
    PubMed 

    Google Scholar
     

  • Ribatti D. Mast cells in lymphomas. Crit Rev Oncol Hematol. 2016;101:207–12.

    PubMed 

    Google Scholar
     

  • Mao Y, Feng Q, Zheng P, Yang L, Zhu D, Chang W, et al. Low tumor infiltrating mast cell density confers prognostic profit and displays immunoactivation in colorectal most cancers. Int J Most cancers. 2018;143:2271–80.

    CAS 
    PubMed 

    Google Scholar
     

  • Taskinen M, Karjalainen-Lindsberg ML, Leppä S. Prognostic affect of tumor-infiltrating mast cells in sufferers with follicular lymphoma handled with rituximab and CHOP. Blood. 2008;111:4664–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Somasundaram R, Connelly T, Choi R, Choi H, Samarkina A, Li L, et al. Tumor-infiltrating mast cells are related to resistance to anti-PD-1 remedy. Nat Commun. 2021;12:346.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sperr WR, Jordan JH, Baghestanian M, Kiener HP, Samorapoompichit P, Semper H, et al. Expression of mast cell tryptase by myeloblasts in a gaggle of sufferers with acute myeloid leukemia. Blood. 2001;98:2200–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Wang S, Zhao X, Wu S, Cui D, Xu Z. Myeloid-derived suppressor cells: key immunosuppressive regulators and therapeutic targets in hematological malignancies. Biomark Res. 2023;11:34.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Epperly R, Gottschalk S, Velasquez MP. A bump within the street: how the hostile AML microenvironment impacts CAR T cell remedy. Entrance Oncol. 2020;10:262.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Movahedi Ok, Guilliams M, Van den Bossche J, Van den Bergh R, Gysemans C, Beschin A, et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive exercise. Blood. 2008;111:4233–44.

    CAS 
    PubMed 

    Google Scholar
     

  • Hyun SY, Na EJ, Jang JE, Chung H, Kim SJ, Kim JS, et al. Immunosuppressive function of CD11b+ CD33+ HLA-DR myeloid-derived suppressor cells-like blast subpopulation in acute myeloid leukemia. Most cancers Med. 2020;9:7007–17.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Solar H, Li Y, Zhang ZF, Ju Y, Li L, Zhang BC, et al. Enhance in myeloid-derived suppressor cells (MDSCs) related to minimal residual illness (MRD) detection in grownup acute myeloid leukemia. Int J Hematol. 2015;102:579–86.

    CAS 
    PubMed 

    Google Scholar
     

  • Sallman DA, McLemore AF, Aldrich AL, Komrokji RS, McGraw KL, Dhawan A, et al. TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype. Blood. 2020;136:2812–23.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tohumeken S, Baur R, Böttcher M, Stoll A, Loschinski R, Panagiotidis Ok, et al. Palmitoylated proteins on AML-derived extracellular vesicles promote myeloid-derived suppressor cell differentiation by way of TLR2/Akt/mTOR signaling. Most cancers Res. 2020;80:3663–76.

    CAS 
    PubMed 

    Google Scholar
     

  • Challagundla KB, Smart PM, Neviani P, Chava H, Murtadha M, Xu T, et al. Exosome-mediated switch of microRNAs throughout the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Most cancers Inst. 2015;107:djv135.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhu X, Shen H, Yin X, Yang M, Wei H, Chen Q, et al. Macrophages derived exosomes ship miR-223 to epithelial ovarian most cancers cells to elicit a chemoresistant phenotype. J Exp Clin Most cancers Res. 2019;38:81.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang L, Jia B, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, et al. VISTA is very expressed on MDSCs and mediates an inhibition of T cell response in sufferers with AML. Oncoimmunology. 2018;7:e1469594.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lengthy AH, Highfill SL, Cui Y, Smith JP, Walker AJ, Ramakrishna S, et al. Discount of MDSCs with all-trans retinoic acid improves CAR remedy efficacy for sarcomas. Most cancers Immunol Res. 2016;4:869–80.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Regulation AMK, Valdes-Mora F, Gallego-Ortega D. Myeloid-derived suppressor cells as a therapeutic goal for most cancers. Cells. 2020;9:561.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Orange JS. Pure killer cell deficiency. J Allergy Clin Immunol. 2013;132:515–25.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cornel AM, Mimpen IL, Nierkens S. MHC class I downregulation in most cancers: underlying mechanisms and potential targets for most cancers immunotherapy. Cancers. 2020;12:1760.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guillaume J, Perzolli A, Boes M. Methods to beat low MHC-I expression in paediatric and grownup tumours. Immunother Adv. 2023;4:ltad028.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shin MH, Kim J, Lim SA, Kim J, Kim SJ, Lee KM. NK cell-based immunotherapies in most cancers. Immune Netw. 2020;20:e14.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Carrega P, Morandi B, Costa R, Frumento G, Forte G, Altavilla G, et al. Pure killer cells infiltrating human nonsmall-cell lung most cancers are enriched in CD56 vibrant CD16(-) cells and show an impaired functionality to kill tumor cells. Most cancers. 2008;112:863–75.

    PubMed 

    Google Scholar
     

  • Fauriat C, Simply-Landi S, Mallet F, Arnoulet C, Sainty D, Olive D, et al. Poor expression of NCR in NK cells from acute myeloid leukemia: evolution throughout leukemia remedy and affect of leukemia cells in NCRdull phenotype induction. Blood. 2007;109:323–30.

    CAS 
    PubMed 

    Google Scholar
     

  • Jamal E, Azmy E, Ayed M, Aref S, Eisa N. Scientific affect of proportion of pure killer cells and pure killer-like T cell inhabitants in acute myeloid leukemia. J Hematol. 2020;9:62–70.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Darji A, Desai N, Modi R, Khamar B, Rajkumar S. Institution of cell line with NK/NKT phenotype from myeloid NK cell acute leukemia. Leuk Res. 2017;61:77–83.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhigarev D, MacFarlane AW, Drenberg CD, Nejati R, Varshavsky A, Campbell KS. NK cells of acute myeloid leukemia sufferers exhibit exhausted phenotype with impaired useful exercise. Blood. 2021;138:4466.


    Google Scholar
     

  • Costa AFO, Kuznetsova V, Marani LO, Lopes IA, Binelli LS, Scheucher PS, et al. Dysregulated activating and inhibitory receptors on pure killer cells predicts immune escape and poor outcomes in acute myeloid leukemia. Blood. 2022;140:9113–4.


    Google Scholar
     

  • Sandoval-Borrego D, Moreno-Lafont MC, Vazquez-Sanchez EA, Gutierrez-Hoya A, López-Santiago R, Montiel-Cervantes LA, et al. Overexpression of CD158 and NKG2A inhibitory receptors and underexpression of NKG2D and NKp46 Activating receptors on NK cells in acute myeloid leukemia. Arch Med Res. 2016;47:55–64.

    CAS 
    PubMed 

    Google Scholar
     

  • Baessler T, Charton JE, Schmiedel BJ, Grünebach F, Krusch M, Wacker A, et al. CD137 ligand mediates reverse results in human and mouse NK cells and impairs NK-cell reactivity in opposition to human acute myeloid leukemia cells. Blood. 2010;115:3058–69.

    CAS 
    PubMed 

    Google Scholar
     

  • Kursunel MA, Esendagli G. A co-inhibitory alliance in myeloid leukemia: TIM-3/Galectin-9 complicated as a brand new goal for checkpoint blockade remedy. EBioMedicine. 2017;23:6–7.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hattori N, Kawaguchi Y, Sasaki Y, Shimada S, Murai S, Abe M, et al. Monitoring TIGIT/DNAM-1 and PVR/PVRL2 immune checkpoint expression ranges in allogeneic stem cell transplantation for acute myeloid leukemia. Biol Blood Marrow Transplant. 2019;25:861–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Szczepanski MJ, Szajnik M, Welsh A, Whiteside TL, Boyiadzis M. Blast-derived microvesicles in sera from sufferers with acute myeloid leukemia suppress pure killer cell operate by way of membrane-associated remodeling progress factor-beta1. Haematologica. 2011;96:1302–9.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stringaris Ok, Sekine T, Khoder A, Alsuliman A, Razzaghi B, Sargeant R, et al. Leukemia-induced phenotypic and useful defects in pure killer cells predict failure to attain remission in acute myeloid leukemia. Haematologica. 2014;99:836–47.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Szczepanski MJ, Szajnik M, Czystowska M, Mandapathil M, Strauss L, Welsh A, et al. Elevated frequency and suppression by regulatory T cells in sufferers with acute myelogenous leukemia. Clin Most cancers Res. 2009;15:3325–32.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L. Mesenchymal stem cells inhibit pure killer-cell proliferation, cytotoxicity, and cytokine manufacturing: function of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood. 2008;111:1327–33.

    CAS 
    PubMed 

    Google Scholar
     

  • Beldi-Ferchiou A, Caillat-Zucman S. Management of NK cell activation by immune checkpoint molecules. Int J Mol Sci. 2017;18:2129.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu G, Zhang Q, Yang J, Li X, Xian L, Li W, et al. Elevated TIGIT expressing NK cells with dysfunctional phenotype in AML sufferers correlated with poor prognosis. Most cancers Immunol Immunother. 2022;71:277–87.

    CAS 
    PubMed 

    Google Scholar
     

  • Blum WG, Mims AS. Treating acute myeloid leukemia within the trendy period: a primer. Most cancers. 2020;126:4668–77.

    PubMed 

    Google Scholar
     

  • Anderson J, Majzner RG, Sondel PM. Immunotherapy of neuroblastoma: details and hopes. Clin Most cancers Res. 2022;28:3196–206.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bayón-Calderón F, Toribio ML, González-García S. Details and challenges in immunotherapy for T-cell acute lymphoblastic leukemia. Int J Mol Sci. 2020;21:7685.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu J, Niu T. Pure killer cell-based immunotherapy for acute myeloid leukemia. J Hematol Oncol. 2020;13:167.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Klingemann H. Are pure killer cells superior CAR drivers? Oncoimmunology. 2014;3:e28147.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vatner RE, Formenti SC. Myeloid-derived cells in tumors: results of radiation. Semin Radiat Oncol. 2015;25:18–27.

    PubMed 

    Google Scholar
     

  • Xu J, Escamilla J, Mok S, David J, Priceman S, West B, et al. CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate most cancers. Most cancers Res. 2013;73:2782–94.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shree T, Olson OC, Elie BT, Kester JC, Garfall AL, Simpson Ok, et al. Macrophages and cathepsin proteases blunt chemotherapeutic response in breast most cancers. Genes Dev. 2011;25:2465–79.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mok S, Tsoi J, Koya RC, Hu-Lieskovan S, West BL, Bollag G, et al. Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition. BMC Most cancers. 2015;15:356.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jacamo RO, Mu H, Zhang QI, Chachad D, Zhiquiang W, Ma W, et al. Impact of CCL2/CCR2 blockade in acute myeloid leukemia. Blood. 2015;126:1348.


    Google Scholar
     

  • Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, et al. Selective depletion of macrophages reveals distinct, opposing roles throughout liver damage and restore. J Clin Make investments. 2005;115:56–65.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Burnett SH, Kershen EJ, Zhang J, Zeng L, Straley SC, Kaplan AM, et al. Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene. J Leukoc Biol. 2004;75:612–23.

    CAS 
    PubMed 

    Google Scholar
     

  • Jahchan NS, Mujal AM, Pollack JL, Binnewies M, Sriram V, Reyno L, et al. Tuning the tumor myeloid microenvironment to struggle most cancers. Entrance Immunol. 2019;10:1611.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bertini R, Allegretti M, Bizzarri C, Moriconi A, Locati M, Zampella G, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion damage. Proc Natl Acad Sci USA. 2004;101:11791–6.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Baselga J, Tabernero JM. Weekly docetaxel in breast most cancers: making use of medical knowledge to affected person remedy. Oncologist. 2001;6:26–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Kawasaki T, Kawai T. Toll-like receptor signaling pathways. Entrance Immunol. 2014;5:461.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Karime C, Wang J, Woodhead G, Mody Ok, Hennemeyer CT, Borad MJ, et al. Tilsotolimod: an investigational artificial toll-like receptor 9 (TLR9) agonist for the remedy of refractory strong tumors and melanoma. Skilled Opin Investig Medication. 2022;31:1–13.

    CAS 
    PubMed 

    Google Scholar
     

  • Shirota Y, Shirota H, Klinman DM. Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive exercise of myeloid-derived suppressor cells. J Immunol. 2012;188:1592–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Peng Y, Wang Y, Wang M, Lan J, Chen Y. Therapeutic purposes of toll-like receptors (TLRs) agonists in AML. Clin Transl Oncol. 2022;24:2319–29.

    CAS 
    PubMed 

    Google Scholar
     

  • Beck B, Dörfel D, Lichtenegger FS, Geiger C, Lindner L, Merk M, et al. Results of TLR agonists on maturation and performance of 3-day dendritic cells from AML sufferers in full remission. J Transl Med. 2011;9:151.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liljenfeldt L, Dieterich LC, Dimberg A, Mangsbo SM, Loskog AS. CD40L gene remedy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes. Most cancers Gene Ther. 2014;21:95–102.

    CAS 
    PubMed 

    Google Scholar
     

  • Allavena P, Piemonti L, Longoni D, Bernasconi S, Stoppacciaro A, Ruco L, et al. IL-10 prevents the differentiation of monocytes to dendritic cells however promotes their maturation to macrophages. Eur J Immunol. 1998;28:359–69.

    CAS 
    PubMed 

    Google Scholar
     

  • Ferretti E, Di Carlo E, Cocco C, Ribatti D, Sorrentino C, Ognio E, et al. Direct inhibition of human acute myeloid leukemia cell progress by IL-12. Immunol Lett. 2010;133:99–105.

    CAS 
    PubMed 

    Google Scholar
     

  • Yang AS, Lattime EC. Tumor-induced interleukin 10 suppresses the flexibility of splenic dendritic cells to stimulate CD4 and CD8 T-cell responses. Most cancers Res. 2003;63:2150–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Kerkar SP, Goldszmid RS, Muranski P, Chinnasamy D, Yu Z, Reger RN, et al. IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells inside mouse tumors. J Clin Make investments. 2011;121:4746–57.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Watkins SK, Egilmez NK, Suttles J, Stout RD. IL-12 quickly alters the useful profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. J Immunol. 2007;178:1357–62.

    CAS 
    PubMed 

    Google Scholar
     

  • Benekli M, Baumann H, Wetzler M. Focusing on sign transducer and activator of transcription signaling pathway in leukemias. J Clin Oncol. 2009;27:4422–32.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Benekli M, Xia Z, Donohue KA, Ford LA, Pixley LA, Baer MR, et al. Constitutive exercise of sign transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is related to brief disease-free survival. Blood. 2002;99:252–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Hossain DM, Dos Santos C, Zhang Q, Kozlowska A, Liu H, Gao C, et al. Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity. Blood. 2014;123:15–25.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, et al. Inhibiting Stat3 signaling within the hematopoietic system elicits multicomponent antitumor immunity. Nat Med. 2005;11:1314–21.

    CAS 
    PubMed 

    Google Scholar
     

  • Herrmann A, Kortylewski M, Kujawski M, Zhang C, Reckamp Ok, Armstrong B, et al. Focusing on Stat3 within the myeloid compartment drastically improves the in vivo antitumor features of adoptively transferred T cells. Most cancers Res. 2010;70:7455–64.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • He W, Zhu Y, Mu R, Xu J, Zhang X, Wang C, et al. A Jak2-selective inhibitor potently reverses the immune suppression by modulating the tumor microenvironment for most cancers immunotherapy. Biochem Pharm. 2017;145:132–46.

    CAS 
    PubMed 

    Google Scholar
     

  • Timosenko E, Hadjinicolaou AV, Cerundolo V. Modulation of cancer-specific immune responses by amino acid degrading enzymes. Immunotherapy. 2017;9:83–97.

    CAS 
    PubMed 

    Google Scholar
     

  • Manuel ER, Diamond DJ. A street much less traveled paved by IDO silencing: Harnessing the antitumor exercise of neutrophils. Oncoimmunology. 2013;2:e23322.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mangaonkar A, Mondal AK, Fulzule S, Pundkar C, Park EJ, Jillella A, et al. A novel immunohistochemical rating to foretell early mortality in acute myeloid leukemia sufferers primarily based on indoleamine 2,3 dioxygenase expression. Sci Rep. 2017;7:12892.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD Jr, et al. CD47 is an antagonistic prognostic issue and therapeutic antibody goal on human acute myeloid leukemia stem cells. Cell. 2009;138:286–99.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Goswami S, Anandhan S, Raychaudhuri D, Sharma P. Myeloid cell-targeted therapies for strong tumours. Nat Rev Immunol. 2023;23:106–20.

    CAS 
    PubMed 

    Google Scholar
     

  • Liu Y, Wang Y, Yang Y, Weng L, Wu Q, Zhang J, et al. Rising phagocytosis checkpoints in most cancers immunotherapy. Sign Transduct Goal Ther. 2023;8:104.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Solar W, et al. CD40 agonists alter tumor stroma and present efficacy in opposition to pancreatic carcinoma in mice and people. Science. 2011;331:1612–6.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang L, Chen X, Liu X, Kline DE, Teague RM, Gajewski TF, et al. CD40 ligation reverses T cell tolerance in acute myeloid leukemia. J Clin Make investments. 2013;123:1999–2010.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Georgoudaki AM, Prokopec KE, Boura VF, Hellqvist E, Sohn S, Östling J, et al. Reprogramming tumor-associated macrophages by antibody focusing on inhibits most cancers development and metastasis. Cell Rep. 2016;15:2000–11.

    CAS 
    PubMed 

    Google Scholar
     

  • Liang S, Cai J, Li Y, Yang R. 1,25-Dihydroxy-Vitamin D3 induces macrophage polarization to M2 by upregulating T-cell Ig-mucin-3 expression. Mol Med Rep. 2019;19:3707–13.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jiang X, Zhou T, Xiao Y, Yu J, Dou S, Chen G, et al. Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis. Oncoimmunology. 2016;5:e1211219.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Qian Y, Yang T, Liang H, Deng M. Myeloid checkpoints for most cancers immunotherapy. Chin J Most cancers Res. 2022;34:460–82.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ruggeri L, Capanni M, Urbani E, Perruccio Ok, Shlomchik WD, Tosti A, et al. Effectiveness of donor pure killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002;295:2097–100.

    CAS 
    PubMed 

    Google Scholar
     

  • Schlegel P, Ditthard Ok, Lang P, Mezger M, Michaelis S, Handgretinger R, et al. NKG2D signaling results in NK cell mediated lysis of childhood AML. J Immunol Res. 2015;2015:473175.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rubnitz JE, Inaba H, Ribeiro RC, Kilos S, Rooney B, Bell T, et al. NKAML: a pilot research to find out the protection and feasibility of haploidentical pure killer cell transplantation in childhood acute myeloid leukemia. J Clin Oncol. 2010;28:955–9.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bednarski JJ, Zimmerman C, Berrien-Elliott MM, Foltz JA, Becker-Hapak M, Neal CC, et al. Donor memory-like NK cells persist and induce remissions in pediatric sufferers with relapsed AML after transplant. Blood. 2022;139:1670–83.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nguyen R, Wu H, Kilos S, Inaba H, Ribeiro RC, Cullins D, et al. A part II medical trial of adoptive switch of haploidentical pure killer cells for consolidation remedy of pediatric acute myeloid leukemia. J Immunother Most cancers. 2019;7:81.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Berrien-Elliott MM, Cashen AF, Cubitt CC, Neal CC, Wong P, Wagner JA, et al. Multidimensional analyses of donor memory-like NK cells reveal new associations with response after adoptive immunotherapy for leukemia. Most cancers Discov. 2020;10:1854–71.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Romee R, Rosario M, Berrien-Elliott MM, Wagner JA, Jewell BA, Schappe T, et al. Cytokine-induced memory-like pure killer cells exhibit enhanced responses in opposition to myeloid leukemia. Sci Transl Med. 2016;8:357ra123.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Reusing SB, Vallera DA, Manser AR, Vatrin T, Bhatia S, Felices M, et al. CD16xCD33 bispecific killer cell engager (BiKE) as potential immunotherapeutic in pediatric sufferers with AML and biphenotypic ALL. Most cancers Immunol Immunother. 2021;70:3701–8.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stein AS, Bajel A, Fleming S, Jongen-Lavrencic M, Garciaz S, Maiti A, et al. An open-label, first-in-human, dose-escalation research of SAR443579 administered as single agent by intravenous infusion in sufferers with relapsed or refractory acute myeloid leukemia (R/R AML), B-cell acute lymphoblastic leukemia (B-ALL) or high-risk myelodysplasia (HR-MDS). Blood. 2022;140:7476–7.


    Google Scholar
     

  • Hofmann S, Schubert M-L, Wang L, He B, Neuber B, Dreger P, et al. Chimeric antigen receptor (CAR) T cell remedy in acute myeloid leukemia (AML). J Clin Med. 2019;8:200.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gurney M, O’Dwyer M. Realizing innate potential: CAR-NK cell therapies for acute myeloid leukemia. Cancers. 2021;13:1568.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bachanova V, Cooley S, Defor TE, Verneris MR, Zhang B, McKenna DH, et al. Clearance of acute myeloid leukemia by haploidentical pure killer cells is improved utilizing IL-2 diphtheria toxin fusion protein. Blood. 2014;123:3855–63.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shah NN, Baird Ok, Delbrook CP, Fleisher TA, Kohler ME, Rampertaap S, et al. Acute GVHD in sufferers receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation. Blood. 2015;125:784–92.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Berrien-Elliott MM, Becker-Hapak M, Cashen AF, Jacobs M, Wong P, Foster M, et al. Systemic IL-15 promotes allogeneic cell rejection in sufferers handled with pure killer cell adoptive remedy. Blood. 2022;139:1177–83.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hot Topics

    Related Articles