Scientific conduct and outcomes of breast most cancers in younger girls with germline BRCA pathogenic variants

1. These authors contributed equally: Lucia Del Mastro, Hatem A. Azim Jr.

Authors and Affiliations

1. Division of Inside Drugs and Medical Specialties (DIMI), Faculty of Drugs, College of Genova, Genova, Italy

   Matteo Lambertini & Lucia Del Mastro

2. Division of Medical Oncology, U.O.C, Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy

   Matteo Lambertini

3. Scientific Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy

   Marcello Ceppi & Marco Bruzzone

4. Division of Medical Oncology, Institut Curie, Paris, France

   Anne-Sophie Hamy

5. Division of Medical Oncology, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France

   Olivier Caron

6. Division of Medical Oncology, Dana-Farber Most cancers Institute, Boston, MA, USA

   Philip D. Poorvu & Ann H. Partridge

7. Hereditary Most cancers Genetics Group, Vall d’Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain

   Estela Carrasco & Judith Balmaña

8. Sharett Institute of Oncology, Hadassah-Hebrew College Medical Heart, Jerusalem, Israel

   Albert Grinshpun

9. Division of Basic Medical Oncology and Multidisciplinary Breast Centre, Leuven Most cancers Institute, College Hospitals Leuven, Leuven, Belgium

   Kevin Punie

10. Division of Surgical procedure, Centre Léon Bérard, Lyon, France

    Christine Rousset-Jablonski

11. Division of Surgical Sciences, Basic Surgical procedure III – Breast Surgical procedure, Fondazione IRCCS Policlinico San Matteo, College of Pavia, aBRCAdaBRA onlus, Pavia, Italy

    Alberta Ferrari

12. Breast Oncology Unit, Shaare Zedek Medical Centre and Division of Oncology, Sheba Medical Heart, Tel Hashomer, Jerusalem, Israel

    Shani Paluch-Shimon

13. Division of Oncology and Haematology, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy

    Angela Toss

14. Most cancers Genetics Unit, Bergonie Institute, Bordeaux, France

    Claire Senechal

15. Division of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

    Fabio Puglisi

16. Division of Drugs, College of Udine, Udine, Italy

    Fabio Puglisi

17. Division of Breast Most cancers and Reconstructive Surgical procedure, Maria Sklodowska-Curie Nationwide Analysis Institute of Oncology, Warsaw, Poland

    Katarzyna Pogoda

18. Division of Medical Oncology, INCLIVA College Hospital of Valencia, CIBERONC, Valencia, Spain

    Jose Alejandro Pérez-Fidalgo

19. Division of Medical Oncology, Division of Radiological, Oncological and Pathological Sciences, “La Sapienza” College of Rome, Rome, Italy

    Laura De Marchis

20. Gynecological Oncology, Candiolo Most cancers Institute, FPO – IRCCS, Candiolo, Turin, Italy

    Riccardo Ponzone

21. Medical Oncology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy

    Luca Livraghi

22. College of Siena, Siena, Italy

    Luca Livraghi

23. Departament of Oncology, Instituto do Most cancers do Estado de Sao Paulo – Faculdade de Medicina da Universidade de Sao Paulo, Pacaembu, Sao Paulo, Brazil

    Maria Del Pilar Estevez-Diz

24. Division of Analysis and Breast Tumors, Mexican Nationwide Most cancers Institute, Mexico Metropolis, Mexico

    Cynthia Villarreal-Garza

25. Breast Most cancers Heart, Hospital Zambrano Hellion, Tecnologico de Monterrey, San Pedro Garza Garcia, NL, Mexico

    Cynthia Villarreal-Garza & Hatem A. Azim Jr.

26. Division of Surgical procedure, Oncology and Gastroenterology, College of Padua, Padua, Italy

    Maria Vittoria Dieci

27. Medical Oncology 2, Veneto Institute of Oncology IOV – IRCCS, Padua, Italy

    Maria Vittoria Dieci

28. Division of Medical Oncology, Centre Henri Becquerel, Rouen, France

    Florian Clatot

29. Division of Medical Oncology, Breast Clinic, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium

    Francois P. Duhoux

30. Breast Unit of Southern Switzerland (CSSI), Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

    Rossella Graffeo

31. Breast Illness Unit, Saint-Louis Hospital, APHP, Université de Paris, INSERM U976, Paris, France

    Luis Teixeira

32. Obstetrics and Gynecology Division, Hospital Universitari Son Espases, Palma, Spain

    Octavi Córdoba

33. Oncology Division, Tel Aviv Sourasky Medical Heart and Sackler School of Drugs, Tel Aviv, Israel

    Amir Sonnenblick

34. Breast Unit, Champalimaud Scientific Heart, Champalimaud Basis, Lisbon, Portugal

    Arlindo R. Ferreira

35. Predictive Biomarkers and New Therapeutic Methods in Oncology, INSERM Unit 981, Gustave Roussy, Villejuif, France

    Antonio Di Meglio

36. Division of Genetics, Institut Curie, Paris, France

    Claire Saule

37. Gynecologic Oncology Division, European Institute of Oncology IRCCS, Milan, Italy

    Fedro A. Peccatori

38. Division of Drugs, Institut Jules Bordet and Université Libre de Bruxelles (U.L.B.), Brussels, Belgium

    Marie Daphne t’Kint de Roodenbeke

39. Knowledge Centre, Institut Jules Bordet and Université Libre de Bruxelles (U.L.B.), Brussels, Belgium

    Lieveke Ameye

40. Breast Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy

    Lucia Del Mastro

Contributions

Idea and design: M.L. and H.A.A. Jr. Acquisition, evaluation, or interpretation of information: M.L., M.C., A.S.H., O.C., P.D.P., E.C., A.G., Ok.P., C.R.J., A.F., S.P.S, A.T., C.S., F.P., Ok.P., J.A.P.F., L.D.M., R.P., L.L., M.D.P.E.D., C.V.G., M.V.D., F.C., F.P.D., R.G., L.T, O.C., A.S, A.R.F., A.H.P., A.D.M., C.S., F.A.P., M.B, L.A., M.D.T.Ok.D.R., J.B., L.D.M. and H.A.A. Jr. Drafting of the manuscript: M.L. Essential revision of the manuscript for vital mental content material: M.C., A.S.H., O.C., P.D.P., E.C., A.G., Ok.P., C.R.J., A.F., S.P.S, A.T., C.S., F.P., Ok.P., J.A.P.F., L.D.M., R.P., L.L., M.D.P.E.D., C.V.G., M.V.D., F.C., F.P.D., R.G., L.T, O.C., A.S, A.R.F., A.H.P., A.D.M, C.S., F.A.P., M.B, L.A., M.D.T.Ok.D.R., J.B., L.D.M. and H.A.A. Jr. Statistical evaluation: M.C., M.B. Administrative, technical, or materials help: M.L., M.C., A.S.H., O.C., P.D.P., E.C., A.G., Ok.P., C.R.J., A.F., S.P.S, A.T., C.S., F.P., Ok.P., J.A.P.F., L.D.M., R.P., L.L., M.D.P.E.D., C.V.G., M.V.D., F.C., F.P.D., R.G., L.T, O.C., A.S, A.R.F., A.H.P., A.D.M, C.S., F.A.P., M.B, L.A., M.D.T.Ok.D.R., J.B., L.D.M. and H.A.A. Jr. Remaining approval of the finished model: M.L., M.C., A.S.H., O.C., P.D.P., E.C., A.G., Ok.P., C.R.J., A.F., S.P.S, A.T., C.S., F.P., Ok.P., J.A.P.F., L.D.M., R.P., L.L., M.D.P.E.D., C.V.G., M.V.D., F.C., F.P.D., R.G., L.T, O.C., A.S, A.R.F., A.H.P., A.D.M, C.S., F.A.P., M.B, L.A., M.D.T.Ok.D.R., J.B., L.D.M. and H.A.A. Jr. Accountability for all features of the work: M.L., M.C., A.S.H., O.C., P.D.P., E.C., A.G., Ok.P., C.R.J., A.F., S.P.S, A.T., C.S., F.P., Ok.P., J.A.P.F., L.D.M., R.P., L.L., M.D.P.E.D., C.V.G., M.V.D., F.C., F.P.D., R.G., L.T, O.C., A.S, A.R.F., A.H.P., A.D.M, C.S., F.A.P., M.B, L.A., M.D.T.Ok.D.R., J.B., L.D.M. and H.A.A. Jr.

Corresponding writer

Correspondence to
Matteo Lambertini.