Quite than receiving definitive radiation therapy for localized illness, these sufferers might have obtained therapy aimed toward stopping the additional unfold of what was incorrectly recognized as metastatic illness
Thomas Hope
The multicenter retrospective diagnostic research included 167 prostate most cancers sufferers at varied illness states who have been imaged with bone scans and PSMA PET inside 100 days. Every research was interpreted by three blinded readers. Utilizing PSMA PET scans because the reference normal, researchers evaluated optimistic predictive worth, destructive predictive worth, and specificity for bone scans in addition to inter-reader reproducibility, positivity fee, uptake on PSMA PET, and variety of lesions.
Whereas the specificity of bone scans was discovered to be excessive and related throughout illness states, the optimistic predictive worth of bone scans at preliminary staging was discovered to be a lot decrease than within the total inhabitants. When in comparison with PSMA PET, greater than half (57%) of bone scans at preliminary staging have been discovered to include false-positive metastases.
“Quite than receiving definitive radiation therapy for localized illness, these sufferers might have obtained therapy aimed toward stopping the additional unfold of what was incorrectly recognized as metastatic illness,” mentioned Hope. “These outcomes carry into query tips on how to apply knowledge from scientific trials which are primarily based on bone scans to sufferers who obtain PSMA PET. Wanting on the huge image, this research highlights the significance of understanding how check traits influence affected person administration.”
Supply: Society of Nuclear Drugs and Molecular Imaging
