Gastric and gastroesophageal junction (G/GEJ) cancers, in any other case referred to as abdomen most cancers, is the fourth main reason for cancer-related dying worldwide, with the highest incidence charges occurring in Jap Asia and Jap Europe.1 It is difficult to diagnose and deal with because the majority of sufferers with gastric most cancers do not current signs in early phases.2 The truth is, greater than 80% of sufferers with gastric most cancers within the U.S. are identified at a complicated stage and face a poor prognosis and low general survival fee, with simply 7% of metastatic sufferers surviving to five years previous prognosis.3,4
With 769,000 deaths worldwide annually, gastric most cancers sufferers want extra therapy choices, particularly therapies concentrating on novel biomarkers.1,5 Two well-known biomarkers in gastric most cancers are HER2 and PD-L1, however there’s additionally an rising biomarker below investigation – the IIIb isoform of fibroblast progress issue receptor 2, referred to as FGFR2b.6,7
“Gastric most cancers poses a fancy therapy problem, requiring modern approaches to enhance outcomes for these sufferers,” stated Jean-Charles Soria, MD, PhD, senior vp and Oncology Therapeutic Space Head. “We’re dedicated to exploring the potential of concentrating on FGFR2b protein overexpression, which can have potential as a predictive biomarker, and we hope to unlock invaluable insights that will advance focused therapy choices.”
FGFR2b protein overexpression as an rising biomarker in gastric most cancers
FGFR2b is a cell receptor protein discovered on the floor of some sufferers’ tumor cells, and it performs a task in quite a few mobile capabilities, together with cell survival and progress.8 In gastric most cancers, the FGFR2b protein is overexpressed in 20-30% of instances* and could also be related to poor prognosis.7
Exploring the function of FGFR2b protein overexpression in gastric most cancers represents an thrilling potential for focused remedy.6
Detection of FGFR2b protein overexpression by means of immunohistochemistry (IHC) testing
Researchers can detect FGFR2b protein overexpression with a sort of testing methodology known as immunohistochemistry (IHC), nevertheless, no take a look at is at present accepted for medical diagnostic functions.9,10
Amgen’s continued dedication to innovation for sufferers with gastric most cancers
Developments in biomarker testing and exploration of focused therapy choices are crucial for tackling the challenges posed by the complexities of gastric most cancers.5,11
Amgen is exploring the total potential of FGFR2b protein overexpression and stays dedicated to exploring customized therapy choices for gastric most cancers sufferers, together with the development of late-stage medical trials evaluating potential therapies concentrating on the receptor protein in first-line gastric most cancers.
To study extra about FGFR2b protein overexpression and its function as an rising biomarker in G/GEJ cancers, go to www.FGFR2b.com.
*That is an approximate vary based mostly on 910 pre-screened sufferers for a Part 2 trial in regionally superior or metastatic G/GEJ most cancers, of which 274 sufferers (30%) had been prescreened constructive for FGFR2b any 2+/3+ tumor cell staining by IHC, and on the 155 enrolled topics, of which 96 topics (62%) exhibited FGFR2b ≥ 10% 2+/3+ tumor cell staining by IHC.7
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