Analysis Precedence Plan 2024-2029 – CIHR

Desk of Contents

1. Land Acknowledgement
2. Message from the Scientific Director
3. Technique at a Look
4. Our Strategic Framework
5. Most cancers within the twenty first Century
6. The Institute & Our Group
7. Our Analysis Precedence Setting Course of
8. Precedence Space 1: Refocus on Most cancers Prevention, Early Detection & Danger Discount
9. Precedence Space 2: Mitigate Therapy Toxicities to Enhance Most cancers Survivorship
10. Precedence Space 3: Remodel Most cancers Analysis By Information Technique & Superior Analytics
11. Cross-Reducing Rules
12. Acknowledgements
13. Contact Us
14. Appendix A: Alignment with the CIHR Strategic Plan 2021-2031
15. Appendix B: Deliberative Dialogue Workshop Members
16. Picture Credit
17. Footnotes

Land Acknowledgement

The Institute of Most cancers Analysis is hosted on the College Well being Community in Toronto. We respectfully acknowledge that the land on which we developed our strategic analysis priorities is the treaty territory of the Mississaugas of the Credit score First Nation, and ancestral and conventional lands of the Anishinaabe, Haudenosaunee, Ojibway/Chippewa and Huron-Wendat Nations. As an institute with nationwide attain, we acknowledge the ancestral and unceded territories of all of the First Nations, Inuit, and Métis Folks from coast to coast to coast, and honour their various histories and cultures. By our engagement, analysis, studying, and group actions, we attempt for respectful relationships with all Indigenous Peoples as we proceed on a path in direction of therapeutic, reconciliation, and self-determination.

Message from the Scientific Director

On behalf of the Institute of Most cancers Analysis (ICR) on the Canadian Institutes of Well being Analysis (CIHR), I’m excited to share our strategic analysis priorities for 2024-2029. As most cancers stays the main reason for dying in Canada – touching the lives of tens of millions of Canadians and their households every year – ICR continues its mission to assist life-changing most cancers analysis grounded in scientific excellence, innovation, inclusivity, and influence. Guiding this mission are our new strategic analysis priorities, which have been formed by the group, for the group.

These new priorities characterize ICR’s future instructions for the following 5 years, capitalizing on the deeper understanding of the essential parts driving most cancers growth and development acquired within the current a long time and elevated recognition and deal with well being inequities. As we embark on the following section of most cancers analysis, these precedence areas will construct on earlier developments, facilitate new improvements, determine cancer-related well being fairness gaps, and foster collaborative analysis by means of strategic investments, partnerships, and capability constructing. Canadian most cancers analysis is world-class. The articulated strategic targets will additional strengthen Canada’s world footprint as a pacesetter in most cancers analysis, benefiting the total range of most cancers sufferers and communities nationally and all over the world.

Integral to our Institute’s strategic targets is the CIHR Strategic Plan 2021-2031. CIHR’s imaginative and prescient for a more healthy future can solely be achieved by means of our shared duty to assist analysis excellence, improve Canadian well being analysis capability, Indigenous self-determination, well being fairness, and evidence-informed decision-making. These core themes are deeply embedded inside our strategic analysis priorities, reaffirming our dedication to CIHR’s imaginative and prescient for the perfect well being for all, powered by excellent analysis.

Following within the footsteps of outstanding scientific management on the Institute, it has been an honour and privilege to steer ICR’s strategic precedence setting course of. I wish to thank our deeply gifted most cancers analysis group, our Institute Advisory Board, our affected person and group companions, the ICR crew, and the devoted CIHR workers and administration for his or her engagement and contributions in launching these new analysis priorities.

Every small, however significant step in most cancers analysis makes a profound distinction within the lives of people and their households impacted by most cancers. Allow us to proceed collectively in direction of our shared imaginative and prescient of a cancer-free world.

Fei-Fei Liu, MD, FRCPC, FASTRO, FCAHS
Scientific Director, CIHR Institute of Most cancers Analysis

Technique at a Look

Regardless of main scientific advances in prevention, analysis, and therapy, most cancers stays the main reason for dying for Canadians and a illness whose influence has touched just about each particular person throughout the nation.

As one of many 13 CIHR Institutes, the Institute of Most cancers Analysis (ICR) helps a variety of analysis initiatives to strengthen Canada’s most cancers analysis footprint. For greater than 20 years, ICR has collaborated with its various most cancers analysis group nationally and internationally and different CIHR Institutes to assist world-class most cancers analysis. Within the subsequent 5 years, we are going to construct on these achievements to proceed our influence on most cancers management, together with advancing analysis to realize a nationwide understanding of cancer-related well being fairness gaps.

As we embark onto the following section, ICR is happy to share its Analysis Precedence Plan for 2024-2029, Amplifying Influence: Leveraging Most cancers Analysis to Improve the Well being of Canadians, encompassing three key analysis areas:

1. Refocus on Most cancers Prevention, Early Detection & Danger Discount. We’ll foster interdisciplinary analysis on the organic mechanisms underlying most cancers etiology linked with host, way of life, environmental, socio-economic, and different components that can allow enhancements in prevention, early detection, and danger discount for all individuals. Working carefully with a variety of companions, we are going to strengthen capability, mobilize information, and determine and handle boundaries to well being fairness skilled by traditionally excluded and underserved communities.
2. Mitigate Therapy Toxicities to Enhance Most cancers Survivorship. We’ll strengthen efforts to speed up analysis and construct capability in most cancers survivorship by higher connecting interdisciplinary researchers with various areas of experience and expertise and affected person companions reflecting the variety of individuals in Canada to accumulate a deeper understanding of the organic mechanisms underlying most cancers therapy toxicities.
3. Remodel Most cancers Analysis By Information Technique & Superior Analytics. We’ll assist to advertise a world-class most cancers analysis knowledge ecosystem by partaking and convening key stakeholders and companions to construct capability, coordinate and improve most cancers analysis knowledge sources, and advance the sharing and administration of analysis knowledge to facilitate superior analytics.

To realize these analysis priorities, ICR will play three complementary roles within the pan-Canadian most cancers analysis ecosystem. As a Funder, we are going to put money into modern, excessive influence analysis that addresses areas of essential, unmet want. As a Convenor, we are going to join members inside and past our various most cancers analysis group to share information, applied sciences, and sources to determine and capitalize on new areas for collaboration. As a Catalyst, we are going to work carefully with our companions throughout CIHR and past to place analysis into motion. By specializing in the three key analysis precedence areas outlined above, we’re decided to amplify our influence on the Canadian most cancers analysis panorama, and advance the world-class most cancers analysis that the total range of individuals dwelling in Canada each want and deserve.

Our Strategic Framework

Analysis Precedence Areas

1. Refocus on Most cancers Prevention, Early Detection & Danger Discount
2. Mitigate Therapy Toxicities to Enhance Most cancers Survivorship
3. Remodel Most cancers Analysis by means of Information Technique & Superior Analytics

Cross-Reducing Rules

• Collaborations & Partnerships
• Capability Constructing
• Data Mobilization & Implementation
• Affected person & Group Engagement
• Fairness, Variety & Inclusion
• Indigenous Peoples’ Well being & Properly-Being & Indigenous Rights

Our Values

• Excellence & Management
• Dedication to Collaboration
• Respect for Folks
• Integrity & Accountability

Most cancers within the twenty first Century

Most cancers stays one of many main causes of dying worldwide. In 2020, an estimated 19.3 million new most cancers instances and practically 10 million most cancers deaths occurred the world over^{Footnote 1}. By 2040, 16.4 million persons are anticipated to succumb to this illness globally^{Footnote 1}. In Canada, most cancers is the main reason for dying. Roughly 2 in 5 Canadians can be recognized with most cancers throughout their lifetime, and 1 in 4 will die of their illness^{Footnote 2}. An estimated 239,100 Canadians have been anticipated to be recognized with most cancers in 2023, with 86,700 deaths^{Footnote 2} – a quantity that’s more likely to be exacerbated by disruptions to most cancers care through the COVID-19 pandemic, resulting in later-stage diagnoses^{Footnote 3}. As such, most cancers poses a big burden on each the individuals affected and the well being care system. From a societal perspective, the financial burden of most cancers in Canada is substantial – cancer-related prices have been estimated to be $26.2 billion in 2021, with 30% being borne by sufferers and their households^{Footnote 4}.

Prior to now a long time, outstanding progress has been made in decreasing age-adjusted most cancers incidence and mortality worldwide. Technological improvements and scientific breakthroughs within the understanding, prevention, detection, and therapy of most cancers – starting from elevated accessibility to inexpensive genome sequencing, focused immunotherapies, mRNA vaccines, synthetic intelligence, circulating biomarkers, in vivo CRISPR screening, cryo-electron microscopy, and single-cell sequencing to call just a few – have accelerated progress towards this illness. Understanding and addressing the intersections between socio-economic, geographic, and demographic components throughout the most cancers continuum have additionally improved most cancers well being fairness throughout the globe.

Canada has a powerful world footprint in most cancers analysis, contributing to transformative, world-class analysis and offering scientific and strategic management to rising priorities and challenges. Partly, because of the advances in most cancers analysis and care previously a long time, there are presently greater than 1.5 million Canadians dwelling with and past most cancers^{Footnote 5}. Though the age-adjusted most cancers incidence is declining in Canada, absolutely the variety of new most cancers instances and deaths proceed to rise because of our rising and getting older inhabitants^{Footnote 6}. As such, continued funding in analysis spanning from prevention, to early detection, therapy, and survivorship is important to accelerating progress towards most cancers. This contains sustained funding to construct Canada’s well being analysis capability and inclusivity by coaching the following era of most cancers researchers, clinicians, and know-how builders, in addition to supporting essential analysis infrastructure.

Canada’s annual funding in most cancers analysis averages $500 million^{Footnote 7}. CIHR has invested greater than $1 billion in most cancers analysis over the previous 5 years, supporting analysis that has led to many essential breakthroughs for sufferers. Trying forward, ICR will execute on its new strategic analysis priorities, working carefully with its analysis and affected person communities, nationwide and worldwide funding companions, different Institutes inside CIHR, authorities departments and businesses, comparable to Well being Canada, the Public Well being Company of Canada, Innovation, Science and Financial Improvement Canada, Statistics Canada, the Canadian Institute for Well being Data, the Canadian Partnership Towards Most cancers, the Canadian Most cancers Analysis Alliance, the Canadian Affiliation of Provincial Most cancers Companies, and lots of others, to collectively scale back the burden of most cancers and maximize the advantages of most cancers analysis for the total range of individuals dwelling in Canada.

The Institute & Our Group

The Institute of Most cancers Analysis (ICR) is one in every of 13 Institutes of the Canadian Institutes of Well being Analysis (CIHR), Canada’s federal company that funds all features of well being analysis. ICR performs a dynamic position in strengthening Canada’s most cancers analysis footprint. We assist scientific excellence throughout all areas of most cancers analysis – prevention, screening, analysis, therapy, survivorship, and palliation – to scale back the rising incidence of most cancers in Canada and enhance the well being, well-being, and well being fairness of individuals in Canada. As a part of CIHR, our mandate spans all 4 pillars of well being analysis (biomedical analysis, scientific analysis, well being providers analysis, and social, cultural, environmental, and inhabitants well being analysis) and represents inter- and transdisciplinary approaches to most cancers analysis that considers a number of contexts, views, communities, and experiences. By its position as a funder, convenor, and catalyst throughout the most cancers ecosystem, ICR has greater than 20 years of historical past in supporting world-class most cancers analysis by means of:

• Catalyzing and supporting analysis
• Constructing Canada’s well being analysis capability
• Scientific management on Authorities of Canada and worldwide priorities
• Fostering nationwide and worldwide partnerships
• Data Mobilization Actions

Most cancers stays a world well being problem that requires the collective efforts of various stakeholders and companions. ICR brings collectively a group of greater than 4,700 stakeholders and companions from throughout Canada and the world to find, innovate, and handle most cancers’s biggest challenges. Our various group represents researchers, trainees, well being professionals, individuals with lived and dwelling expertise, households and caregivers, authorities departments and businesses, trade, group organizations, and funding businesses. As ICR is proudly community-oriented, the Institute provides intensive, inclusive alternatives for engagement, dialogue, and suggestions to tell and assist the design and supply of all its actions. Collectively, ICR goals to work with its world-class group to assist and enlarge the influence of most cancers analysis in Canada and all over the world.

ICR’s Analysis Precedence Plan will harken a brand new period of various and modern most cancers analysis initiatives and infrastructure. This plan can be integral in persevering with Canada’s long-standing tradition of analysis excellence and influence whereas supporting future generations of most cancers researchers.

The power in most cancers analysis lies in group and collaboration. The Canadian Most cancers Analysis Alliance is thrilled to see the entire alternatives embedded all through ICR’s Analysis Precedence Plan to assist collaborations and interdisciplinary crew science, accelerating information era throughout the most cancers continuum.

Our Analysis Precedence Setting Course of

ICR carried out a 14-month engagement course of to make sure its strategic priorities for the following 5 years have been knowledgeable by and co-created with our various communities of researchers, affected person companions, funding companions, authorities, non-government and trade representatives, and worldwide specialists in most cancers analysis, in addition to in collaboration with CIHR to make sure alignment with the CIHR Strategic Plan 2021-2031.

Pan-Canadian Lively Listening Tour

All through November 2022 to April 2023, greater than 250 members of our various analysis group, together with researchers, affected person companions, Indigenous communities, and funding companions throughout Canada offered their ideas and views on the present most cancers analysis panorama, challenges and alternatives, and the place funding and assist from ICR could be most impactful. The pan-Canadian insights highlighted three potential analysis precedence areas to be additional developed and refined.

Deliberative Dialogue Workshop (DDW)

In June 2023, greater than 100 attendees joined ICR in a one-and-a-half-day hybrid workshop fostering inclusive and wide-ranging discussions amongst various members of the most cancers analysis and affected person communities. The workshop centered on the three preliminary analysis precedence areas, exploring their distinctive alternatives and challenges, and the way they match into the broader Canadian, and worldwide most cancers analysis panorama to make sure ICR continues to strategically and equitably improve assist for the most cancers analysis group.

Group Engagement Survey

In July 2023, ICR launched a bilingual Group Engagement Survey to make sure broader group participation and the chance to additional construct upon the Pan-Canadian Lively Listening Tour and DDW insights.

Steerage & Endorsement from ICR’s Institute Advisory Board

All through our engagement course of, we sought steering from our Institute Advisory Board members to assist inform, enhance, and finally endorse the event and finalization of ICR’s three analysis precedence areas while making certain alignment with the CIHR Strategic Plan.

Witnessing the wealth of information, trade, and collaboration that was generated through the analysis precedence setting course of was unbelievable. It speaks volumes to the extraordinary engagement of the most cancers analysis group in Canada and its ardour for advancing most cancers analysis.

Providing my perspective within the analysis precedence setting course of was a watershed second in my advocacy journey. As a most cancers survivor, seeing most cancers survivorship represented on this plan makes me really feel seen and validated. It’s going to assist foster significant partnerships between affected person advocates and researchers.

Precedence Space 1: Refocus on Most cancers Prevention, Early Detection & Danger Discount

Most cancers is a posh and consistently evolving illness outlined by a large number of most cancers varieties, every characterised by distinctive organic mechanisms linking host, way of life, environmental, socio-economic, and different components that contribute to most cancers growth and development. The World Well being Group studies that between 30-50% of most cancers deaths are associated to modifiable danger issue exposures, and implementing current evidence-based prevention methods might be impactful.^{Footnote 8} Equally, in Canada, it’s estimated that roughly 4 in 10 most cancers instances may be doubtlessly prevented by modifying way of life and avoiding environmental and communicable danger components.^{Footnote 9}

Prior to now a long time, important insights have been acquired by means of integrative multi-omics approaches in most cancers analysis to determine affected person subgroups and mechanisms underlying most cancers growth. We at the moment are at a watershed second, the place we are able to harness these insights and produce them to bear to advance most cancers prevention. The event and uptake of higher diagnostic instruments and simpler danger discount measures would require a deeper understanding of the organic mechanisms linked with host, way of life, environmental, socio-economic, and different components that underpin most cancers growth and development throughout the varied inhabitants of Canada. Considerably enhanced funding in most cancers prevention and early detection analysis in Canada (Determine 1)^{Footnote 7} can be essential in producing proof that can drive personalised approaches to most cancers screening and danger discount, and assist inform public well being efforts that can promote uptake of those methods. Accelerating analysis on this area with the goal of decreasing the incidence of most cancers will finally change the trajectory of this illness for a lot of Canadians and past.

Determine 1: Canadian Most cancers Analysis Funding in Working Grants by Frequent Scientific Define Class primarily based on the 2005-2019 CCRA Canadian Most cancers Analysis Survey ($M)

ICR’s Strategic Route

Over the following 5 years, ICR will make investments to advance analysis in most cancers prevention, early detection, and danger discount by higher connecting researchers with various experience, whose collaborative efforts are required to harness organic insights linked with host, way of life, environmental, socio-economic, and different components to drive improvements within the prevention and early detection of most cancers. ICR will work carefully with a variety of companions throughout and past the Canadian most cancers analysis and affected person communities to construct capability and mobilize information within the areas of most cancers prevention, early detection, and danger discount, with the goal of additionally enhancing well being fairness in underserved communities and traditionally excluded populations. From researchers to trainees, and from sufferers and caregivers to clinicians and coverage makers, we consider that various voices carry useful insights. Solely by proactively, equitably, and inclusively partaking a spread of companions and collaborators will we have the ability to amplify the influence of our work.

Alignment to CIHR’s 2021-2031 Strategic Plan

Aligned with CIHR’s precedence to advance analysis excellence in all its range,^{Footnote 11} ICR is dedicated to strengthening assist for inter- and transdisciplinary crew science and enhancing nationwide and worldwide analysis collaborations. ICR will convene specialists and information customers with various backgrounds from a number of specialties and communities to outline and handle analysis priorities inside most cancers prevention and early detection that might be most pertinent to Canada. ICR shares CIHR’s dedication to strengthening Canada’s well being analysis capability by supporting the present and subsequent era of researchers to collaborate and lead in prevention and early detection analysis. We additionally actively assist CIHR’s mandate to foster and allow the mobilization of recent information to equitably and inclusively enhance the well being of individuals in Canada and all through the world.

ICR’s full alignment with CIHR’s strategic priorities may be present in Appendix A.

Objectives

1. Advance the understanding of the organic mechanisms underlying most cancers growth linked with host, way of life, environmental, socio-economic, and different components to allow enhancements in most cancers prevention, early detection, and danger discount.
2. Foster and allow crew science, particularly between biomedical researchers and researchers in well being providers and inhabitants and public well being.
3. Bridge the hole between analysis and scientific/public well being apply by means of information mobilization and implementation.

Actions

1. Encourage new inter- and transdisciplinary analysis initiatives to carry biology to most cancers prevention and early detection.
2. Construct relationships and platforms to raised join researchers with various areas of experience and expertise.
3. Advance group engagement all through the analysis course of.
4. Help capacity-building initiatives.

Measures of Success

1 – 3 Years

• Elevated variety of inter- and transdisciplinary analysis initiatives centered on most cancers prevention, early detection, and danger discount to foster integration throughout discovery, scientific, translational, well being providers, and inhabitants well being analysis.
• Development within the variety of analysis initiatives facilitating capability constructing in prevention and early detection analysis inclusive of the total range of individuals in Canada.

5 Years

• Elevated variety of analysis trials centered on novel most cancers prevention and early detection methods and instruments involving a range of populations.
• Elevated variety of collaborations or partnerships between researchers and trade to speed up prevention and early detection analysis.
• Development within the variety of accessible, inclusive information mobilization actions inside prevention and early detection analysis.

Influence

Improved public consciousness of most cancers prevention and early detection methods, resulting in their elevated utilization, and continued discount in age-standardized incidence of most cancers amongst the variety of individuals dwelling in Canada.

Most cancers prevention analysis has great capability to change the well being trajectories of tens of millions of Canadians. Advancing our understanding of what components influence most cancers danger and the way we are able to translate these analysis findings into public well being and apply is a well timed scientific endeavor.

Precedence Space 2: Mitigate Therapy Toxicities to Enhance Most cancers Survivorship

The variety of Canadians dwelling with or past most cancers has now climbed to greater than 1.5 million,^{Footnote 5} reflecting the numerous developments made in screening, early detection, therapeutics, and supportive care. There may be rising recognition that the journey of most cancers survivorship is advanced; individuals dwelling with and past most cancers could expertise signs and challenges within the months and years following therapy, considerably impacting their high quality of life. In 2018, an estimated 8 in 10 Canadians with most cancers reported bodily challenges after their therapy ended, and seven in 10 skilled emotional difficulties, together with melancholy.^{Footnote 12} Moreover, the appearance of recent most cancers therapies, comparable to immunotherapy, can even give rise to new toxicities not beforehand linked to most cancers therapies. Well being outcomes may be additional influenced not solely by pre-existing circumstances and genetic predispositions, but additionally by a variety of different social, cultural, environmental, structural, and organic determinants of well being.

Over the previous decade, important inroads have been made in understanding the fundamental mechanisms of illness states, starting from immunologic to metabolic dysregulations that will underpin the event of toxicities and hostile results from most cancers therapies. We’re on the cusp of understanding how and why unwanted side effects happen in sure sufferers and growing personalised methods to mitigate and even stop them. As such, centered efforts to put money into most cancers survivorship analysis in Canada will generate the proof wanted to enhance the standard of survival for many individuals in Canada. Because the most cancers survivor inhabitants grows, well being system leaders will face a number of interconnected challenges, from long-term affected person monitoring and caregiver assist to well being care planning and the availability of assist providers. A greater understanding of the influence of most cancers and its therapy on peoples’ lives making an allowance for determinants of well being and well being inequities can be crucial to tell coverage and apply, and finally carry concerning the desired enhancements in survivorship care and outcomes.

ICR’s Strategic Route

Over the following 5 years, ICR will strengthen efforts to speed up analysis and construct capability in most cancers survivorship by higher connecting researchers with various areas of experience and expertise with information customers, whose collaboration is required to combine biology and determinants of well being with survivorship. ICR will proactively interact sufferers as companions in analysis, whose enter can be pivotal in serving to researchers embed affected person views in prioritizing areas of focus, designing research, and measuring progress and influence. This collaborative method ensures that analysis and care align with the wants of Canada’s rising and various most cancers survivor inhabitants.

Alignment to CIHR’s 2021-2031 Strategic Plan

ICR shares CIHR’s dedication to assist a extra inclusive, complete idea of analysis excellence that embeds the ideas of fairness, range, inclusion, and Indigenous rights.^{Footnote 11} ICR will interact sufferers, caregivers, well being care suppliers, researchers, coverage makers, and the general public as energetic and ongoing collaborators throughout our actions as we goal to speed up survivorship analysis that considers the determinants of well being throughout the life course and addresses well being fairness gaps that exist in Canada, with the final word objective of informing well being apply and coverage. Aligned with CIHR’s precedence to strengthen Canada’s well being analysis capability, ICR may even improve its efforts to assist the present and subsequent era of researchers reflective of the variety of individuals in Canada to collaborate and lead in most cancers survivorship analysis.

ICR’s full alignment with CIHR’s strategic priorities may be present in Appendix A.

Objectives

1. Advance the understanding of the organic mechanisms underlying most cancers therapy toxicities linked with host, way of life, environmental, socio-economic, and different components to allow enhancements in most cancers survivorship.
2. Determine biomarkers for personalised care and therapy decision-making to enhance outcomes.
3. Prioritize the early engagement of a range of individuals with lived and dwelling expertise all through the analysis course of to reinforce cancer-related well being fairness.

Actions

1. Encourage inter- and transdisciplinary analysis initiatives to carry biology to most cancers survivorship, and to outline optimum fashions of care.
2. Create alternatives to realize enhanced participation of a range of traditionally excluded and underserved affected person companions and teams in survivorship analysis.
3. Foster significant connections between ICR, its researchers, and affected person companions.
4. Leverage current sources and construct capability to strengthen survivorship analysis.

Measures of Success

1 – 3 Years

• Elevated variety of inter- and transdisciplinary analysis initiatives centered on most cancers survivorship to foster integration throughout discovery, scientific, translational, well being providers, and inhabitants well being analysis.
• Elevated variety of focused analysis initiatives facilitating enhanced participation of various affected person accomplice teams.
• Development within the variety of analysis initiatives facilitating capability constructing in survivorship analysis.

5 Years

• Elevated variety of analysis trials centered on novel most cancers survivorship methods and instruments.
• Development within the variety of collaborations established between ICR, its researchers, and affected person companions, with each teams reflective of the variety of individuals in Canada.
• Elevated variety of care and assist fashions for improved most cancers survivorship throughout the nation.

Influence

Enhanced high quality of lifetime of Canadians dwelling with and past most cancers by means of the event and utilization of instruments that leverage personalised drugs to raised predict, stop, and handle therapy toxicities and hostile results.

As a younger mom dwelling with metastatic breast most cancers, it brings our household hope for the long run realizing that ICR is dedicated to world-class most cancers analysis with a particular deal with mitigating toxicities and enhancing survivorship, together with a 5-year strategic plan rooted in collaboration and partnerships.

Precedence Space 3: Remodel Most cancers Analysis By Information Technique & Superior Analytics

Large knowledge and knowledge science are remodeling the most cancers panorama. By enabling the evaluation of large-scale knowledge units, knowledge science has opened new prospects for most cancers analysis and care, resulting in potential breakthroughs in prevention, detection, analysis, and therapy. With extra knowledge being generated now than ever, it’s crucial that Canada has a transparent roadmap to information efforts to reinforce the gathering, integration, sharing, and use of most cancers knowledge, with the final word goal of reaching equitable, and improved well being outcomes for the total range of individuals in Canada. The Pan-Canadian Well being Information Constitution highlights a nationwide path ahead for strengthening the well being knowledge foundations within the nation.^{Footnote 13} The Pan-Canadian Most cancers Information Technique – led by the Canadian Partnership Towards Most cancers and the Canadian Most cancers Society – lays sturdy foundations for a cancer-specific knowledge technique focusing totally on administrative knowledge, and highlights First Nations, Inuit, and Métis-led efforts to advance knowledge and knowledge governance in Canada.^{Footnote 14} With Canada’s wealthy reservoir of most cancers analysis knowledge and an evolving knowledge science group, continued efforts to enhance well timed entry and efficient linkages and interoperability of information and knowledge methods, in addition to constructing knowledge science and analytics capability throughout the most cancers analysis group, can be important to capitalize on the total worth of most cancers knowledge and maximize the advantages of most cancers analysis for all Canadians.

ICR’s Strategic Route

Over the following 5 years, ICR will put money into efforts to foster a world-class most cancers analysis knowledge ecosystem in Canada. Constructing on current sources and frameworks set by the Pan-Canadian Well being Information Constitution and the Pan-Canadian Most cancers Information Technique, we are going to interact and convene key stakeholders and companions to raised perceive the breadth of all most cancers analysis knowledge sources throughout the nation, in addition to advance the sharing and administration of analysis knowledge inside our analysis ecosystem. We’ll carry collectively Canada’s analysis knowledge centres, networks, alliances, and initiatives to determine alternatives for collaboration and innovation, in addition to acknowledge knowledge gaps that should be addressed. Examples embrace however should not restricted to the CIHR-funded Pan-Canadian Genome Library, the Digital Well being and Discovery Platform, the Marathon of Hope Most cancers Centres Community, Genome Canada, the World Alliance for Genomics and Well being, the Canadian Institute for Superior Analysis, and the Digital Analysis Alliance of Canada. ICR will assist capability constructing initiatives to reinforce knowledge literacy inside its group, in addition to assist the present and subsequent era of researchers to accumulate the experience and skillsets wanted to combine knowledge science and superior analytics into their analysis and deploy them into the scientific realm.

Alignment to CIHR’s 2021-2031 Strategic Plan

Aligned with CIHR’s precedence to strengthen Canada’s well being analysis capability,^{Footnote 11} ICR is dedicated to establishing coaching and profession helps that allow the present and subsequent era of researchers to collaborate and lead in leveraging knowledge science and superior analytics for most cancers analysis. ICR additionally shares CIHR’s dedication to selling the accessibility of analysis knowledge by means of open science and serving to its various analysis group make simpler use of current most cancers knowledge and experience by means of nationwide and worldwide collaborations and partnerships. As we interact various stakeholders and companions throughout Canada’s strong most cancers analysis knowledge ecosystem, ICR will promote First Nations, Inuit, and Métis knowledge governance and self-determination in well being analysis and foster the sharing of experience and sources, together with knowledge analyses addressing intersectionality, to enhance the well being of individuals in Canada and past.

ICR’s full alignment with CIHR’s strategic priorities may be present in Appendix A.

Objectives

1. Foster open science by supporting and increasing nationwide efforts to make sure the suitable administration and sharing of information.
2. Improve knowledge literacy and useful resource utilization throughout the most cancers analysis group.
3. Promote the accountable use of superior analytics throughout your complete spectrum of most cancers analysis.

Actions

1. Have interaction and collaborate with key stakeholders and companions to ascertain a complete understanding of information belongings throughout Canada by means of the creation of a pan-Canadian most cancers knowledge asset map.
2. Convey the most cancers analysis perspective and key stakeholders and companions to nationwide efforts to foster open science and knowledge sharing, in addition to to advance the position of synthetic intelligence in well being care in Canada.
3. Help researchers all in favour of integrating inclusive, intersectional, and modern skillsets, applied sciences, and strategies in knowledge science and superior analytics into their analysis.

Measures of Success

1 – 3 Years

• Development within the consciousness of accessible knowledge belongings throughout Canada with extra researchers leveraging current sources and infrastructure.
• Elevated variety of research reporting on shared well being analysis knowledge.
• Enhanced consciousness and implementation of finest practices for knowledge administration and sharing in most cancers analysis.

5 Years

• Development within the integration of skillsets, applied sciences, and strategies using knowledge science and superior analytics in most cancers analysis and their utility in well being care.
• Progress in direction of growth of a nationwide analysis knowledge infrastructure by means of collaborations inside and past CIHR to harmonize knowledge requirements and execute on a united Pan-Canadian Most cancers Analysis Information Technique.
• Demonstrated worth and influence of accountable superior analytics in most cancers analysis and care supply.

Influence

A greater coordinated and simpler method to streamlining the gathering, integration, and use of most cancers knowledge throughout Canada to construct a cohesive most cancers analysis knowledge ecosystem that features entry to disaggregated knowledge and might present equity-driven insights to optimize most cancers care and inform insurance policies that can enhance the well being of the total range of individuals dwelling in Canada.

A precedence grounded in most cancers knowledge will catalyze discovery and innovation within the Canadian most cancers analysis panorama. This precedence reinforces the significance of our collective motion to uncover how superior analytics and most cancers knowledge come collectively to speed up most cancers analysis, remodeling the most cancers expertise for everybody in Canada.

Cross-Reducing Rules

Our cross-cutting ideas form all features of ICR’s actions and engagement with our most cancers analysis and affected person communities, and can drive every of our Analysis Precedence Areas.

Collaborations & Partnerships

Figuring out, constructing, and strengthening collaborations and partnerships lie on the coronary heart of all our actions. From researchers, individuals with lived and dwelling expertise, authorities and group organizations, trade, funding businesses, to different CIHR Institutes, ICR is dedicated to meaningfully consulting and interesting its various communities to collectively discover alternatives for collaboration and innovation, improve and mobilize information and sources, construct capability, and promote evidence-informed practices and insurance policies that equitably and inclusively handle the wants of all individuals impacted by most cancers.

Capability Constructing

Working in an ever-evolving most cancers panorama, equipping the present and subsequent era of researchers with the talents and experience to steer most cancers analysis within the twenty first century is a precedence for ICR. We’re dedicated to strengthening Canada’s most cancers analysis capability by enhancing coaching and delivering profession assist to researchers at each stage of their careers, with a deal with under-represented teams, trainees, and early profession researchers.

Data Mobilization & Implementation

ICR is dedicated to pairing analysis with energetic information mobilization to shut the hole between discovery and influence. We’ll try to facilitate the mobilization of recent information into Canada’s well being methods in order that well timed and correct data reaches various communities, allowing people to make knowledgeable selections about their well being, and aiding coverage makers and well being care suppliers to translate research-generated insights into new insurance policies and equitable and inclusive scientific care supply.

Affected person & Group Engagement

ICR prioritizes and values collaboration with our affected person companions and broader communities. Actively partaking sufferers and group stakeholders and companions early and sometimes within the analysis course of will make sure that our actions are knowledgeable, related, impactful, and finally centered on assembly the wants and preferences of these impacted by most cancers.

Fairness, Variety & Inclusion

ICR underscores that the ideas of fairness, range, and inclusion are central to all of our actions and targets, starting from figuring out and designing analysis initiatives and groups, to peer-review panels, information mobilization, partnerships, and group engagement. We’ll foster a analysis tradition that’s inclusive and equitable and capitalizes on the total breadth of Canada’s various scientific expertise and communities.

Indigenous Peoples’ Well being & Properly-Being & Indigenous Rights

Guided by a dedication to reconciliation and allyship, ICR will respectfully interact Indigenous communities as energetic companions for collaboration in distinction-based analysis actions, making certain our method and actions are inclusive and respectful of Indigenous cultures, beliefs, values, and information methods.

Acknowledgements

ICR wish to lengthen our honest gratitude to members of the most cancers analysis group who shared their experience and insights with us throughout our strategic precedence setting course of, and can proceed to assist the supply of our actions. These members embrace researchers, well being professionals, individuals with lived and dwelling expertise, caregivers, nationwide and worldwide companions, trainees, Indigenous communities, trade, governmental coverage makers, members of the general public, in addition to our CIHR Built-in Institute Workforce and different CIHR Institutes and workers. We additionally give particular because of the ICR Institute Advisory Board for his or her ongoing assist and steering. Your entire collective knowledge and contributions have been essential in defining and shaping our strategic targets and analysis priorities for 2024-2029.

Members of the Engagement Course of

• Nova Scotia Engagement Workshop
  
  November 2, 2022
• British Columbia Engagement Workshop
  
  November 7, 2022
• Quebec Engagement Workshop
  
  November 14-15, 2022
• Ottawa Engagement Workshop
  
  December 13, 2022
• Ontario Engagement Workshops
  
  January 11 & March 9, 2023
• Alberta Engagement Workshop
  
  February 8-9, 2023
• Manitoba Engagement Workshop
  
  February 28-March 1, 2023
• Saskatchewan Engagement Workshop
  
  March 29, 2023
• Indigenous Group Engagements
  
  January 9, February 3 & March 10, 2023
• Affected person Companions Focus Teams
  
  February 3 & 10, 2023
• Nationwide Companions Engagements
  
  October 2, 2022, April 26 & July 25, 2023
• Worldwide Companions Engagements
  
  March 2 & April 15-17, 2023
• Deliberative Dialogue Workshop (DDW)
  
  June 20-21, 2023
• Group Engagement Survey
  
  July 2023

The complete listing of DDW contributors may be present in Appendix B.

Institute Advisory Board

• Christine Williams (Chair)
  
  Ontario Institute for Most cancers Analysis
• Nathalie Baudais
  
  Metropolis of Saskatoon
• Parveen Bhatti
  
  BC Most cancers
• Juliet Daniel
  
  McMaster College
• Bertrand Jean-Claude
  
  McGill College Well being Centre
• Trevor Pugh
  
  Ontario Institute for Most cancers Analysis
• Robin Urquhart
  
  Beatrice Hunter Most cancers Analysis Institute
• Hanne Ostergaard (Vice-Chair)
  
  College of Alberta
• Jason Berman
  
  CHEO Analysis Institute
• Kimberley Brewer
  
  IWK Well being Science Centre
• Martin Hirst
  
  BC Most cancers Genome Sciences Centre
• Erika Penz
  
  College of Saskatchewan
• Lee-Hwa Tai
  
  College of Sherbrooke

Institute Employees

• Fei-Fei Liu
  
  Scientific Director
• Kelly Hancock
  
  Enterprise Officer
• Shirley Chung
  
  Analysis Affiliate
• Emma Ito
  
  Assistant Director
• Brooke Low
  
  Communications Specialist and Undertaking Coordinator
• Naseem Shaikh
  
  Occasion and Undertaking Coordinator

Particular Thanks

• Canadian Most cancers Society
• Most cancers Analysis Society
• CIHR Built-in Institute Workforce
• Fuselight Artistic
• Santis Well being
• Taylor MacLean
• Terry Fox Analysis Institute

 

Contact Us

CIHR Institute of Most cancers Analysis

College Well being Community

700 College Avenue, 4th Ground, Room 4-095

Toronto, ON M5G 1Z5

E-mail: cihr.icr@uhn.ca

Telephone: 1-888-603-4178

X: @CIHR_ICR

Appendix A: Alignment with the CIHR Strategic Plan 2021-2031

CIHR Strategic Precedence A: Advance Analysis Excellence in All Its Variety

ICR Strategic Priorities	Technique 1: Champion a extra inclusive idea of analysis excellence	Technique 2: Help stronger analysis groups	Technique 3: Promote open science	Technique 4: Improve nationwide & worldwide collaboration
Precedence 1: Refocus on Most cancers Prevention, Early Detection & Danger Discount	Applicable.	Applicable.	Applicable.	Applicable.
Precedence 2: Mitigate Therapy Toxicities to Enhance Most cancers Survivorship	Applicable.	Applicable.	Applicable.	Applicable.
Precedence 3: Remodel Most cancers Analysis By Information Technique & Superior Analytics	Applicable.	Applicable.	Applicable.	Applicable.
(A)pplicable.

CIHR Strategic Precedence B: Strengthen Canadian Well being Analysis Capability

ICR Strategic Priorities	Technique 1: Strengthen investigator-initiated analysis	Technique 2: Promote fairness, range & inclusion	Technique 3: Improve coaching & profession assist	Technique 4: Improve CIHR’s speedy response capability
Precedence 1: Refocus on Most cancers Prevention, Early Detection & Danger Discount	Applicable.	Applicable.	Applicable.
Precedence 2: Mitigate Therapy Toxicities to Enhance Most cancers Survivorship	Applicable.	Applicable.	Applicable.
Precedence 3: Remodel Most cancers Analysis By Information Technique & Superior Analytics	Applicable.	Applicable.	Applicable.	Applicable.
(A)pplicable.

CIHR Strategic Precedence C: Speed up the Self-Willpower of Indigenous Peoples in Well being Analysis

ICR Strategic Priorities	Technique 1: Advance the well being and well-being of First Nations, Inuit & Métis Peoples	Technique 2: Speed up implementation of the CIHR Motion Plan: Constructing a More healthy Future for First Nations, Inuit & Métis Peoples	Technique 3: Take away boundaries to Indigenous-led analysis
Precedence 1: Refocus on Most cancers Prevention, Early Detection & Danger Discount	Applicable.	Applicable.	Applicable.
Precedence 2: Mitigate Therapy Toxicities to Enhance Most cancers Survivorship	Applicable.	Applicable.	Applicable.
Precedence 3: Remodel Most cancers Analysis By Information Technique & Superior Analytics	Applicable.	Applicable.	Applicable.
(A)pplicable.

CIHR Strategic Precedence D: Pursue Well being Fairness by means of Analysis

ICR Strategic Priorities	Technique 1: Scale back well being inequities by means of analysis	Technique 2: Champion analysis on the determinants of well being	Technique 3: Drive progress on world well being analysis
Precedence 1: Refocus on Most cancers Prevention, Early Detection & Danger Discount	Applicable.	Applicable.	Applicable.
Precedence 2: Mitigate Therapy Toxicities to Enhance Most cancers Survivorship	Applicable.	Applicable.	Applicable.
Precedence 3: Remodel Most cancers Analysis By Information Technique & Superior Analytics	Applicable.	Applicable.	Applicable.
(A)pplicable.

CIHR Strategic Precedence E: Combine Proof in Well being Selections

ICR Strategic Priorities	Technique 1: Advance the science of information mobilization	Technique 2: Maximize outcomes for Canadians	Technique 3: Strengthen Canada’s well being methods by means of innovation
Precedence 1: Refocus on Most cancers Prevention, Early Detection & Danger Discount	Applicable.	Applicable.	Applicable.
Precedence 2: Mitigate Therapy Toxicities to Enhance Most cancers Survivorship	Applicable.	Applicable.	Applicable.
Precedence 3: Remodel Most cancers Analysis By Information Technique & Superior Analytics	Applicable.	Applicable.	Applicable.
(A)pplicable.

Appendix B: Deliberative Dialogue Workshop Members

• Deborah Anderson
  Saskatchewan Most cancers Company
• Michelle Audoin
  Affected person Associate
• Rebecca Auer
  Ottawa Hospital Analysis Institute
• Vicky auf der Mauer
  Affected person Associate
• Philip Awadalla
  Ontario Institute for Most cancers Analysis
• Versha Banerji
  College of Manitoba
• Jill Barnholtz-Sloan
  Nationwide Most cancers Institute
• Christian Baron
  Canadian Institutes of Well being Analysis
• Gerald Batist
  McGill College
• Nathalie Baudais
  Affected person Associate
• John Bell
  Ottawa Hospital Analysis Institute
• Jason Berman
  CHEO Analysis Institute; ICR Institute Advisory Board
• Parveen Bhatti
  BC Most cancers Analysis Institute; ICR Institute Advisory Board
• Jeanette Boudreau
  Dalhousie College
• Judy Bray
  Canadian Most cancers Society
• Darren Brenner
  College of Calgary
• Kimberly Brewer
  Dalhousie College; ICR Institute Advisory Board
• Philip Citadel
  Nationwide Most cancers Institute
• Dean Chamberlain
  Saskatchewan Most cancers Company
• An-Wen Chan
  College of Toronto
• Jennifer Chan
  College of Calgary
• Stephen Chanock
  Nationwide Most cancers Institute
• Victor Chong
  Merck
• Nabilah Chowdhury
  Canadian Institute for Superior Analysis
• Sherri Christian
  Memorial College of Newfoundland
• Amy Clark
  Affected person Associate
• Kelly Cobey
  College of Ottawa Coronary heart Institute
• Jennifer Sofa
  Nationwide Most cancers Institute
• Kerry Courneya
  College of Alberta
• Ekaterina Dadachova
  College of Saskatchewan
• Juliet Daniel
  McMaster College; ICR Institute Advisory Board
• Tanja Davidsen
  Nationwide Most cancers Institute
• Paul Demers
  Ontario Well being
• Trevor Dummer
  College of British Columbia
• Alison Dungey
  AstraZeneca
• Craig Earle
  Canadian Partnership Towards Most cancers
• Stuart Edmonds
  Canadian Most cancers Society
• Jill Edmondson
  Affected person Associate
• Jodi Edwards
  College of Ottawa Coronary heart Institute
• Thomas Flannery
  Affected person Associate
• Eduardo Franco
  McGill College
• Andrew Freywald
  College of Saskatchewan
• Christine Friedenreich
  Alberta Well being Providers
• Katherine Frohlich
  College of Montreal; Canadian Institutes of Well being Analysis
• Chantelle Garritty
  Public Well being Company of Canada
• Ron Geyer
  College of Saskatchewan
• Spencer Gibson
  College of Alberta
• Satish Gopal
  Nationwide Most cancers Institute
• Robert Grant
  Princess Margaret Most cancers Centre
• Jennifer Gunning
  Canadian Institutes of Well being Analysis
• Benjamin Haibe-Kains
  Princess Margaret Most cancers Centre
• Sean Hanlon
  Nationwide Most cancers Institute
• Shane Harding
  Princess Margaret Most cancers Centre
• Denise Hemmings
  College of Alberta
• Jason Hicks
  The Atlantic Partnership for Tomorrow’s Well being Examine
• Bertrand Jean-Claude
  McGill College; ICR Institute Advisory Board
• Jennifer Jones
  Princess Margaret Most cancers Centre
• Angela Kaida
  Canadian Institutes of Well being Analysis
• Sachin Katyal
  College of Manitoba
• John Kildea
  McGill College
• David Kirsch
  Princess Margaret Most cancers Centre
• Sonny Kohli
  Roche Canada
• Jennifer Kwan
  College of Toronto
• Cheng-Han Lee
  College of Alberta
• Stephen Lewis
  Atlantic Most cancers Analysis Institute
• Peter Liu
  College of Ottawa Coronary heart Institute
• Benjamin Lok
  Princess Margaret Most cancers Centre
• Jean-Yves Masson
  Laval College
• John McLaughlin
  College of Toronto
• Rachel Murphy
  College of British Columbia
• Paul Nathan
  SickKids
• Dajan O’Donnell
  Most cancers Analysis Society
• Hanne Ostergaard
  College of Alberta; ICR Institute Advisory Board
• Anbalakan Paramasivam
  Most cancers Analysis UK
• Morag Park
  McGill College
• Stuart Peacock
  Simon Fraser College & BC Most cancers
• Erika Penz
  College of Saskatchewan; ICR Institute Advisory Board
• Lynne-Marie Postovit
  Queen’s College
• Carla Prado
  College of Alberta
• Angus Pratt
  Affected person Associate
• Laszlo Radvanyi
  Ontario Institute for Most cancers Analysis
• Srinivas Raman
  Princess Margaret Most cancers Centre
• Lana Ray
  Lakehead College
• Zeev Rosberger
  McGill College
• George Ross
  Digital Analysis Alliance of Canada
• Bertrand Routy
  College of Montreal Well being Centre
• Aaron Schimmer
  Princess Margaret Most cancers Centre
• Jan Seuntjens
  Princess Margaret Most cancers Centre
• Lillian Siu
  Princess Margaret Most cancers Centre
• Victoria Smith
  Digital Analysis Alliance of Canada
• Michael Robust
  Canadian Institutes of Well being Analysis
• Ellen Sweeney
  Dalhousie College
• Lee-Hwa Tai
  College of Sherbrooke; ICR Institute Advisory Board
• Sara Urowitz
  Canadian Partnership Towards Most cancers
• Robin Urquhart
  Dalhousie College; ICR Institute Advisory Board
• Christiane Vaillancourt
  Canadian Institutes of Well being Analysis
• Jennifer Vena
  Alberta Well being Providers
• Daryl Waggott
  Genome Canada
• Peter Watson
  BC Most cancers
• Michael Weinfeld
  College of Alberta
• Christine Williams
  Ontario Institute for Most cancers Analysis; ICR Institute Advisory Board
• Philip Wong
  Princess Margaret Most cancers Centre
• Jim Woodgett
  Terry Fox Analysis Institute
• Bradly Wouters
  College Well being Community
• Lin Yang
  Alberta Well being Providers
• Kenneth Yip
  College of Toronto

Picture Credit

Canadian Most cancers Society

Date modified:

2024-02-05