At AACR 2022 (eighth–thirteenth April) in New Orleans (LA, USA), we caught up with Kevan Shokat, Professor on the College of California, San Francisco (UCSF; CA, USA), and Investigator at Howard Hughes Medical Institute (MD, USA). Ok-RAS was the primary human oncogene found; nonetheless, for many years researchers struggled to discover a binding pocket for inhibitors to bind to it. Ok-RAS was regarded as an undruggable oncogene, till lastly in 2013, Kevan Shokat and his staff made a discovery that opened the Ok-RAS-inhibitor floodgates. On this interview, we chat to Kevan about his prize-winning discovery and the bespoke method that…
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